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Pharmacology 2 midterm from 30 NOV > Pharma MCQ NATA TEST > Flashcards

Pharma MCQ NATA TEST Flashcards

1
Q

What is the physical state of a dispersed phase in a suspension ?

A. Solid
B. Liquid
C. Both
D. None of them

A

A. Solid

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2
Q

Which of the following is characteristic of pastes?

A. Each of these
B. High lipid content
C. High dry material
D. High Water content

A

C. High Dry material

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3
Q

The EV admin of this anaesthetic drug causes strong tissue irritation?

A.Pentobarbitol
B. Ketamine
C. TileTamine
D. Antipamezole

A

C. Tiletamine also Imidazoles causes!

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4
Q

Its analgesic activity is negligible ?

A. Xylazine
B. Ketamine
C. Buprenorphine
D. Thiopental

A

D. Thiopental (used for induction anaesthesia for short procedures)

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5
Q

What is the goal of pharma investigations in drug research?

A. Determination of mechanism of effect
B. Repeated dose toxicity
C. Bioequivalence studies
D. Target animal tolerance

A

A. Determination of mechanism of effect

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6
Q

Which investigation belongs to the clinical phase?

A. Food safety
B. Field trial
C. Pharmacological study
D. Environmental toxicity

A

B. Field trials (used on diff. groups of sick animals/ stages of illness)

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7
Q 
This ultrashort barb. can be readmin. in one day? 
A. Pentobarbitol 
B. Thiamilal 
C. Methohexital
D. Thiopental
A

C. Methohexital

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8
Q

Which vehicle is a useful preparation for eye ointment?

A. simple ointment
C. Cocoa butter
C. Paraffin
D. White vaseline

A

D. White vaseline

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9
Q

This type of gen. ana has a pronounced analgesic effect ?

A. Inhalation anaesthetic
B. Ultra short acting barbs
C. Steroid anasthetics
D. Dissociate anaesthetics

A

D. Dissociate anaesthetics (ketamine, tiletamine)

NONE Of the others have Analg.

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10
Q

Alpha 2 agonist not used in horses?

A. Medetomidine
B. ROMIFIDINE
C. Detomidine
D. Xylazine

A

A. Medetomidine (for Car, effects like xylazine)

HORSE uses Detomidine !

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11
Q

Which alpha 2 agonist is useful in swine ?

A. Medetomidine
B.Detomidine
C. None of them
D. Both

A

C. None of them

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12
Q

In the course of registration of licensed EUDRALEX medicines which safety documentation?

A. part 4
B. Part 3
C. Part 2
D. Part 1

A

C. Part 3

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13
Q

Which is the formulation type of Cremor Auqaporous?

A. Solution
B. O:W emulsion
C. W:O emulsion cream
D. Suspension type

A 
B. O:W with separate lipid and separate solid phase 
O:W emulsifier: sodium lauryl sulphate 
Purified water
Glycerol
and lipid emulsifier Cetosteryalcohol
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14
Q

What matrices are investigated in a P.kinetic exam?

A. Urine
B. Edible tissue
C. Blood
D. Blod, Urine, faeces, Milk, egg

A

D. Blood, urine, Faeces, milk, egg

Edible tissue is examined in the residue study

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15
Q

Which parameter has to be determined in an acute oral toxicity study ?

A. GHS class - Global Harmonized classification
B. TD 50
C. ED 50
D. Bioequivalence

A

A. GHS class possible TD 50 but not mentioned in class notes!

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16
Q

Which of the following is a water soluble base?

A.Soft parrafin
B. Hydroxyaethylcellulose
C. Cocoa butter
D. Vaseline

A

B. HYDROXYAETHYLCELLULOSE

17
Q

Which of the following is not true?

A. Local tolerance study examines alterations at site of exposure
B. Tetragenic studies examine abnormalities of the embryo
C. Mutagenic examines structural and numerical changes of the chromosomes
D. Pharmacological examines movement of the drug within the body

A

D. Pharmacological examines the main mechanisms of effect MECHANISM OF ACTIOn (effect on organ system)

18
Q

The DOA of propofol in dogs is?

A. 15-20 mins
B. 20- 45 mins
C. 20 -30 mins
D. 5- 8 mins

A

A. 15- 20 mins (Fe up to 30 mins)
ONLY GIVEN IV!
sensitive to microbial infection!

19
Q

If the aim of these investigations is to determine the accelerated stability of the
product what are the appropriate conditions?
A. Room temp 0-3 months
B. Room temp 0- 4 weeks
C. 40 Degrees C 75 % RH 0-6 months
D. Room temp 0-24 hours

A

C. 40 C 75 % RH 0-6 months

20
Q

Which is emulsifying agent?

A. Coca Butter
B. Purified water
C. Preservatives
D. Polysorbate 20

A

B. Purified water

Polysorbate is a synthetic water soluble ointment

21
Q 
This general anaesthetic drug can cause dose dependent reversible respiratory inhibition ? 
A. Aflaxon 
B. Etomidate 
C. Ketamine
D. Thiamilal
A

D. Thiamilal (accumulate in the fat no readmin!) 5-8 min duration

22
Q 
Antidote for xylazine and medetomidine? 
A. Anitipameole
B.Samazenile
C.Fluanisone
D. Fluamazenile
A

A. ANTIPAM = alpha 2 antidote to wake up!

23
Q 
Which drug is a coherent colloid? 
A.Ointment
B. cream 
C. Gel 
D. Paste
A

C. GEL

Others = heterogenous coherent!

24
Q

What is a major side effect of inhalation aesthetics?

A

ISOF- local irritation, bronchospasm

no isoflourane for induction!

25
Q 
Its cardiovascular side effects are negligible ? 
A. Xylazine
B. Diazepam
]C. Propofol
D. Pentobarbitol
A

B. Diazepam

Xylazine= brady cardia AV block
Propofol- Neg. inotropic effect Arrythmia
Pentobarbitol= Cardiovascular Depression & Tachycardia

26
Q

Which drug has pronounced analgesia?

A. Propofol
B. Ketamine
C. Etomidate
D. Pentobarbitol

A

B. Ketamine

Pentobarbitol does have analgesic properties but must be used in combo!

27
Q

Which is a lipophilic suppository base?

A. Hard fat
B. Talc
C. Macrogol mixture
D. Castor Oil

A

A. Hard Fat

Macrogol is hydrophilic synthetic
castor oil is for an ointment vehicle

28
Q

their depth of sedation is well related to the applied dose?

A. Tranquilizers
B. Butyrophenones
C. Phenothiazines
D. Alpha 2 receptor agonists

A

D. A2 receptor agonists (the sedative hypnotics)

Tranqs - dose response is not predictable

29
Q

Which of the following are not water sol bases?

A. Both
B. Sunflower oil
C. Wool fat
D. Neither

A

A. Both!

30
Q 
Which of the following are non water soluble vehicles? 
A. Hydrophilis ointment base
B. Both of them 
C. Neither 
D. Hydrous ointment base
A

D. Hydrous ointment base is water insolvent = lanolin

Hydrophillis ointment is water sol ex CETOMACROGOL and emulsifying wax

Pharmacology 2 midterm from 30 NOV (2 decks)

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