PHARMA PEARLS Flashcards
1
Q
Refers to the amount of a drug that reaches the systemic circulation
A
BIOAVAILABILITY
2
Q
Used to determine the safety and efficacy of generic drugs
A
BIOEQUIVALENCE
3
Q
Measure the dose or concentration required to bring about 50% of the drug’s maximal effect
A
POTENCY
4
Q
Dose at which 50% of individuals exhibit the specified quantal effect
A
MEDIAN EFFECTIVE DOSE
5
Q
Dose at which 50% of the animals manifest a particular toxic effect
A
MEDIAN TOXIC DOSE
6
Q
Transfer of drug from site of administration to bloodstream
A
ABSORPTION
7
Q
Refers to the apparent volume into which the drug is able to distribute
A
VOLUME OF DISTRIBUTION
8
Q
Elimination of a drug at a constant rate (Irrespective of Concentration)
A
ZERO-ORDER KINETICS
9
Q
Elimination at a rate that is proportional to the serum concentration of the drug
A
FIRST-ORDER KINETICS
10
Q
Addition of a polar moiety (Sulfate, Acetate or Glucoronate)
A
PHASE II METABOLISM
11
Q
Use of CYP450 system oxidation, reduction or hydrolysis
A
PHASE I METABOLISM
12
Q
Describes the rate at which a specific drug is cleared from the system
A
CLEARANCE
13
Q
Refers to the amount of time required for the amount of drug in the body to decrease the half of its value after the administration of the drug has been stopped
A
HALF-LIFE
14
Q
Defined as the single amount of drug that is needed to achieve a desired plasma concentration quickly
A
LOADING DOSE
15
Q
Amount of drug that must be given over time in order to maintain desired plasma concentration
A
MAINTENANCE DOSE
16
Q
Used as a measure of drugs safety
A
THERAPEUTIC DOSE
17
Q
Formula for therapeutic index
A
TD50/ED50 (TD: Toxic Dose, ED: Effective Dose)
18
Q
Refers to the dosage range between the minimum effective therapeutic concentration or dose and minimum toxic concentration or dose
A
THERAPEUTIC WINDOW
19
Q
Substance that shifts the graded dose-response curve to the right
A
COMPETITIVE ANTAGONIST
20
Q
Substance that does not produce the same maximum effect and is exhibited by a decrease in Emax
A
IRREVERSIBLE ANTAGONIST
21
Q
An antagonist that interacts directly with the agonist and not at all or only incidentally with the receptor
A
CHEMICAL ANTAGONIST
22
Q
The action of the drug on the body
A
PharmacoDynaMics
23
Q
The action of the body on the drug
A
PharmacoKineTics
24
Q
Permeation that is governed by Fick’s Law
A
AQUEOUS DIFFUSION
25
Permeation that is saturable and inhibitable
CARRIER TRANSPORT
26
Adverse effect that is infrequently observed in most patients
IDIOSYNCRATIC
27
Responsiveness decreases as a consequence of continued drug administration
TOLERANCE
28
Responsiveness diminishes rapidly after drug administration
TACHYPHYLAXIS
29
Induction of developmental defects in the fetus
TERATOGENESIS
30
Induction of malignant characteristics in cells
CARCINO- GENESIS
31
Induction of changes in the genetic material of animals of any age
MUTAGENESIS
32
Cytochrome P450 Inducers
(ETHel Booba takes PHEN-phen and Refuses GReasy CARB Shakes): Ethanol, Barbiturates, Phenytoin, Rifampicin, Griseofulvin, Carbamazepine, St. John's Wort/ Smoking
33
Cytochrome P450 Inhibitors
(Inhibitors Stop Cyber Kids from Eating GRApefruit QV): Isoniazid, Sulfonamides, Cimetidine, Ketoconazole, Erythromycin, Grapefruit Juice, Ritonavir, Amiodarone, Quinidine, Valproic Acid
34
100% bioavailability
INTRAVENOUS
35
First Pass Effect
ORAL
36
Partial Avoidance of First Pass Effect
RECTAL
37
Application to skin for local effect
TOPICAL
38
Application to skin for systemic effect
TRANSDERMAL
39
Small number of normal volunteers; Determines if drug is Safe
PHASE 1
40
Post-Marketing Surveillance; Drug Approved for Circulation; Watching out for Side Effects/ Adverse Effects of the Drug
PHASE 4
41
"Does it work on patients?"; 20-100 subjects
PHASE 2
42
Randomized double-blind, controlled trials; "Does the drug benefit the intended subjects?"
