Hard Gelatin Capsule

Question 1

Hard gelatin capsule have a limited size and shapes ? False or true

Answer 1

True

Question 2

Mention methods for hard gelatin capsule ?

Answer 2

Traditional friction
Mechanical interlock
Banding and liquid sealing possible

Question 3

Percentage of hard hard gelatin fill accuracy ?

Answer 3

2- 5%
Increase with modern automatic machines

Question 4

Using liquid formulation technology in hard gelatin capsule ? True or false

Answer 4

False
Solids

Question 5

Mention advantage of hard gelatin capsules ?

Answer 5

Odorless
Tasteless
Easily swallowed
Elegant
Portable
Rapid drug release is possible

Question 6

How many process steps for production hard gelatin capsule ? And mention it

Answer 6

2
Manufacturers of hard gelatin capsule shell
Manufacturers of pharmaceutical dosage forms

التصنيع على مرحلتين وهي الأولى تصنيع غلاف الكبسوله بروحه
بعدين ينتقل لمصنع ثاني للتعبئة

Question 7

How many types of hard gelatin shells there ?
And mention isoelectric point

Answer 7

2 types of
Type A - -> isoelectric point 7.0 - 9.0
Types B - -> isoelectric point 4.8 - 5.0

Question 8

Source of natural gelatin ?

Answer 8

1 bone gelatin
2 skin gelatin

Question 9

Characteristic of bone gelatin ?

Answer 9

Tough - firm - hazy - brittle

Question 10

Characteristics of skin gelatin ?

Answer 10

Flexible - clear

Question 11

Why using dyes and colorant agent in gelatin ?

Answer 11

For production identification
For improve patient compliance

Question 12

Why using opaquing agent ?

Answer 12

For protection against light
For conceals the contents

Question 13

Mention hard shell made from non gelatin ?

Answer 13

Starch hydrolysate
Hydroxypropyl methylcellulose (vegicaps )
Methylcellulose
Polyvinyl alcohol
Denatured gelatin

Question 14

Mention manufacturing of hard gelatin capsule shells in order ?

Answer 14

1 dipping
2 rotation
3 drying
4 stripping
5 trimming
6 joining

Question 15

Pans made from iron ? True or false

Answer 15

False
Stainless steel

Question 16

Cap is shorter and narrower diameter ? True or false

Answer 16

False
Shorter and wider diameter

Question 17

Body of capsule is longer and narrower diameter ? True or false

Answer 17

True

Question 18

Cap and body made from same solution have different colors ? True or false

Answer 18

False
Same color
Different solution have different color

Question 19

Thickness of capsule shell depends on?

Answer 19

1 viscosity of gelatin solution
2 speed and time of dipping

Question 20

If gelatin shells storage in condition have moisture below 10% will be brittle and weak ? True or false

Answer 20

False
Brittle and shrink

Question 21

If gelatin shell storage have moisture above 16% will be brittle and weak ? True or false

Answer 21

False
Soft and weak

Question 22

What’s the proper moister content to storage gelatin shells ?

Answer 22

Btw 12% - 15%

Question 23

Role of rotation step in manufacturing shells ?

Answer 23

1 helps to distribute gelatin over the pins uniformly
2 avoid the formulation of a bead at the capsule ends

Question 24

Drying step done by humiliation to remove water gradually and precisely ? True and false

Answer 24

False
dehumidification

Question 25

You can using combination btw bone and skin gelatin? True or false

Answer 25

True

Question 26

Amount of diluent depends on ?

Answer 26

1 size of capsule طرديا
2 volume of the drug عكسيًا
Volume of other additives used عكسيًا

Question 27

Mention examples of dulients ?

Answer 27

Starch
Lactose
Dicalcium phosphate