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Summer Semester Final > Pharmaceutics 3 > Flashcards

Pharmaceutics 3 Flashcards

1
Q

What’s types of coating equipments ?

A

The Standard coating pan
The perforated coating pan
The fluidized bed coated

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2
Q

Definition of coating tablets

A

The application of coating composition to a moving bed of tablets with the concurrent use heated air to facilitate evaporation of the solvent

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3
Q

What’s types of coating use to protect from gastric environment ?

A

Enteric coating acid resistance

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4
Q

Mention standard coating pan modifications

A

The Pellegrini pan
The immersion sword
The immersion tube

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5
Q

What’s the worst shape for coating tablets ?

A

Square flat- faced tablets

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6
Q

True or false Q: tablets properties tablets must be rough to coated ?

A

False, should have smooth surface

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7
Q

In tablets properties : what’s the best shape to coated tablets ?

A

Spherical shape

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8
Q

In tablets properties : what’s the best shape to coated tablets ?

A

Spherical shape

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9
Q

Why’s the sphere is best shape to coated tablets ?

A

Because 1) it’s allows tablets to rolls freely in the coating pan
And 2) have minimal contact

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10
Q

Why is square flat-faced is the worst shape ?

A

Because in coating materials would collect btw the surface to glue them together
راح يتجمع مواد الطلاء بين الأسطح وتلتصق ببعض

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11
Q

What’s diameter in standard coating pan ?

A

8 to 60 inches and rotated horizontal axis

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12
Q

Types of application coating solution ?

A

Ladling and spray

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13
Q

True or false
Ladling is a manual ?

A

True

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14
Q

True or false
Spraying application is automatic?

A

True

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15
Q

Advantage spraying over ladling ?

A

1) faster
2) more distributions

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16
Q

Characteristics of the standard coating pan ?

A

1) inlet air supply and exhaust are separated
2) not immersed
3) open

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17
Q

Character of immersion swords coating

A

1) closed
2) inlet and exhaust are one unit “ not separated “
3) perforated
4) immersed

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18
Q

Characters of immersion tube ?

A

1) inlet and exhaust are separated
2) open
3) immersed
4) coating solution and heated are fused
5) rapid processing times

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19
Q

Types of perforated coating pan system ?

A

1) Accela-Cota
2) Hi-coated

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20
Q

Accela-Cola are totally perforated ? True or false

A

True

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21
Q

Hi-coater are totally perforated? True or false

A

False
Partially perforated

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22
Q

What’s the highest efficiency drying coating system?

A

Fluidized bed system

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23
Q

Air capacity depends on

A

1) quantity of air flowing through the tablet bed
2) temperature of the air
3) the quantity of water the inlet air contains

Notes : increase temperatures will increase capacity to evaporate water or solvent

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24
Q

Coating application depends on

A

1) spray rate
2) composition of the coating solution
3) droplets size produced ( pressure ,flow rate , viscosity)
4) tablets surface area
5) pan speed

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25
Q

Increase of pressure will increase droplets size ? True or false

A

False
Increase of pressure will decrease droplets size

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26
Q

Decrease of viscosity will decrease droplets size ? True or false

A

True

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27
Q

Increase flow rate will decrease droplets size ? True or false

A

True

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28
Q

In spraying process depends on skill of the coating operator ? True or false

A

False
In ladling process depend on skill of the coating operator

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29
Q

Steps coating sugar in order ?

A

1) seal coating
2) subcoating
3) syrup
4) polishing

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30
Q

Seal coating must be hydrophilic ? True or false

A

False
Hydrophobic not hydrophilic

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31
Q

In spraying do you need seal coating? Yes or no

A

No
Just in ladling method

32
Q

Why shellac coating length times to disintegration and dissolution times ?

A

Because of the polymerization of the shellac

33
Q

Source of shellac ?

A

Is resin secreted by female lac bug on tree forest in India and Thailand

34
Q

Source of Zein ?

A

Alcohol soluble protein derivation from corn

35
Q

Role of subcoating ?

A

To build up the tablet size and increase Thickness

36
Q

Steps in subcoating ?

A

2 steps
1) sticky binder solution
2) subcoating powder

37
Q

In spray method you can mix both sticky binder and insoluble powder ? True or false

38
Q

How many steps in syrup ? Mention steps

A

3 steps
1) glossy syrup
2) syrup containing color
3) clear coat in end

39
Q

Machines using in polishing step ? Mention

A

1) clean standard coating
2) canvas lined polishing

40
Q

film coating material must be stable in heat and moisture and light only ? True or false

A

False
Must be stable in Moisture and air and light and heat

Remember 4 conditions

41
Q

Using enteric coated for

A

To be acid resistance and release in intestine

42
Q

Non enteric coated role ?

