Pharmacodynamics Flashcards
What is the many type of drug target in the body
Enzymes then GPCRs
What unit is used to measure drug concentration
Molarity
What must a ligand posses in order to bind to a receptor
Affinity
What is intrinsic efficacy
The ability to activate a receptor by causing a conformational change
What type of ligand results in an intrinsic efficacy
Agonist
What is efficacy
The ability of a ligand to cause a response
Why don’t antagonists cause a response
They possess no intrinsic efficacy
How is drug receptor binding measured
Using radio ligands
What is Kd
The drug concentration at 50% bound receptors
What is Kd a measure of
Affinity
Why is it good for drugs to have a high affinity for receptors
Can use smaller tablets
What graph shape do log[drug] vs bound receptors show
Sigmoidal
What is EC 50
Effective concentration giving 50% response
Define concentration
Known concentration of drugs at a site of action
Define dose
Concentration at site of action unknown