PHASE 3
43
A drug for a rare disease
ORPHAN DRUG
44
What agent used to hasten excretion in a Weak Base Overdose (Diphenhydramine)
ACIDIFYING AGENT (AMMONIUM CHLORIDE)
45
What agent used to hasten excretion in a Weak Acid Overdose (Aspirin)
ALKALINIZING AGENT (SODIUM BICARBONATE)
46
Vasoconstriction via Alpha 1 Receptors in Smooth Muscles
EPINEPHRINE > NOREPINEPHRINE
47
Inhibit Release of Neurotransmitters via Alpha 2 Receptors in Nerve Terminals
EPINEPHRINE > NOREPINEPHRINE
48
Increase Rate and Contractility via Beta 1 Receptors in the Heart
ISOPROTERENOL > EPINEPHRINE > NOREPINEPHRINE
49
Broncho/ Vasodilation via Beta 2 Receptors in Respiratory Smooth Muscles and Uterus
ISOPROTERENOL > EPINEPHRINE > NOREPINEPHRINE
50
Vasodilation of Renal Blood Vessels via D1 Receptors in Splanchic and Renal Vessels
DOPAMINE
51
Regulate Neurotransmitters via D2 Receptors in Nerve Terminals of CNS
DOPAMINE
52
Bowel and Bladder Atony
BETHANECOL (Direct Acting Muscarinic Agonist at M2-M3)
53
Sjogren Syndrome (Xerostomia, Xerophthalmia & Rheumatoid Arthritis)
PILOCARPINE (Direct Acting Muscarinic at M1, M2, M3)
54
Diagnosis of Myasthenia Gravis, Differentiation of Myasthenic and Cholinergic Crisis)
EDROPHONIUM (Indirect Acting Cholinomimetic) MOA: Hydrolysis of Cholinesterase
55
Treatment of Myasthenia Gravis
NEOSTIGMINE
56
Reversal of Nondepolarizing Neuromuscular Block
NEOSTIGMINE
57
Treatment of Glaucoma (Cholinergic Drug)
PHYSOSTIGMINE
58
Diagnosis of Bronchial Hyperreactivity
METHACOLINE (Direct Acting Cholinomimetic)
59
Treatment of Alzheimer's Disease
DONEPEZIL (Reversible Acetylcholinesterase Inhibitor)
60
Bowel and Bladder Atony
BETHANECOL
61
Autoimmune disorder characterized by triad of 1. Xerostomia (Dry Mouth) 2. Xerophthalmia (Dry Eyes) 3. Rheumatoid Arthritis
SJOGREN SYNDROME
62
Autoimmune destruction of nicotinic acetylcholine receptors characterized by fluctuating muscle weakness: 1. ocular symptoms 2. bulbar symptoms 3. proximal muscle weakness
MYASTHENIA GRAVIS
63
Acute worsening of symptoms due to infection, stress or UNDERmedication
MYASTHENIC CRISIS
64
Excessive activation of cholinoreceptors (skeletal muscle weakness and parasympathetic signs) due to OVERmedication
CHOLINERGIC CRISIS
65
Differentiate MYASTHENIC CRISIS from CHOLINERGIC CRISIS using EDROPHONIUM
EDROPHONIUM IMPROVES muscle strength in MYASTHENIC CRISIS while it WEAKENS muscle strength in CHOLINERGIC CRISIS
66
Small Cell Cancer presenting with a Myasthenia-like Paraneoplastic Syndrome
LAMBERT-EATON SYNDROME (Destruction of Presynaptic Voltage-Gated Calcium Channels by Antibodies)
67
What are signs and symptoms of Organophosphate Poisoning
DUMBBELSS: Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation (Skeletal Muscles and CNS), Lacrimation, Sweating, Salivation
68
Induction of Mydriasis and Cyclopegia
TROPICAMIDE
69
Sinus Bradycardia
ATROPINE
70
Cholinergic Antagonist used as 2nd Line Treatment for Parkinson's Disease; Improves tremors
BENZTROPINE
71
Cholinergic Antagonist for COPD
IPRATROPIUM (M3 Antagonist)
72
Motion Sickness, Sea Sickness
SCOPOLAMINE
73
Gastrointestinal Spasms
HYOSCYAMINE
74
Treatment for Organophosphate Poisoning/ Nerve Gas Poisoning
ATROPINE (Reverses effect of Acetylcholine esp Muscarinic Effects) & PRALIDOXIME (given first; 6-8 hours effect duration)
75
Muscarinic Antagonists for Parkinson's Disease
TRI to park your BENZ, BIP here: TRIhexyphenidyl, BENZtropine, BIPeriden
76
Why is Ipratropium the preferred bronchodilator in patients with comorbid COPD and Heart Disease?
