Pharmacodynamics and Drug Receptors

Question 1

Name three major mechanisms of transduction and amplification.

Answer 1

1. Ligand-gated ion channel
2. G-protein Coupled channels
3. Kinase-ligand receptors or Homone (nuclear) receptor

Question 2

Name three types of receptor molecules:

Answer 2

1. Protein: Most specific
2. Nucleic Acid
3. Membrane lipids

Question 3

What are the three consequences of Drug Receptor Theory?

Answer 3

1. Receptors are responsible for selectivity of drug action.
2. Receptors mediate the actions of pharmacologic agonists and antagonists
3. Receptor theory allows determination of quantitative relation between dose or concentration fo drug and it pharmacologic effect via dose response curve.

Question 4

What is the X and Y axis on the Dose-Response Curve?

Answer 4

Y axis- Percent of the maximum response possible

X axis- Dose [D]

Question 5

Define potency.

Answer 5

The concentration (EC50) required to produce 50% of the drug’s individual maximal effect. Depends on Kd