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DnD-Skin/Con/Misc > Pharma A/p/g/g > Flashcards

Pharma A/p/g/g Flashcards

1
Q

Medications that may trigger Psoriasis

A
  • Lithium
  • Beta-blockers
  • antimalarials
  • angiotensin-converting enzyme inhibitor
  • NSAIDs
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2
Q

Hydrating Agents

A
  • Water-in-oil prep
  • oatmeal products
  • ointments
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3
Q

Anti-pruitics

A
  • Antihistamines 1st Gen
  • Antidepressants
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4
Q

Calcineurin Inhibitors

A
  • Cyclosporine
  • Voclosporine
  • Tacrolimus
  • Pimecrolimus
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5
Q

Anti-TNF Drugs

A
  • Entanercept
  • Infliximab
  • Adalimumab
  • Certolizumab pegol
  • Golimumab
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6
Q

Cyclosporine

A
  • suppress t-cell activation
  • inhibit transcription of IL-2
  • inhibit production of cytokines
  • immunosuppression
  • Nephrotoxic, Cancer risk
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7
Q

Tazarotene

A
  • relative selectivity for RARb and RARg
  • inhibit keratinocyte proliferation and differentiation
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8
Q

Mycophenolate

A
  • inhibits inosine monophosphate dehydrogenase
  • inhibit proliferation of T- and B- lymphocytes
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9
Q

Calcipotriene

A
  • slows skin cell growth
  • synthetic vitamin D3
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10
Q

SE

Calcipotriene

A
  • skin irritation, sting, burn
  • Less common: dry skin, peeling, rash, dermatitis, worsening of psoriasis
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11
Q

Anthralin

A
  • reduces rapid growth of skin cells associated with plaque psoriasis
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12
Q

Alefacept

A
  • Binds to CD2 and inhibit leukocyte function antigen 3 and CD2 interaction
  • Prevent antigen binding and T-cell activation
  • Destroys T-lymph causing plaque
  • increase activity of NK cells
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13
Q

SE

Alefacept

A
  • Sore throat, dizziness, cough, nausea, itch, muscle pain, chill
  • injection site pain/ swelling
  • Serious: lymphopenia, infection, cancer, allergic rxn
  • Hepatic: elevate AST/ALT, fatty infiltrate, hepatitis
  • avoid if blood lymphocyte < 250/ml
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14
Q

IL-2

A

Necessary for T-cell activation

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15
Q

Calcineurin inhibitors

A
  • bind to immunophilins
  • blocks effect of calcineurin
  • leads to reduced IL-2 and T-cell prolif
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16
Q

Tacrolimus

A
  • indicated for moderate to severe atopic dermatitis
  • children > 2 y.o. (0.03%)
  • nephrotoxic, hemato/oncological
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17
Q

Pimecrolimus

A
  • mild atopic dermatitis
  • > 2 y.o.
  • Nephrotoxic, neospasms/infection
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18
Q

Acitretin

A
  • transcription regulator
  • reduce keratinocytes differentiation
  • slows cell reproduction
  • reduce epidermal hyperplasia
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19
Q

Target

TNF-alpha

A
  • Certolizumab pegol
  • entanercept
  • adalimumab
  • infliximab
  • golimumab
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20
Q

Target

IL-12 and 23

A

Ustekinumab

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21
Q

Target

IL-23

A
  • tildrakizumab
  • guselkumab
  • ## risankizumab
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22
Q

Target

IL-17

A
  • secukinumab
  • ixekizumab
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23
Q

SE

Ustekinumab

A
  • prevent T-cell activation
  • NVD, headache, tiredness
  • Upper resp. infection
  • flu symptoms
  • ulcer, syncope, body pain/swell
  • cerebal edema
  • allergic rxn
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24
Q

