Pharmacodynamics

Question 1

What changes on a dose response curve when: a full agonist is given followed by an antagonist?

Answer 1

The curve shifts downward, no longer reaches Emax

Question 2

What changes on a dose response curve when: a full agonist is given followed by an antagonist and then another dose of a full agonist with competitive binding?

Answer 2

The curve shifts to the right, needs a higher dose to achieve Emax

Question 3

What changes on a dose response curve when: a full agonist is given followed by an antagonist and then another dose of a full agonist with non-competitive binding?

Answer 3

The curve shifts to the right and downward, needs higher dose but cannot achieve Emax

Question 4

What are the bonds from weakest to strongest?

Answer 4

Van de Wall, hydrogen, ionic, covalent

Question 5

What does Substance P affect?

Answer 5

Pain, temperature, and nausea

Question 6

Which receptor does Substance P interact with that causes nausea and vomiting?

Answer 6

Neurokinin 1 (NK1)