Pharmaceutical Technology

Question 1

What are the functions of a filler

Answer 1

To increase bulk of tablet
To create a tablet size practical for patient
To create tablet weight around 50mg

Question 2

What is the function of lactose, mannitol and sorbitol as excepients of the tablet

Answer 2

Filler

Question 3

What will binders affect in a tablet?

Answer 3

Hardness, compressibility, granule uniformity

Question 4

An example of binder

Answer 4

Polyvinyl alcohol

Question 5

How do glidants work

Answer 5

Improve powder flow
- Forms a thin film on particle surface > particles are further apart > lower cohesion force
- reduces electrostatic cohesive forces between powder particles

Question 6

What is the importance of granulation

Answer 6

Particle enlargement > improves flow
Optimal size : 200-250 micrometre
75-100micro meter : problem with flow due to cohesive forces, static electrical forces

Question 7

Glidant efficiency is assessed from angle of repose. What is the formula for glidant efficiency and angle of repose?

Answer 7

Glidant efficiency : rate of flow with Glidant / rate of flow without

Angle of repose: tan (a) = height of cone/radius (< 20 = good flow)