Pharmacodynamics

Question 1

When give alone a drug that express membrane receptors, does not alter intracellular cascades, What type of drug was administered?

Answer 1

Competitive antagonist

Question 2

Based on data, how would you describe thiazide A in comparison to thiazide B?

Placebo : increase 0.5
5mg thiazide A: decrease 4
500mg thiazide B: decrease 4

Answer 2

thiazide is more potent

Question 3

The figure below shows the response associated with a 10mg/kg
dose of drug A (represents the ED50 for drug A). If you repeated this
dose of drug A in the presence of a fixed dose of the relevant
competitive receptor antagonist, where would you expect the “x” to
be placed on the graph above in comparison to its current position?

Answer 3

directly below

Question 4

If a log dose response curve for a full agonist with a fixed dose of a
partial agonist for the same receptor were administered at the same
time, how would the log dose response curve compare with the
curve produced in the presence of the full agonist alone?

Answer 4

dose response would be a parellel shift to the right

Question 5

What is therapeutic index and the lower/high the value the safer?

Answer 5

TD50/ED50, higher

Question 6

Receptor occupancy is primarily determined by which pharmacodynamic property of the drug that is interacting with the receptor?

Answer 6

Affinity