IPRATROPIUM less likely to cause tachycardia and cardiac arrhythmias
77
Signs of Atropine Toxicity
HOT as a hare, DRY as a bone, RED as a beet, BLIND as a bat, MAD as a hatter; CI: Infants, BPH, Acute-Angle Closure Glaucoma
78
DOC for Anaphylactic Shock, Adjunct to local anesthesia, Cardiac Arrest, Croup
EPINEPHRINE (Equal affinity to Alpha & Beta Receptors; Acts like a HORMONE)
79
Acute CHF, Cadiac Stress Testing
DOBUTAMINE (β1)
80
Acute CHF, Shock (Cardiogenic, Septic)
DOPAMINE
81
Drug of Last Resort for Shock
NOREPINEPHRINE (α1, α2, β1); Acts like a Neurotransmitter
82
Nasal Congestion, Mydriasis WITHOUT Cycloplegia
PHYNELEPHRINE
83
SE: Rebound Hypertension on Discontinuation
CLONIDINE
84
SE: Hemolytic Anemia (Positive Coomb's Test)
METHYLDOPA (Centrally Acting for Preeclampsia)
85
Bronchial Asthma, COPD
SALBUTAMOL (Selective β2-agonist)
86
Tocolysis for Preterm Labor
TERBUTALINE
87
You have 1 HEART and 2 LUNGS
β1 for HEART, β2 for LUNGS
88
Preoperative treatment of Pheochromocytoma
PHENOXY- BENZAMINE (Irreversible Nonselective; for UNRESECTABLE tumor)
89
Treatment of Rebound Hypertension in Pheochromocytoma
PHENTOLAMINE
90
BPH (SE: First Dose Orthostatic Hypotension)
PRAZOSIN
91
Angina Prophylaxis, Migraine Prophylaxis, Hyperthyroidism, Masks Hypoglycemia in DM
PROPRANOLOL (Nonselective Beta Blocker)
92
SE: Bronchospasm, Erectile Dysfunction
PROPRANOLOL (Nonselective Beta Blocker)
93
Intrinsic Sympathomimetic Activity
PINDOLOL
94
Beta-1 Selectivity
ATENOLOL, METOPROLOL
95
Treatment of Glaucoma
TIMOLOL, PILOCARPINE, ACETAZOLAMIDE, NEOSTIGMINE
96
Combined Alpha- and Beta- Blockade
LABETALOL
97
Drugs to Control BP in Pheochromocytoma
PHENOXY- BENZAMINE, PHENTOLAMINE, LABETALOL
98
Pharmacologic Advantage of α1 Selectivity
Reflex Tachycardia is less common and less severe
99
NOT a Beta Blocker but a Nonselective Beta Agonist
ISOPROTERENOL is a nonselective beta agonist: I SOrry! Akala ko Beta Blocker ka!
