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Pharma/Biochem Flashcards

1
Q

Macrolide action on MMC in GIT

A

Motilin agonist

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2
Q

Furosemide+ NSAID

A

Do not combine
Vasodilatory effect of furosemide is inhibited by NSAID.

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3
Q

DOC in Li induced DI

A

Amloride

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4
Q

ENaC activity increase in which disease

A

Liddle’s

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5
Q

NaK2Cl activity affected in!?

A

Barter’s

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6
Q

NaCl activity DT affected in!?

A

Gittleman

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7
Q

Missense mutation

A

Sickle cell anemia

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8
Q

Frame shift mutation

A

Duchene MD
Tay sach

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9
Q

Splice site mutation

A

Gouchers
Marfan

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10
Q

Base Excision Repair (BER)

A

MYUTH

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11
Q

Mismatch repair

A

HNPCC

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12
Q

Nucleotide Excision Repair (NER) defect

A

Xeroderma pigmentosum
Trichothiodystrophy
Cockayne syndrome

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13
Q

Non Homogeneous End Joining (NHEJ) repair defect

A

SCID

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14
Q

3’ to 5’ direction is in

A) DNA Repair
B) RNA editing

A

RNA editing

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15
Q

DOC for Digoxin induced VT

A

Lignocaine

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16
Q

DOC for Digoxin induced SVT

A

Beta blockers

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17
Q

Statin act on which enzyme

A

HMG CoA reductase

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18
Q

Which drug decrease Lipoprotein a

A

Niacin

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19
Q

Late Na channel blocker

A

Ranolazine

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20
Q

MOA of Ivabradine

A

Inhibitor of funny current of SA node

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21
Q

MOA of Nicorandil

A

K+ ATP channel agonist

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22
Q

MOA of Fusadil

A

Rho-kinase inhibitor

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23
Q

MOA of Evolokumab

A

PCSK9 Inh

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24
Q

DOC for Cirrhotic edema

A

Spironolactone

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25
Q

A/E of Triampherene

A

Megaloblastic anemia

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26
Q

DOC for GTCS

A

Valproate

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27
Q

DOC for Absence seizure

A

Valproate

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28
Q

DOC for childhood Absence Sz

A

Ethosuximide

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29
Q

DOC for JME

A

Valproate

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30
Q

DOC for Focal Sz

A

Carbamazepine

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31
Q

MOA of Diazoxide

A

ATP sensitive K+ channel opener

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32
Q

A/E of Diazoxide

A

Hyperglycemia

( D/t hyperpolarisation of Beta cell of pancrease which leads to decreased production of insulin )

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33
Q

DOC for Restless leg syndrome

A

Gabapentin

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34
Q

NMDA antagonist

A

Felbamate

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35
Q

AMPA antagonist

A

Perampanel
Telaampanel
Topiramate

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36
Q

MOA of Ezogabine/Retigabine

A

K+ channel opener

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37
Q

Which type CCB is Ethosuximide

A

T type

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38
Q

Doc for SVT/PSVT + Asthma

A

Verapamil

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39
Q

Doc for A/c Attack of long QT syndrome

A

MgSO4

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40
Q

MOA of Adenosine

A

Ach sensitive K channel Activation

Decrease HR
Decrease Conduction

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41
Q

Doc for SVT/PSVT

42
Q

BlueMan syndrome seeen in

A

Amiodarone

43
Q

BRAF inhibitors

A

Dabrafenib
Vemurafenib

44
Q

Enzyme def. in Von Gierke’s

A

G-6-Phosphatase

45
Q

Enzyme def. in Pompes

A

Lysosoma α 1,4-1,6 glucosidase
(Acid maltase)

46
Q

Enzyme deficient in Cori’s/Forbes

A

Glycogen Debranching enzyme

47
Q

Enzyme def in McArdles and Hers

A

McArdles - Msl Glycogen phosphorylase

Her’s -Liver Glycogen phosphorylase

48
Q

Enzyme def in Taruis

49
Q

Enzyme defect in Mapple syrup Urine d/s

A

Branched Chain alpha keto dehydrogenase (BCKDH)