A

To protect the tablet from light and moisture and oxidation and heat

43
Q

Mention enteric coated examples

A

1) hydroxypropyl methylcellulose
2) methyl hydroxyethylcellulose
3) ethylcellulose
4) hydroxypropylcellulose
5) povidone
6) sodium carboxymethylcellulose
7) polyethylene glycol

44
Q

Mention non enteric coated examples

A

1) hydroxypropyl methylcellulose
2) methyl hydroxyethylcellulose
3) ethylcellulose
4) hydroxypropylcellulose
5) povidone
6) sodium carboxymethylcellulose
7) polyethylene glycol

45
Q

HPMC high flexibility when use it alone ? True or false

A

False
High flexibility when using plasticiser

46
Q

HMPC have different viscosity grades ? True or false

47
Q

HMPC no interference with disintegration ? True or false

A

True and bioavailability

48
Q

HMPC insoluble in GIF but soluble in organic and aqueous solvent ? True or false

A

False
Soluble in GIF and organic and aqueous solvents

49
Q

High flexibility mean no filling and no bridges? True or false

50
Q

How to improve flexibility ?

A

Add plasticizer

51
Q

What the percentage use mix btw HMPC and ethylcellulose to get fast sustained release ?

A

75% HMPC + 25% ETHYLcellulose

52
Q

What the percentage use mix btw HPMC and ethylcellulose to get slow sustained release ?

A

50% HPMC + 50% ethylcellulose

53
Q

Mix ethylcellulose with coating have water soluble to improve disintegration? True or false

54
Q

ethylcellulose alone have high disintegration rate ? True or false

A

False
No disintegration rate

55
Q

Ethylcellulose unstable in most environments conditions? True or false

A

False
Stable

56
Q

Hydroxypropylcellulose can use it as subcoating in sugar coated ? True or false

57
Q

Hydroxypropylcellulose can use it as subcoating in sugar coated ? True or false

58
Q

Disadvantages of hydroxypropylcellulose is an extremely tacky ? True or false

59
Q

How solve tracky in povidone coated ?

A

Use 1) plasticizer 2) suspended powder 3) other polymers

60
Q

Use povidone to improve dispersion of colorant ? True or false

61
Q

Film coating material ideal must be ease to printing on low speed ? True or false

A

False
High speed not low speed that take time

62
Q

Sodium carboxymethylcellulose insoluble in few organic solvents ? True or false

A

False
Most not few

63
Q

Polyethylene glycol coating is soft film? True or false

A

Falseee
Hard film

64
Q

Polyethylene glycol is resistant to elevated temp ? True or false

A

False
Sensitive to elevated temp

65
Q

Mention reasons to choose enteric coating ?

A
  • to protect acid labile drugs
  • to prevent gastric distress or nausea due to irritation from drugs
  • to deliver drug intended for local action in the intestine “ local action “
  • to deliver drug that are optimally absorbed in the small intestine to their primary absorption site on their most concentration form
  • to provide a delayed release component for repeat action tablets
66
Q

Is design enteric coated for drugs have absorption window ? True or false

A

True
Maximum absorption in intestine

67
Q

We can use enteric coated for immediate releases ? Yes or no

A

No
For delay and repeated action release

68
Q

Enteric must be permeable to intestine coated ? True or false

69
Q

No matter if enteric coated is changing stability I aging ? True or false

A

False
Must be stable on aging for changing

70
Q

Mention enteric film former?

A

1 cellulose acetate phthalate
2 acrylate polymers
3 hydroxypropyl methylcellulose phthalate
4 polyvinyl acetate phthalate

71
Q

Cellulose acetate phthalate dissolves only below pH 6 . True or false

A

False
Only above pH 6

72
Q

Mention disadvantages of cellulose acetate phthalate

A

Hygroscopic
Permeable to moisture
Susceptible to hydrolytic
Brittle

73
Q

Phthalic and acetic acid is stable in aqueous media . True or false

A

False
Unstable

74
Q

How can you solve hygroscopic in CAP ( Cellulose acetate phthalate)

A

Combined with hydrophobic film forming materials to achieve a better enteric film

75
Q

Acetylate polymers is a copolymers. True or false

76
Q

Anionic Eudragit S soluble at pH 8?. True or false

77
Q

Choose of plasticizer depend on :

A

Viscosity
Tackiness
Solubility
Taste
Compatibility
Stability of the film and the product

Summer Semester Final (3 decks)

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