100
Intrinsic Sympathomimetic Activity
PINDOLOL, ACEBUTOLOL; ISA pa!
101
Beta Blocker with Longest Half-Life
NADOLOL: Nasa DOLO
102
Beta Blocker with Shortest Half-Life
ESMOLOL: ESMOL (Small)
103
Formula for BP
BP= CO x SVR
104
Expanded Formula for BP
BP= HR x SV x SVR
105
First-Line Drug for Essential Hypertension
HYDROCHLORO- THIAZIDE (Decreases 10-15 mmHg
106
Hypertension with Comorbid CHF/DM, SE: Cough, Angioedema, CI: Bilateral RAS
ACE-INHIBITORS (Captopril): Maximizes neuroprotective effect
107
ACE-Inhibitor Intolerance
LOSARTAN (ARBs)
108
Hypertension with comorbid BPH
PRAZOSIN
109
Pre-Eclampsia (Maintenance Medication), SE: Hemolytic Anemia (Positive Coomb's Test
METHYLDOPA
110
Pre-Eclampsia (Acute BP Lowering) SE: Reflex Tachycardia, Drug-Induced Lupus
HYDRALAZINE
111
Hypertensive Emergency, SE: Hypertrichosis
PHINOXIDIL
112
Hypertensive Emergency, SE: Cyanide Poisoning
NITROPRUSSIDE
113
Treatment of Cyanide Poisoning
AMYL NITRITE
114
Portion of ETC affected by Cyanide
COMPLEX IV (Cytochrome Oxidase)
115
Antidote for Cyanide Poisoning
INHALED AMYL NITRITE + IV SODIUM NITRITE + IV SODIUM THIOSULFATE
116
Relief of Acute Anginal Attacks, SE: Headache
NITRATES (ISDN, NTG)
117
Angina Maintenance, Vascular > Cardiac Effect; SE: Flushing, Edema, Gingival Hyperplasia
NIFEDIPINE
118
Angina Maintenance, Vascular > Cardiac Effect, Vasospastic Angina, Raynaud's Phenomenon, does NOT cause Gingival Hyperplasia
DILTIAZEM
119
Supraventricular Tachycardia, Cardiac > Vascular Effect; SE: Gingival Hyperplasia
VERAPAMIL
120
Pathophysiology of Throbbing Headaches in Nitrates
Dilation of Meningeal Artery
121
Calcium-Dependent Neurotransmission or Hormone Release NOT affected by CCB
CCBs block L-type Calcium Channels, other functions use N-, P- and R- Types
122
Drugs causing Gingival Hyperplasia
NapaCa-Pangit ng gingiVa mo!: Nifedipine, Cyclosporine, Phenytoin, Verapamil
123
Positive Inotrope for Heart Failure, SE: Arrhythmias (PVC, AVB), RG, Color Blindness, Yellow Visual Halos
DIGOXIN
124
Treatment of Pulmonary Edema in CHF
FUROSEMIDE
125
First-Line Drug for Chronic CHF, Cardioprotective
ACE-INHIBITORS, ARBs
126
Improves Survival (Decrease Mortality) in CHF
ACE-Is/ARBs, Beta Blockers (CI: AHF), Spinorolactone
127
Decreases hospitalization in CHF
DIGOXIN
128
Improves Survival in CHF patients of African-American Descent
HYDRALAZINE + ISDN
129
Drugs shown to improve survival in Heart Failure
ABA! Buhay ka pa!: ACE inhibitors, Beta blockers, Aldosterone antagonist
130
Treatment of all types of Arrhythmias, WPW Syndrome, SE: Drug-Induced Lupus
PROCAINAMIDE
131
SE: Cinchonism (Headache, Tinnitus, Vertigo)
QUINIDINE
132
Post-MI Arrhythmias, Digital Arrhythmias, SE: SEIZURES
LIDOCAINE (1B)
133
Contraindicated Post-MI, Refractory Arrhythmias
FLEICANIDE (1C)
134
Perioperative and Thyrotoxic Arrhythmias, SVT