Interferon-gamma

A
  • produced by activated lymphocytes
  • antiviral activity
  • immunoregulatory fuction
  • In psoriasis, effects are absent
25
IL-17
- induced by IL-23 - Pro-inflammatory cytokine - acts synergistically with TNF-a and IL-1 - potent mediator in delayed-type rxn - recruits monocytes and neutrophils
26
# IL-17A blocker Antibody that binds to inflammation-causing protein
- ixekizumab - brodalumab - secukinumab
27
# IL-17A Blocker Antibody against IL-17A
- secukinumab
28
Guselkumab
- selectively inhibits IL-23 - supress inflammatory and immune response
29
# SE Guselkumab
- NVD, headache, stomach flu - Upper resp. infection, fungal skin infection, herpes simplex infection - Inj site rxn - joint pain
30
# TYK2 Inhibitor Deucravacitinib
- selective to TYK2 pathway - fewer risks - inhibit immune response and inflammatory proteins
31
# SE Deucravacitinib
- NVD, fever, sweat, chill, muscle pain - SoB, stomach pain - Frequent/painful urination - Painful skin/ sores
32
Inhibition of PDE4
- increase cAMP, activate PKA - PKA inhibits Nuclear factor of activated cells
33
Apremilast
- PDE4 inhibitor - reduce TNF-a, upregulate IL-10
34
# SE Apremilast
- Headache, back pain, fatigue - NVD - URI, nasopharyngitis - serious: weight loss, severe NVD, depression, suicidal tendencies
35
Medication that trigger acne
- anabolic steroids - sex steroids - corticosteroids - Isoniazids - Lithium - Phenytoin - oral contraceptives
36
Mild Acne
- gentle cleanse - benzoyl peroxide - Low conc. SA
37
Moderate- Severe Acne
- Benzoyl peroxide - Draining large pimples - topical antibiotics - Retinoids - Azelaic acid
38
Retinoic Acid
- increase proliferation of cells - follicle epithelial turnover - decrease in microcomedones - shedding of corneocytes
39
Topical Retinoid SE
- dryness and irritation - skin color change - photosensitivity - red, swelling, crusting, blistering, eruptions - teratogenic
40
Azelaic acid
- treat rosacea and severe acne - competitive inhibitor of mitochondrial oxidoreductases - bacteriostatic - anti-keratinizing
41
# SE Azelaic acid
- burning feeling - peeling skin - dryness, redness - Rare: blister/flaking of skin, iriitation + swelling, tightness/pain in joints, hives, fever, difficulty breathing
42
Dapsone
- blocks complex that forms folate - decrease in folate availability
43
Tetracycline
- block access of amino TRNA complex
44
Erythromycin / Azithromycin
- blocks translocation
45
SMTH-TMP
- blocks PABA
46
Clindamycin
- Blocks peptide synthesis
47
# Gout Probenecid SE
* GI irritation * Allergic dermatitis * nephrotic syndrome * anemia
48
Allopurinol SE
* exacerbate acute gouty attack * GI distress * neuritis * hepatotoxic, interstitial nephritis * Rare: necrotising vasculitis, marrow depression, SJS, cataracts
49
Febuxostat SE
- NVD - rash - arthralgia - increased LFT's
50
Pegloticase SE
* gout flare * nephrothiasis * NVD * rash * upper respiratory infection * dizziness, anemia, fatigue, hypertension * Delayed uticarial injection site rxn
51
Lesinurad SE
- NVD, headache, increased creatinine, GERD, influenza - BBW, risk of renal failure
52
# (-olol) Beta-blockers SE | may develop tolerance
* ocular stinging * redness, photophobia, dry eyes * uveitis * ocular inflammation
53
Adrenergic agonist (epinephrine, dipivifrin)
* headache, tachycardia, arrythmias * HTN, * anxiety, tremor, sweating nervousness
54
# ALPHA 2 ADRENERGIC AGONIST Apraclonidine Brimonidine
* dryness * ocular irritation * headache, fatigue, sedation * Risk: dizziness, Hypotension
55
# (-zolamide) Carbonic Anhydrase Inhibitor SE
* NVD, metallic taste, cramps, GI distress * malaise, fatiue, weight loss, * decreased libido, anorexia * renal stone, renal failure, metabolic acidosis * depression, dementia
56
Cholinergic Agonist
- ocular (varied) - systemic: HTN, NVD, tachycardia, bronchospasm, pulmonary edema, - CI: asthma, retinal detachment, bradycardia, parkingson's, heart failure, epilepsy
57
# (-prost) Prostaglandin Analogs SE
- mild burning, hyperemia, itching - blurred vision, eye pain/discomfort - Darker eye pigmentation - thicker eyelashes
58
Lanoprostene Bunod
- eye redness + discharge, eye irritation, eye pain - change in lashes, pain upon instilling drops

DnD-Skin/Con/Misc (5 decks)

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