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Pharma day 2 Flashcards

0
Q

First dose hypotension

A

Prazosin (Doxazosin, Terazosin, Tamsulosin, Silodosin)

Adrenergic Agonist (alpha1 selective blocker)

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1
Q

What do drug should you give to treat Rebound Hypertension?

A

Phentolamine

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2
Q

Beta blocker used for Pheochromocytoma

A

Labetalol

Phenoxybenzamine, Phentolamine

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3
Q

What medications may cause drug induced Lupus?

A 
Its HIPP to have Lupus
Hydralazine
Isoniazid
Procainamide 
Pencillamine
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4
Q

Vasodilator that causes Hypertrichosis

A

Minoxidil

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5
Q

MOA of Verapamil and Nifedipine

A

Blocks L type Ca channels

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6
Q

Non dihydropyridine Ca channel blocker

A

Verapamil

cardiac > vascular

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7
Q

Dihydropyridine Ca Channel Blocker

A

Dipine!!!

Amlodipine, Felodipine, Nicardipine, Nisoldipine

(vascular > cardiac)

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8
Q

Vasodilator with a SE of Cyanide toxicity

A

Nitroprusside

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9
Q

Why are patients with diabetic Nephropathy treated with ACEI / ARB?

A

They dec. albumin excretion and slow progression of microalbuminuria to Macroalbuminuria

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10
Q

MOA of ARBs

A

Blocks Angiotensin (AT1 receptors) in vascular sm and adr. cortex

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11
Q

Teratogenic anti HPN drug

A

ARBs

Losartan Candesartan Telmisartan

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12
Q

Ultrashort acting Vasodilator used for cyanide

poisoning

A

Amyl Nitrate

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13
Q

Monday Disease

A

Amyl Nitrate

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14
Q

Nondihydropyridine with SE of Reynauds Phenomenon

A

Diltiazem

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15
Q

What drugs can cause Gingival Hyperplasia

A 
NPC V
Nifedipine
Phenytoin
Cyclosporine
Verapamil
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16
Q

Drugs that improve survival in Heart failure

A

ABA!
Acei
Betablocker
Aldosterone inh.

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17
Q

AntiMalarial antiarrhytmic

A

Quinidine

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18
Q

anti arrythmic (class) DOC post Mi

A

Ib

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19
Q

Anti arrythmic betablocker with class 3 properties

A

Sotalol

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20
Q

Amniodarone Toxicity

A 
PP TT CS
pulmonary fibrosis
parasthesias
tremors
thyroid dysfunction
corneal and skin deposits
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21
Q

DOC for paroxysmal SVT

A

Adenosine

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22
Q

NAGMA? Non anion Gap Met Acidosis

A 
Hyperalimentation
Acetazolamide
RTA
Diarrhea
Ureteral diversion
Pancreatic Fistula
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23
Q

Synergistic ototoxicity with Aminoglycosides

A

Furosemide

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24
Adverse effects of Loop Diuretics
``` OH DANG Ototoxicity Hypokalemia Dehydration Allergy to Sulfa Nephritis Gout ```
25
Mnemonics for TZD diuretic
``` Hyper GLUC Hyperglycemia Hyperlipidemia Hyperuricemia Hypercalcemia ```
26
Diuretic that causes Gynecomastia, Impotence, BPH, Hyperchloremic Met. acidosis
spirinolactone (eplerinone)
27
Diuretic that causes Acute renal failure if given with indomethacin
Amiloride (triameterene)
28
DOC for Hypertriglyceridemia
Gemfibrozil
29
Excess production of histamine detected in the urine
imidazole acetic acid
30
excess of Serotonin detected in the urine as
5 HydroxyIndole Acetic acid (5 H1AA)
31
DOC for Migraine?
Sumatriptan
32
Maintains PDA
Alprostadil prostaglandin e1 eicosanoid e1 mong bukas
33
SE is Intermittent claudication
Pentoxifylline Cilostizole (antiplatelet drug)
34
DOC for Asthma Prophylaxis
Fluticasone
35
DOC Status Asthmaticus (Severe Refractory Asthma)
IV Hydrocortisone
36
Drug used as prophylaxis for severe refractory asthma
Omalizumab
37
hemochromatosis Triad
Cirrhosis. DM Skin. pigmentation
38
vitamin b12 is absorbed in the ______ | and stored in the _______
distal ileum | liver
39
site of Folic acid absorption
proximal jejunum
40
Aspirin intoxication HAGMA acronym?
MUDPILES | Methanol Uremia Dka Paraldehyde Isoniazid/Iron LacticAcid Ethanol Salicylates
41
samter triad for Aspirin Hypersensitivity
Asthma Aspirin Allergy Nasal polyps
42
SE associated with Chronic use of heparin
osteoporosis
43
Antidote for Alteplase
Aminocproic acid (Tranexamic acid : Hemostan)
44
Disease Modifying Anti Rheumatics Drugs may take ___________ | for benefits to become apparent.
6 weeks to 6 months
45
Rescue agent for methotrexate
Leucovorin
46
SE is Pseudolymphomatous reaction
Methotrexate (DMARD)
47
Ihibits AICAR transformylase and thymidylate synthetase, with secondary effects of polymorphonuclear chemotaxis
Methotrexate (DMARD)
48
SE includes Reactivation of Hepatitis B/Latent Tuberculosis, bacterial infections, Autoantibody formation (ANA and anti-dsDNA)
Infliximab (DMARD)
49
DMARD that make cause Severe Leukopenia if given with Allopurinol
Azathioprine
50
DMARD that is also an Anti-Malarial
Chloroquine
51
True or False... Chloroquine is safe for pregnant women?
True
52
DMARD with a SE of Ocular Toxicity
Chloroquine
53
Rescue Agent for Cyclophosphamide
Mesna
54
DMARD with SE of Hemorrhagic cystitis
Cyclophosphamide (phosphoramide mustard)
55
DMARD with SE of Nephrotoxicity, Hypertension, Hyperkalemia, HEpatotoxicity, GINGIVAL Hyperplasia, Hirsuitism
Cyclosporine
56
DMARD used for RA, IBD, JRA, Ankylosing Spondiliyis with SE of Hemolytic Anemia, Methemoglobinemia, Anti ds-Dna autoantibody formation and REVERSIBLE infertility in men
Sulfasalazine
57
An anti-gout drug that may precipitate flares during early phase of Drug action.
Probenecid (uricosuric agent) | Allopurinol (xanthine oxidase inh)
58
First line treatment for chronic gout , tumor lysis syndrome
Allopurinol
59
Nonpurine reversible inhiitor of Xanthine Oxidase
Febuxostat
60
Hepatotoxicity increased with Statin use
Ezetimibe
61
What drug reduces the catabolic rate for HDL?
Niacin
62
_____ pre treatment reduces flushing in niacin
Aspirin
63
Serotonin (5-HT) is produced from the amino acid _______ | metabolized by ___________
tryptophan monoamine oxidase (MAO)
64
Antidote for overdosage to Theophylline
Betablockers

Pharmacology (3 decks)

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