Pharmacodynamics

Question 1

adverse drug event

Answer 1

injury that occurs during treatment not necessarily caused by the drug itself

Question 2

adverse drug reaction

Answer 2

“response to a drug which is noxious and unintended and which occurs at doses normally used in man
Usually mimic disease or syndrome

Question 3

types of ADR

Answer 3

Exaggerated response Desired pharmacological effect at alternative/additional site (GTN –headache)
Additional/secondary pharmacological effect (QT length) Triggering an immunological response (anaphylaxis)

Question 4

type A ADR

Answer 4

augmented, 
dose dependent, 
frequent, 
predictable, 
drug overdose, 
explained by pharmacologic drug effect

Question 5

type B ADR

Answer 5

bizarre, 
dose independent, 
rare, 
unpredictable, 
not explained by pharmacologic drug effect

Question 6

pharmacogenetics

Answer 6

small number of genes involving drug metabolism

Question 7

pharmacogenomics

Answer 7

complex multigene patterns within the genome. to predict they will respond to drugs

Question 8

commitment to genomic medicine

Answer 8

genomes project, genomics education, genomic medicine service, pharmacogenetics agenda, precision medicine