Drugs In GI Disease

Question 1

What are the symptoms of ulcerative colitis?

Answer 1

1. Severe diarrhoea
2. Blood loss
3. Loss of peristaltic action and rigid colonic tube
4. Toxic mega colon

Question 2

3 Mechanism of action of Mesalamine

Answer 2

Mesalamine derived from sulfasalazine
Reduces inflammatory response
1. Inhibit leukotriene and prostanoid
2. Scavenge free radicals
3. Decrease neutrophil chemotaxis

Question 3

Name 3 types of immunosuppressants

Answer 3

Azathioprine
Cyclosporin
Methotrexate

Question 4

What drug inhibits purine and DNA synthesis leading to reduced inflammatory cell proliferation

Answer 4

Methotrexate and azathioprine