Pharma L1 Pituitary Drugs Flashcards
Use of CRH ?
Diagnostic: differentiate between Cushing’s and ectopic ACTH producing cells
ACTH uses
Diagnostic: differentiate between Addison’s and secondary adrenal insufficiency (low ACTH secretion)
ACTH is given, cortisol remains low and ACTH is high whats the disease?
Addison’s
2ry adrenal insufficiency
ACTH is given —>cortisol is increased, low plasma ACTH
Somatropin PKs?
Given SC/IM, HL= 25 min, however stimulates IGF-1 secretion prolonging action
Uses of Somatropin
Growth failure, Prader-Willi syndrome (Cr 15 deletion), AIDS muscle wasting
Off-label: anti-aging, athletes
S/E of Somatropin
Arthralgia, cardiomegaly, myalgia, risk of diabetes (C/I in diabetics), edema
Octreotide & Lanreotide PKs?
They’re synthetic analogues of somatostatin. Given IV & depot once a month, longer HL than GHIH
Uses of octreotide and lanreotide
Acromegaly, diarrhea and flushing caused by tumor, Esophageal varices hemorrhage.
S/E of Octreotide & Ianreotide
Nausea, steatorrhea, Gallstones (inhibits pancreatic enzymes secretion)
Pigvisoment
GH receptor antagonist. Used to treat refractory (unresponsive) acromegaly given SC
Bromocriptine
D2 (dopamine) receptor agonist —> inhibits prolactin —> treats hyperprolactinemia & type 2 DM
Metoclopromide
Dopamine antagonist (antipsychotic) —> increases prolactin secretion
Uses of Oxytocin
Induce labor, prevents postpartum hemorrhage, milk ejection
S/E of oxytocin
Anti diuretic effect (water retention), hypertension, uterine rupture (C/I in previous C-section)
