Pharma of mood stabilisers

Question 1

types of mood stabilisers

Answer 1

anti convulsants - carbamazepine, valproate, lamotrigine

atypicals - olanzapine, risperidone, aripiprazole, quetiapine

others - lithium, nimodipine

Question 2

lamotrigine - how does it work

Answer 2

lamotrigine has anticonvulsants effects by blocking NA channels
can also inhibit 5HT

Question 3

lithium in clinical practice

Answer 3

high incidence of adverse effects and risk of inadvertent toxicity

toxicity in overdose

problems with adherence

requires blood monitoring

Question 4

typical anti psychotics

Answer 4

DA blockade

Question 5

second generation anti psychotics

Answer 5

increased D2 receptor binding affinity increases anti psychotic effectiveness

increased 5HT2c and 5HT 2a receptors binding affinities increases antipsychotic efficacy

increased 5HT 1a receptors binding affinity reduces antipsychotic efficacy

Question 6

what are second gen atypicals less likely to do than typical

Answer 6

less likely to induce extra pyramidal side effects