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Pharmacology > Pharma day 2 > Flashcards

Pharma day 2 Flashcards

0
Q

First dose hypotension

A

Prazosin (Doxazosin, Terazosin, Tamsulosin, Silodosin)

Adrenergic Agonist (alpha1 selective blocker)

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1
Q

What do drug should you give to treat Rebound Hypertension?

A

Phentolamine

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2
Q

Beta blocker used for Pheochromocytoma

A

Labetalol

Phenoxybenzamine, Phentolamine

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3
Q

What medications may cause drug induced Lupus?

A 
Its HIPP to have Lupus
Hydralazine
Isoniazid
Procainamide 
Pencillamine
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4
Q

Vasodilator that causes Hypertrichosis

A

Minoxidil

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5
Q

MOA of Verapamil and Nifedipine

A

Blocks L type Ca channels

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6
Q

Non dihydropyridine Ca channel blocker

A

Verapamil

cardiac > vascular

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7
Q

Dihydropyridine Ca Channel Blocker

A

Dipine!!!

Amlodipine, Felodipine, Nicardipine, Nisoldipine

(vascular > cardiac)

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8
Q

Vasodilator with a SE of Cyanide toxicity

A

Nitroprusside

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9
Q

Why are patients with diabetic Nephropathy treated with ACEI / ARB?

A

They dec. albumin excretion and slow progression of microalbuminuria to Macroalbuminuria

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10
Q

MOA of ARBs

A

Blocks Angiotensin (AT1 receptors) in vascular sm and adr. cortex

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11
Q

Teratogenic anti HPN drug

A

ARBs

Losartan Candesartan Telmisartan

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12
Q

Ultrashort acting Vasodilator used for cyanide

poisoning

A

Amyl Nitrate

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13
Q

Monday Disease

A

Amyl Nitrate

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14
Q

Nondihydropyridine with SE of Reynauds Phenomenon

A

Diltiazem

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15
Q

What drugs can cause Gingival Hyperplasia

A 
NPC V
Nifedipine
Phenytoin
Cyclosporine
Verapamil
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16
Q

Drugs that improve survival in Heart failure

A

ABA!
Acei
Betablocker
Aldosterone inh.

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17
Q

AntiMalarial antiarrhytmic

A

Quinidine

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18
Q

anti arrythmic (class) DOC post Mi

A

Ib

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19
Q

Anti arrythmic betablocker with class 3 properties

A

Sotalol

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20
Q

Amniodarone Toxicity

A 
PP TT CS
pulmonary fibrosis
parasthesias
tremors
thyroid dysfunction
corneal and skin deposits
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21
Q

DOC for paroxysmal SVT

A

Adenosine

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22
Q

NAGMA? Non anion Gap Met Acidosis

A 
Hyperalimentation
Acetazolamide
RTA
Diarrhea
Ureteral diversion
Pancreatic Fistula
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23
Q

Synergistic ototoxicity with Aminoglycosides

A

Furosemide

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24
Q

Adverse effects of Loop Diuretics

A 
OH DANG
Ototoxicity
Hypokalemia
Dehydration
Allergy to Sulfa
Nephritis
Gout
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25
Q

Mnemonics for TZD diuretic

A 
Hyper GLUC
Hyperglycemia
Hyperlipidemia
Hyperuricemia
Hypercalcemia
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26
Q

Diuretic that causes Gynecomastia, Impotence, BPH, Hyperchloremic Met. acidosis

A

spirinolactone (eplerinone)

27
Q

Diuretic that causes Acute renal failure if given with indomethacin

A

Amiloride (triameterene)

28
Q

DOC for Hypertriglyceridemia

A

Gemfibrozil

29
Q

Excess production of histamine detected in the urine

A

imidazole acetic acid

30
Q

excess of Serotonin detected in the urine as

A

5 HydroxyIndole Acetic acid (5 H1AA)

31
Q

DOC for Migraine?

A

Sumatriptan

32
Q

Maintains PDA

A

Alprostadil

prostaglandin e1 eicosanoid

e1 mong bukas

33
Q

SE is Intermittent claudication

A

Pentoxifylline

Cilostizole (antiplatelet drug)

34
Q

DOC for Asthma Prophylaxis

A

Fluticasone

35
Q

DOC Status Asthmaticus (Severe Refractory Asthma)

A

IV Hydrocortisone

36
Q

Drug used as prophylaxis for severe refractory asthma

A

Omalizumab

37
Q

hemochromatosis Triad

A

Cirrhosis. DM Skin. pigmentation

38
Q

vitamin b12 is absorbed in the ______

and stored in the _______

A

distal ileum

liver

39
Q

site of Folic acid absorption

A

proximal jejunum

40
Q

Aspirin intoxication HAGMA acronym?

A

MUDPILES

Methanol Uremia Dka Paraldehyde Isoniazid/Iron LacticAcid Ethanol Salicylates

41
Q

samter triad for Aspirin Hypersensitivity

A

Asthma
Aspirin Allergy
Nasal polyps

42
Q

SE associated with Chronic use of heparin

A

osteoporosis

43
Q

Antidote for Alteplase

A

Aminocproic acid (Tranexamic acid : Hemostan)

44
Q

Disease Modifying Anti Rheumatics Drugs may take ___________

for benefits to become apparent.

A

6 weeks to 6 months

45
Q

Rescue agent for methotrexate

A

Leucovorin

46
Q

SE is Pseudolymphomatous reaction

A

Methotrexate (DMARD)

47
Q

Ihibits AICAR transformylase and thymidylate synthetase, with secondary effects of polymorphonuclear chemotaxis

A

Methotrexate (DMARD)

48
Q

SE includes Reactivation of Hepatitis B/Latent Tuberculosis, bacterial infections, Autoantibody formation (ANA and anti-dsDNA)

A

Infliximab (DMARD)

49
Q

DMARD that make cause Severe Leukopenia if given with Allopurinol

A

Azathioprine

50
Q

DMARD that is also an Anti-Malarial

A

Chloroquine

51
Q

True or False… Chloroquine is safe for pregnant women?

A

True

52
Q

DMARD with a SE of Ocular Toxicity

A

Chloroquine

53
Q

Rescue Agent for Cyclophosphamide

A

Mesna

54
Q

DMARD with SE of Hemorrhagic cystitis

A

Cyclophosphamide (phosphoramide mustard)

55
Q

DMARD with SE of Nephrotoxicity, Hypertension, Hyperkalemia, HEpatotoxicity, GINGIVAL Hyperplasia, Hirsuitism

A

Cyclosporine

56
Q

DMARD used for RA, IBD, JRA, Ankylosing Spondiliyis with SE of Hemolytic Anemia, Methemoglobinemia, Anti ds-Dna autoantibody formation and REVERSIBLE infertility in men

A

Sulfasalazine

57
Q

An anti-gout drug that may precipitate flares during early phase of Drug action.

A

Probenecid (uricosuric agent)

Allopurinol (xanthine oxidase inh)

58
Q

First line treatment for chronic gout , tumor lysis syndrome

A

Allopurinol

59
Q

Nonpurine reversible inhiitor of Xanthine Oxidase

A

Febuxostat

60
Q

Hepatotoxicity increased with Statin use

A

Ezetimibe

61
Q

What drug reduces the catabolic rate for HDL?

A

Niacin

62
Q

_____ pre treatment reduces flushing in niacin

A

Aspirin

63
Q

Serotonin (5-HT) is produced from the amino acid _______

metabolized by ___________

A

tryptophan

monoamine oxidase (MAO)

64
Q

Antidote for overdosage to Theophylline

A

Betablockers

Pharmacology (3 decks)

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