Pharmacodynamics

Question 1

Therapeutic index

Answer 1

LD50/ED50

Question 2

therapeutic window

Answer 2

TD50/ED50

Question 3

If you take agnostic chronically, how does tolerance occur?

Answer 3

tolerance caused by receptor down regulation. Fewer receptors, so more agonists needs to be given to stimulate limited receptors.

Question 4

If you take antagonists chronically, how does tolerance occur?

Answer 4

tolerance caused by up regulation. So more receptors, more antagonists needs to be given to block the increased receptors

Question 5

Receptor bonds from weakest to strongest

Answer 5

van der Waals, hydrophobic, hydrogen, ion, covalent

Question 6

define inotropic receptor

Answer 6

one type of nervous system receptor. also known as ligand gated ion channel receptor. e.g. Gaba receptor

Question 7

define metabotropic receptor

Answer 7

indirectly linked with channels, like G protein coupled receptors

Question 8

albumin bind to what drug

Answer 8

acidic drugs

Question 9

alpha 1 acid glycoprotein and beta globulin binds to what drug

Answer 9

basic drugs

Question 10

graded dose response

Answer 10

describes response compared to dose of drug. E.g. how much does a vessel constricts with increased norepinephrine dose?

Question 11

quantal dose response

Answer 11

It describes the % of a certain population responds to a certain dose of drug. E.g. % of people fall asleep given 5mg/kg propofol bolus. LD50 and ED50 are from quantal dose response.