ESMOLOL
135
SE: Dose-Dependent Torsades de Pointes
SOTALOL
136
Most Efficaceous Anti-Arrhythmic, SE: Skin Deposits, Pulmonary Fibrosis, Hyper/ Hypothyroidism
AMIODARONE (3) Most effective, Most Efficaceous, Most Toxic
137
Outpatient Management of SVT, SE: Gingival Hyperplasia
VERAPAMIL
138
Effects of Class I antiarrhythmics on Action Potential Duration
CLASS IA: prolongs AP duration, CLASS IB: shortens AP duration, CLASS IC: no effect on AP duration
139
Class 1A Anti-Arrhythmics
I am the QUeen who PROClaimed DISO's PYRAMID: QUinidine, PROCainamide, DISOPYRAMIDe
140
Class 1B Anti-Arrhythmics
I buy MEXican TOCA from LIDO: MEXiletine, TOCAinide, LIdocaine; 1B is Best post MI
141
Class 1C Anti-Arrhythmics
1Chicken ay Pagkain For Enrico: Propafenone, Flecainide, Encainide; 1C is Contraindicated post MI
142
Pulmonary Fibrosis, Paresthesia, Tremors, Thyroid Dysfunction, Corneal Deposits, Skin Deposits
AMIODARONE TOXICITY
143
CCBs NOT USEFUL as antiarrhythmics
DIHYDROPYRIDINE CCBs evoke compensatory sympathetic discharge which facilitates arrhythmias rather than terminating them
144
PROCAINAMIDE: PROLONGS AP duration, PROLONGS PR interval, PROLONGS QRS duration, PROLONGS QT interval
CLASS 1A ANTIARRHYTHMICS
145
LIDOCAINE: SHORTENS AP duration, NO EFFECT on normal cells
CLASS 1B ANTIARRHYTHMICS
146
FLECAINIDE: NO EFFECT on AP duration, PROLONGS QRS duration
CLASS 1C ANTIARRHYTHMICS
147
PROPRANOLOL: NO EFFECT on AP duration, PROLONGS PR interval
CLASS 2 ANTIARRHYTHMICS
148
DOFETILIDE: PROLONGS AP duration, PROLONGS QT interval
CLASS 3 ANTIARRHYTMICS
149
VERAPAMIL: NO EFFECT on AP duration, PROLONGS PR interval
CLASS 4 ANTIARRHYTHMICS
150
Acts on PCT, Treatment for Glaucoma and Mountain Sickness, SE: NAGMA, Hepatic Encephalopathy
ACETAZOLAMIDE: ACIDazolamide causes ACIDosis
151
Acts on TAL, Treatment for Pulmonary Edema, Most Efficaceous Diuretics, SE: Ototoxicity, Hypokalemia, Hypocalcemia
FUROSEMIDE (Acts on Na-K-Cl Channel)
152
Acts on DCT, SE: Hyperglycemia, Hyperlipidemia, Hypercalcemia
HCTZ
153
Acts on CCD, SE: Gynecomastia, Hyperkalemia
SPINOROLACTONE
154
Acts on PCT, DCT, CCD; Treatment of Rhabdomyolysis and Increased ICP, CI: Heart Failure
MANNITOL
155
Causes HAGMA
MUDPILES: Methanol, Uremia, Diabetic Ketoacidosis, Paraldehyde, Isoniazid, Lactic Acid, Ethanol, Salicylates
156
NAGMA
HARD-UP: Hyperalimentation, Acetazolamide, Renal Tubular Acidosis, Diarrhea-Ureteral Diversion, Pancreatic Fistula
157
Adverse Effects associated with Loop Diuretics
OH DANG! Ototoxicity, Hypokalemia, Dehydration, Allergy to Sulfa, Nephritis, Gout
158
Adverse Effects of Thiazide Diuretics
THIAZIDE TOXICITIES: HYPER GLUC- Glycemia, Lipidemia, Uricemia, Calcemia
159
Drugs causing Gynecomastia
Some Drugs Create Awesome Knockers: Spinorolactone, Digoxin, Cimetidine, Alcohol, Ketoconazole
