Pharma 4 Flashcards
1
Q
Sulfonylurea 1st generation
A
Increase insulin secretion ( block K channels )
Reduce glucagon secretion
Reduce hepatic insulin extraction
2
Q
Increase insulin secretion , 50% excretion in feces , 50% in urea
A
Glyburide
3
Q
Increase insulin secretion and doesn’t affect cvs
A
Glimepiride
4
Q
Repaglinide & nateglinide
A
Low incidence of hypoglycemia
5
Q
Metformin
A
Reduce hepatic glucose output , inhibit gluconeogenesis
Side effects : lactic acidosis
6
Q
Thiazolidenediones
A
Regulate transcription of genes involved in glucose utilization
Causes fluid retention
7
Q
Exenatide
A
Incretin mimetic , GLP-1 analog
Reduce after meal glucagon secretion
Maintain B cell mass
8
Q
Sitagliptin + linagliptin
A
DPP4 inhibitor —> ⬆️ GLP —> stimulate insulin secretion
9
Q
Acarbose
A
Inhibit carb absorption and digestion
