Pharmacodynamics Flashcards
structure of neuron
dendrites, cell body, axon
what ions involved in action potention
Na and K
IN AP - does Na diffuse inwards or outwards
inwards
IN AP - does K diffuse inwards or outwards
outwards
TRUE OR FALSE.. In AP, stimulation of neuron changes membrane permeability to ions
true
term used in AP when Na floods into cell through sodium channels setting up nerve implulse
depolarisation
IN AP, once Na floods cell, what ion flows out of cell, and membrane charge returns to normal (known as repolarisation)
potassium (K)
IN AP, what ‘pump’ restores correct ion balance?
sodium-potassium pump
name events at the synapse..
- impulse causing depolarisation at synaptic knobs
- vesicles release NT –.> synaptic cleft
- NT diffuse across synaptic cleft
- depolarisation of postsynaptic membrane
- conductioon of impulse to next neuron or effector organ activated.
Autonomic system made up of sympathetic and parasympathetic nervous system (SNS and PNS).. true or false
true
SNS = maintains essential body functions, or responds to stress?
stress
PNS - maintains essential body functions
SNS principal effects with regards to bronchi, vessels, heart rate, eyes
smooth muscle relaxtion = bronchodilation, vasodilation, increased HR, dilated pupils
true or false ..PNS decreases blood flow to digestive organs, decreased perstalsis, decreased secretion of urine
false… increases them
modes of drug action (3 groups)
receptors, enzymes, membrane transport sysytems
antagonist, agonist, partial agonist are involved with what mode of drug action?
receptors
antagonist, agonist, partial agonist are involved with what mode of drug action?
receptors
3 main groups of receptors..
adrenergic, cholinergic, histamine
Adrenergic contain what receptors, and where is their main location?
A1-Smooth muscle, blood vessels
A2-Smooth muscle, blood vessels (CNS)
B1 - HEART
B2 - Smooth muscle inc cardiac n resp
example of B2 agonist ..
salbutamol
name given to a drug (exogenous ligand) that interact with receptor and activates it
agonist
name given to a drug (exogenous ligand) that interacts with receptor and blocks natural messenger (competitive)
antagonist
partial antagonists have properties of both but are less potent as..
agonists
term for chemical messenger
ligand
name given to locally chemicals that bind to receptors on adjacent or nearby cell receptors - producing effect (e.g histamine)
mediators