160
Treatment of Iron Deficiency Anemia
FERROUS SULFATE
161
Treatment of Megaloblastic Anemia, Vitamin B12 Deficiency
CYANO- COBALAMIN
162
Treatment of Megaloblastic Anemia, Prevention of Neural Tube Defects (Spina Bifida)
FOLIC ACID
163
Treatmetn of Anemia in CKD
ERYTHROPOIETIN
164
Treatment of Neutropenia and Agranulocytosis
FILGRASTIM
165
Treatment of Chemotherapy-Induced Thrombocytopenia
OPRELVEKIN
166
Acute Treatment of DVT, PE and AMI, SE: Bleeding, Thrombocytopenia, Monitor with PTT
HEPARIN
167
Low Molecular Weight Heparin, Less Risk of Thrombocytopenia, Does NOT need monitoring
ENOXAPARIN
168
Treatment of Heparin-Induced Thrombocytopenia
LEPIRUDIN
169
Antidote to Heparin-Induced Bleeding
PROTAMINE SULFATE
170
Chronic Anticoagulation, SE: Bleeding, Skin Necrosis, Many Drug Interactions
WARFARIN
171
Antidote to Warfarin (Immediate Reversal)
FFP
172
Antidote to Warfarin (Reversal over Time)
VITAMIN K
173
Laboratory Test to Assess Extrinsic and Intrinsic Coagulation Pathways
PiTT, PTT for INTRINSIC PATHWAY; PeT, PT for EXTRINSIC PATHWAY
174
Overlap between Heparin and Warfarin
1. Warfarin's effect requires elimination of preformed clotting factors (8-60 hours) 2. Bypass the initial prothrombotic effect of Warfarin (Skin Necrosis)
175
Thrombolysis in AMI, Ischemic CVD and PE, SE: Bleeding
R-tPA, ALTEPLASE
176
Bacteria-Derived Thrombolytic, Decreased effect on subsequent uses due to Antibody Formation
STREPTOKINASE
177
Antidote to Thrombolytic Overdose
AMINOCAPROIC ACID (Tranexamic Acid)
178
Irreversible COX Inhibitor, Instant prevention of Arterial Thrombosis, SE: Tinnitus, Hypersensitivity, Reye Syndrome
ASPIRIN
179
ADP Inhibitor, Additive Effects with Aspirin
CLOPIDOGREL
180
Glycoprotein IIb-IIIa Inhibitor
ABCIXIMAB
181
Phosphodiesterase Inhibitor, Cardiac Stress Testing
DIPYRIDAMOLE
182
How many 500mg Aspirin tablets must be ingested to produce TOXICITY? DEATH?
TOXIC DOSE: 150 mg/kg; 150mg x 70kg/ 500mg per tab = 21 TABLETS; LETHAL DOSE: 500mg/kg; 500mg/kg x 70 kg / 500mg per tab = 70 TABLETS
183
Triad of Aspirin Hypersensitivity
SAMTER TRIAD: Asthma, Aspirin Sensitivity, Nasal Polyp
184
Signs of ASA Poisoning
ASPIRIN POISONING: C-H-A-F-S - Coma, Hyperventilation, Acidosis (HAGMA), Fever, Seizure
185
Expected Acid-Base Abnormality in Salicylate Poisoning
RESPIRATORY ALKALOSIS with HAGMA
186
Difference of Aspirin Intoxication Presentation in Children and Adults
ADULTS: Mixed Acid-Base Disorder, Respiratory Alkalosis with HAGMA; CHILDREN: Pure Acid-Base Disorder, HAGMA
187
Difference between Inhibitor and Uncoupler in Oxidative Phosphorylation
INHIBITORS: Completely halt ETC; UNCOUPLERS: Dissipate Proton Gradient without interrupting ETC
188
HmG-CoA Reductase Inhibitor, Lowers LDL; SE: Hepatotoxicity, Rhabdomyolysis, Myopathy
SIMVASTATIN
189
