Pharma Lab 5: Endocrine Drugs

Question 1

why do we use hormones?

Answer 1

to treat hormone deficiency / overprod

to treat hormonal diseases

synchronise/ suppress oestrus

induce parturition / abortion

myometrial stimulant / relaxant

Question 2

Name 3 forms of insulin

Answer 2

swine origin caninsulin
human Prozinc
Human Rapid

Question 3

What are the levels of duration of insulin products

Answer 3

rapid –> semilente –> lente –> ultralente

Question 4

indications of insulin

Answer 4

DM Type 1
DM Type 2
Cattle Ketosis

Question 5

Side effects of insulin treatment?

Answer 5

Hypoglycaemia
Allergic reactions
Somogyi Rebound Effect

Question 6

What type of DM can antidiabetics treat?

Answer 6

DM Type 2

Question 7

What drugs are suitable as oral antidiabetics

Answer 7

Acarbose (tablet)
Sulfonylureas (Gipizide PO)

Question 8

What 3 drug groups can act on the adrenal cortex

Answer 8

GCC
Mineralocorticoids
Gonadocorticoids

Question 9

What drug can be used to treat Addisons Diseases?

Answer 9

Fludrocortisone

Question 10

What drug can be used to treat Cushings Syndrome?

Answer 10

Pituitary induced hypercortisolism: Trilostane

Adrenal Gland induced hypercortisolism: Trilostane, Ketoconazole.

Question 11

Name 2 drugs used to treat hypothyroidism

Answer 11

Levothyroxine
Liothyronine

Question 12

Name 2 drugs used to treat Hyperthyroidism

Answer 12

Methimazol / Tiamazol

Question 13

Name 4 analogues of GnRH

Answer 13

buserelin
fertirelin
gonadorelin
deslorelin

Question 14

Name an analogue of FSH

Answer 14

eCG - equine chorium gonadotropin

Question 15

Name an analogue of LH

Answer 15

hCG - human chorium gonadotropin

Question 16

What is a suitable product for small animals to stimulate gonadal function?

Answer 16

Suprelorin Implant

Question 17

What are 3 suitable products to stimulate gonadal functions in farm animals

Answer 17

Receptal inj
Depherelin inj
Fertagyl inj

Question 18

What type of hormones are suitable for oestrus synchronisation / suppression?

Answer 18

Progestogens / Progestagens

Question 19

Name 4 Progestogens / progestagens in generation 1

Answer 19

Progesterone
MPA
norgestomet
flurogestone altrenogest

Question 20

Name 2 progestogens / progestagens in the 2nd generation

Answer 20

proligestone
megestrol acetate

Question 21

What progestogen product can be used in sheep and goat

Answer 21

Chronogest CR controlled release vaginal sponge.
contains Flurogestone

Question 22

What progestagen product can be used in cattle

Answer 22

Crestor implant and inj
Contains norgestomet + oestradiol

Question 23

What progestagen product can be used in equine?

Answer 23

Regumate oral solution.
Contains altrenogest

Question 24

What progestogen product can be used in sheep dog and cat?

Answer 24

Depo-promone inj AUV - Provera tablet.
Contains MPA

Question 25

What progestogen product can be given inj to dog and cat

Answer 25

Covinian inj Contains proligestone

Question 26

What progestogen product can be given PO to dog and cat

Answer 26

Ovarid tablet megestrol tablet

Question 27

What hormone can be used for oestrus synchronisation?

Answer 27

Prostaglandin

Question 28

What 4 analogues of Prostaglandin are available

Answer 28

Cloprostenol Dinoprost Etiprosten Luprostiol

Question 29

What hormones/ drugs can be used for the induction of parturition / abortion

Answer 29

- Prostaglandin + Dex - Progesterone Antagonist -> Aglepriston - Ergolides: Cabergoline, Bromocriptine

Question 30

What type of inhibitors can be used as antiandrogens?

Answer 30

5alpha-reductase inhibitors Steroid receptor inhibitors

Question 31

What hormones are cause myometrial stimulus?

Answer 31

Prostaglandins Oxytocin Carbetocin

Question 32

What hormones are myometrial relaxants?

Answer 32

Beta2 adrenoreceptor agonists, Antispasmodics