Cancer Flashcards
1
Q
Role of MSH2 and MLH1
A
DNA repair genes for mismatch repair.
2
Q
Role of BRCA 1
A
interacts with DNA repair protein complex. a mutation causes defective repair of double stranded breaks.
3
Q
What is the result of a BRCA 1 mutation
A
Truncated protein products and loss of function in tumor suppresion.
4
Q
RB1 mutation
A
binds to E2F transcription factor and causes cell cycle brake. With mutation there is no stop of the cell cycle and cells continually grow.
5
Q
P53
A
induces Cell cycle arrest or apoptosis. causes Li-Farumen syndrom with mutation due to a somatic mutation.
6
Q
What is the most common altered cancer- causing gene?
A
P53