Bile Acid Binding Resin, Lowers LDL, SE: Constipation, Steatorrhea
CHOLES- TYRAMINE
190
Cholesterol Absorption Blocker, Lowers LDL
EZETEMIBE
191
Reduces all building blocks for hyperlipidemia, Increases HDL, Lowers LDL and TG, SE: Flushing, Hyperglycemia, Hyperuricemia
NIACIN (VITAMIN B3)
192
PPAR-α activator, Upregulates lipoprotein lipase, Lowers TG, SE: Gallstones, Additive Myopathy
GEMFIBROZIL
193
Purpose of Statin Use in Management of Coronary Artery Disease
STABILIZATION OF ATHERO- SCLEROTIC PLAQUE
194
Drugs that Cause Flushing
VANCOMYCIN, ADENOSINE, NIACIN, CCBs
195
Irreversibly inhibits Cyclooxygenase 1 and 2
ASPIRIN
196
Reversible inhibitor of Cyclooxygenase 1 and 2
NSAIDs (IBUPROFEN)
197
Irreversibly inhibits Cyclooxygenase 2
CELECOXIB
198
Reversibly inhibits Cyclooxygenase 1 and 2, Antipyretic of Choice in Pediatric population
PARACETAMOL (associated with Acute Hepatic Failure sec to Overdose)
199
Treatment of hypersensitivity (Food allergy, rhinitis, hay fever, angioedema), SE: Sedation
DIPHEN- HYDRAMINE
200
Adjunct for motion sickness, Vertigo
MECLIZINE
201
Treatment of hypersensitivity, non-sedating
CETIRIZINE
202
Treatment of Peptic Ulcers, SE: Gynecomastia
CIMETIDINE (H2 Blocker)
203
DOC for Migraine and Cluster Headache
SUMATRIPTAN
204
Treatment for Postop and Post-Chemo Vomiting
ONDANSETRON
205
Adjunct for Migraine and Cluster Headache
ERGOTAMINE (Vasoselective)
206
Treatment for Postpartum Bleeding
ERGONOVINE
207
SE: Retroperitoneal Fibrosis
METHYSERGIDE
208
PGE1 Analogue for Erectile Dysfuntion, Maintain Patency of PDA
ALPROSTADIL
209
PGE1 Analogue for NSAID-Induced Gastritis; Abortifacient
MISOPROSTOL
210
PGEF2A Analogue for Chronic Glaucoma
LATANOPROST
211
PGE2 Analogue for Cervical Ripening; Abortifacient
DINOPROST
212
PGF2A Analogue; Abortifacient
CARBOPROST
213
PGI2 Analogue for Pulmonary Hypertension
EPOPROSTENOL
214
DOC for Acute Asthma Attacks
SALBUTAMOL/ ALBUTEROL (Short Acting)
215
Adjunct for Asthma Maintenance
SALMETEROL (Long Acting)
216
Prophylaxis for Nocturnal Asthma, SE: Seizures, ANT: Propranolol
THEOPHYLLINE (Methylxanthines)
217
Bronchodilator of Choice in COPD
IPRATROPIUM (Mediators; Proinflammatory)
218
Stabilizes mast cells, No bronchodilator effect
CROMOLYN
219
DOC for Asthma Maintenance, SE: Oral Candidiasis, Growth Stunting
FLUTICASONE (Inhaled Steroid)
220
Lipoxygenase Inhibitor, SE: Increased AST/ALT
ZILEUTON
221
Blocks slow-reacting substances of anaphylaxis (Leukotrienes C4, D4, E4)
MONTELUKAST
222
Drugs with Zero Order Kinetics
WHAT PET: Warfarin, Heparin, Aspirin, Tolbutamide, Phenytoin, Ethanol, Theophylline
223
Drug exhibitin Tachyphylaxis
NICO DESperately HYDs his EPHic LSD with CALCI on the DOBly special NIT that they MET: NICOTINE, DESMOPRESSIN, HYDRALAZINE, EPHEDRINE, LSD, CALCITONIN, DOBUTAMINE, NITROGLYCERIN, METHIONINE