50
Q

A/e while using Beta blockers for glaucoma

A

Corneal hypoesthesia
Systemic side effects

51
Q

A/e while using Sympathomimetics for glaucoma

A

Lid traction
CNS depression and apnea in children less than two

52
Q

A/E while using PG analogue for glaucoma

A

Eyelash hypertrichosis
Macular edema
Iris pigmentation
Periorbital fat depletion

53
Q

A/E while using miotics for glaucoma

A

Retinal detachment
Cataract

54
Q

A/E while using CA inhibitor for glaucoma

A

Corneal edema
Systemic side effects

55
Q

MOA of metformine

A

AMP kinase stimulation
Decrease insulin resistance

56
Q

MOA of Pioglitazone

A

Activate transcription regulator PPAR-g

57
Q

Drugs causing SIADH

A

Chlorpropamide
Oxcarbamazepine
Vincristine
SSRI
Cyclophosphamide

58
Q

Doc for Actinomyces and Syphilis

A

Penicillin

59
Q

Doc for Listeria

A

Ampicillin

60
Q

Doc for Mastitis

A

Cloxacillin

61
Q

Doc for SSI

A

Cefazolin (first generation)

62
Q

Doc for Neisseria

A

Cefixime/Ceftriaxone

63
Q

Doc for Lyme disease

A

Cefixime/Ceftriaxone

64
Q

Doc for Enteric fever

A

Cefixime/Ceftriaxone

65
Q

Doc for Pseudomonas

A

Ceftazidine

66
Q

Doc for Enterobacter

A

Carbapenems

67
Q

Doc for Acinetobacter

A

Carbapenems

68
Q

Doc for Plague ; Tularemia

A

Streptomycin

69
Q

Doc for Ricketsia

A

Tetracycline

70
Q

Doc for cholera

A

Tetracycline

71
Q

Doc for Atypical Pneumonia ; Mycoplasma

A

Macrolides

72
Q

Doc for Chlamydia

A

Macrolides

73
Q

Doc for Diphtheria ; Pertussis

A

Macrolides

74
Q

Doc for Legionella

A

Macrolides

75
Q

Doc for Burkholderia

76
Q

Doc for Nocardia

77
Q

Doc for Meningococcus

78
Q

Doc for Anthrax

79
Q

Doc for UTI

80
Q

Doc for Travelers Diarrhoea

81
Q

Doc for Cestodes

A

Praziquantel

82
Q

Doc for Trematodes

A

Praziquantel

83
Q

Doc for Liverfluke

A

Triclabendazole

84
Q

Doc Nematodes

A

Albendazole

85
Q

Doc for Hydatid cyst

A

Albendazole

86
Q

Doc for Onchocerca ; Strongyloids

A

Ivermectin

87
Q

Doc for Cryptosporidium

A

Nitazoxanide

88
Q

Doc for Cyclospora ; Isospora

89
Q

Drugs causing Gout

A

“CANT LEAP”

Cancer drugs (Cyclosporine)
Aspirin
Niacin
Thiazide

Loop Diuretics
Ethambutol
Alcohol
Pyrazinamide

90
Q

New FDA approved drug for Duchenne MD

A

-Eteplirsen
-Casimersen

91
Q

Enzyme defect in Phenylketonuria

A

Phenylalanine hydroxylase

92
Q

Enzyme defect in Tyrosinemia Type 1(Tyrosinosis)

A

Fumaryl Acetoacetate Hydrolase

93
Q

Enzyme defect in Maple syrup urine disease

94
Q

Enzyme defect in Homocystinuria Type 1

A

Cystathione Synthase

95
Q

Enzyme defect in Tyrosinemia Type 2

A

Tyrosine transaminase

96
Q

Enzyme defect in Primary Hyperoxaluria

A

Alanine glyoxalate aminotransferase
(Defect in metabolism of glycine)

97
Q

Selenocysteine

A

21st Aā
Co-translational modification
Analogue of Cysteine
Synthesisedvfrome Serine

98
Q

Pauly’s test done for detecting

A

Histidine
(Imidazole ring)

99
Q

Sulfur test is used for detecting which aā

A

Cysteine
(Sulfhydryl gp)

100
Q

Sakaguchi reaction is used to detect

A

Arginine
(Guanidine gp)

101
Q

Xanthoproteic reaction is used to detect

A

Benzene ring of aromatic aā

102
Q

Ninhydrin reaction is used to detect

A

Alpha amino acid

Daily Revision (13 decks)

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