PHARMA EXAM Flashcards

1
Q

*AMOXICILLIN

A

Amoxicillin

Use/Indication:
- Bacterial infections (e.g., respiratory, ear, urinary tract)

Route(s):
- Oral

Side effects:
- Nausea, diarrhea, rash, allergic reactions

Contraindications:
- penicillin allergy

Cautions:
- Caution in renal impairment
- Monitor for signs of superinfection or allergic reactions

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2
Q

*OMEPRAZOLE

A

Use/Indication: GERD, peptic ulcers,

Route(s): Oral, IV

Side effects: Headache, nausea, diarrhoea, abdo pain

Contraindications: Hypersensitivity (Allergy), liver impairment

Cautions/Nursing Considerations: Monitor liver function, give 30 min before meals
Use cautiously in pregnancy and breastfeeding

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3
Q

*MORPHINE

A

Morphine

Use/Indication:
- Severe pain relief

Route(s):
- Oral, IV, IM, subcutaneous

Side effects:
- Sedation, constipation, nausea, LOW respiratory rate

Contraindications:
- Respiratory depression, acute abdominal conditions, hypersensitivity

Cautions:
- Monitor for respiratory depression, especially with high doses
- Caution in elderly, renal/hepatic impairment, and opioid tolerance

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4
Q

*SODIUM VALPROATE

A

Use/Indication: Epilepsy, bipolar disorder, migraine prevention

Route(s): Oral, IV

Side effects: Drowsiness, nausea, tremor, weight gain, liver toxicity

Contraindications: Hepatic impairment, urea cycle disorders, pregnancy (unless necessary)

Cautions: Monitor liver function, especially in the first 6 months in pregnancy (teratogenic) and with other CNS depressants

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5
Q

*PARACETAMOL

A

Paracetamol (Acetaminophen)

Use/Indication:
- Pain relief, fever reduction

Route(s):
- Oral, IV

Side effects:
- Liver toxicity (in overdose), rash (rare)

Contraindications:
- Severe liver disease, hypersensitivity

Cautions:
- Weight of patient (under 50kg)
- Avoid alcohol use, monitor liver function with prolonged use
- Caution in renal impairment

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6
Q

*PREDNIDSOLONE

A

Prednisolone

Use/Indication:
- Inflammation, autoimmune disorders, allergies

Route(s):
- Oral, IV, IM

Side effects:
- Weight gain, fluid retention, increased blood sugar, mood changes

Contraindications:
- Systemic fungal infections, live vaccines

Cautions:
- Monitor for signs of infection, blood sugar, and bone health
- Taper dosage to avoid withdrawal symptoms

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7
Q

*IBUPROFEN

A

Ibuprofen

Use/Indication:
- Pain relief, inflammation, fever

Route(s):
- Oral, IV

Side effects:
- Stomach upset, gastrointestinal bleeding

Contraindications:
- Active peptic ulcer, severe renal or liver impairment

Cautions:
- Use lowest dose for shortest duration
- Caution in cardiovascular, GI, and renal conditions

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8
Q

*SALBUTAMOL

A

Salbutamol

Use/Indication:
- Asthma, COPD (bronchodilator), used for hyperkalaemia (shifts into cells)

Route(s):
- Inhalation (MDI, nebulizer), oral

Side effects:
- Tremor, tachycardia, headache, nervousness

Contraindications:
- Hypersensitivity

Cautions:
- Use cautiously in heart disease or hypertension
- Overuse may lead to decreased effectiveness and increased side effects

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9
Q

*CITALOPRAM

A

Use/Indication:
- Depression, anxiety

Route(s):
- Oral

Side effects:
- Nausea, insomnia, sexual dysfunction, dry mouth

Contraindications:
- Hypersensitivity, MAO inhibitors

Cautions:
- Monitor for suicidal thoughts, QT prolongation risk

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10
Q

*SERTRALINE

A

Use/Indication:
- Depression, anxiety, OCD, PTSD

Route(s):
- Oral

Side effects:
- Nausea, insomnia, sexual dysfunction, headache

Contraindications:
- poorly controlled epilepsy Hypersensitivity,

Cautions:
- Monitor for suicidal thoughts, serotonin syndrome risk with other serotonergic drugs

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11
Q

ADHERENCE

A

-how well patients follows treatment plan with healthcare professional
- i.e taking right dose, time and way (adherence)

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12
Q

COMPLIANCE

A

degree at which patient obeys healthcare professionals recommendations
- not involved in decision making process

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13
Q

CONCORDANCE

A

collaborative/shared decision making between patient and healthcare professional

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14
Q

COVERT ADMINISTRATION

A

medication given to patient without their knowledge or consent
- for lack of capacity patients dementia after ethical/legal consideration

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15
Q

MENTAL CAPACITY ACT

A

States a patient lacks capacity if:
No understanding, retain or use info (dementia reviewed by specialist)

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16
Q

non-malificence
beneficence
autonomy
justice

A

non-malificence - cause no harm - do no harm to patients risks/benefits etc
beneficence - do good acting in best interests
autonomy - patients own decision about healthcare informed consent etc
justice - fairness between patient and healthcare - equality

17
Q

ANTIMICROBIAL STEWARDSHIP

A

strategy to promote responsible use of antibiotic drugs
-prevents misuse/overuse
-reduce AMR - which increases treatment failure
-effective treatments for infections
-reduce side effects/prevent harm
5 moments hygeine
patient isolation
education for patient/docs
auditing

18
Q

ADVERSE REACTION TYPES

A

TYPE A: Augmented (expected effects)drowsiness from morphine, tachy from salbutamol)
TYPE B: bizzare unpredictable (ANAphylaxis, Lupus)
TYPE C: chronic (liver damage /scarring)
TYPE D: delayed (skin changes/cancer) longterm meds
TYPE E: end of use (withdrawal symptoms anxious)

19
Q

FIRST PASS EFFECT

A

How the drug is metabolised by the liver after it is absorbed from GI tract to the circulation system 1. liver where enzymes metabolises it reducing its concentration before enters bloodstream (most of GIT takes part of the drug less drug in circuit system)

20
Q

PHARMACOKINETICS

A

What the body does to the drug

absorbed distributed metabolised and excreted

21
Q

PHARMADYNAMICS

A

What the drug does to the body
chemical and physical effects
Cellular and molecular level i.e. receptors acting etc

22
Q

AGONIST

A

Activates receptor to produce chemical response

23
Q

ANTAGONIST

A

Blocks the receptor and chemical reaction from happening