Pharma

Question 1

Used to treat RA & bowel diseases such as crohn’s

Answer 1

Sulfasalazine

Question 2

Competitive inhibition of DHFR

Answer 2

Methotrexate

Question 3

Inhibit AICAR transformylase —> inhibit purine synthesis

Answer 3

Methotrexate

Question 4

Metabolized to mercaptopurine —> inhibit DNA
Has drug interaction w allopurinol

Answer 4

Azathioprine

Question 5

Converted to teriflunomide -> inhibit DHOD -> inhibit pyrimidine this inhibiting RNA synthesis

Answer 5

Leflunomide

Question 6

Leflunomide

Answer 6

Well absorbed orally
Long half life
Active metabolite goes enterohepatic circulation
Risk of hepatic failure

Question 7

inhibit IL-2 & not cytotoxic

Answer 7

Cyclosporin A

Question 8

Phosphoramide mustard which Alkylate DNA and inhibit dna , RNA cross linking

Answer 8

Cyclophosphamide

Question 9

Inhibit JAK

Answer 9

Tofacitinib

Question 10

Bind to TNF - a and inhibit it’s effects
Side effects; upper respiratory infection

Answer 10

Infliximab

Question 11

Inhibit IL-1
Metal chelator in wilsons disease

Answer 11

D-pinicillamine

Question 12

Anti-malaria and used in Sjögren’s syndrome

Answer 12

Chlorquine

Question 13

Drugs that causes bone more suppression

Answer 13

Methotrexate
Azathioprine
Leflunomide
D-penicillamine

Question 14

Drug that doesn’t cause Bone marrow suppression

Answer 14

Cyclosporin - A

Question 15

Irreversible non selective cox inhibitor

Answer 15

Aspirin

Question 16

St high doses causes hyperventilation and res alkalosis

Answer 16

Aspirin

Question 17

What drug interact with aspirin to reduce the rate of absorption ?

Answer 17

Antacids

Question 18

What drug interact with aspirin to increase the risk of bleeding

Answer 18

Heparin

Question 19

What drug interact with aspirin to reduce urate excretion!

Answer 19

Probencid

Question 20

What drug interact with aspirin to increase it half life ?

Answer 20

Naproxen

Question 21

Reye disease is a side effect of which drug ?

Answer 21

Aspirin

Question 22

Non competitive non selective reversible COX inhibitor

Answer 22

Paracetamol (acetaminophen)

Question 23

Paracetamol pathway used for children

Answer 23

Conjugation with sulfate

Question 24

Predominat pathway for paracetamol in adults

Answer 24

Conjugation with glucuronide

Question 25

Competitive non selective reversible cox inhibitor Indol derivative

Answer 25

Indomethacin

Question 26

Competitive non selective cox inhibitor Propionic acid

Answer 26

Ibuprofen Naproxen

Question 27

Competitive non selective cox inhibitor Phenylacetic acid derivative

Answer 27

Diclofenac

Question 28

Selective cox 2 inhibitor Dipyridinyl derivative

Answer 28

Etoricoxib

Question 29

Selective cox 2 inhibitor Pyrazole derivative

Answer 29

Celecoxib

Question 30

Oral synthetic prostaglandin Used to treat and prevent peptic ulcers

Answer 30

Misoprotosol

Question 31

Normalize the hypothalamic’thermostat’ altered by pg’s in the brain Reduce fever by inhibiting PG synthesis

Answer 31

Antipyretic action

Question 32

Alleviate pain by removing hyperalgesic effects of PGs

Answer 32

Analgesic action

Question 33

Prevent thrombosis by reducing formation of platelet aggregating theomboxane A2

Answer 33

Aspirin

Question 34

Effect of inhibiting cox 2

Answer 34

Decrease the release of anti-aggregatory prostaglandin I2 But it does not affect Thromboxane bcz it lacks cox2

Question 35

PTH synthetic analog increases osteoblast proliferation, differentiation and activity o for parenteral treatment of osteoporosis

Answer 35

Teriparatide

Question 36

1αHydroxyvitamin D2 , converted in the liver to 1,25dihyroxyvitamin D active form of Vit D that selectively inhibits PTH formation

Answer 36

Doxercalciferol

Question 37

19nor1,25dihydroxyvitamin D2 - An analog of calcitriol active form of Vit D that selectively inhibits PTH formation

Answer 37

Paricalcitol

Question 38

An active form of Vit D that selectively inhibits PTH formation - Uses: o topical treatment of psoriasi

Answer 38

Calcipotriol

Question 39

salmon calcitonin is most often selected for clinical use (not human calcitonin), why?

Answer 39

longer half-life and greater potency

Question 40

Selective estrogen receptor modulator (SERM) - prevent or delay bone loss in postmenopausal women Inhibit PTH - stimulated bone resorption

Answer 40

Raloxifene

Question 41

human monoclonal antibody binds to and prevents the action of RANKL -> inhibits osteoclast formation and activity

Answer 41

Denosumab

Question 42

Calcimimetic lowers PTH by activating the calcium-sensing receptor in the parathyroid gland

Answer 42

Cinacalcet

Question 43

short-chain organic polyphosphate compounds that reduce both the resorption and the formation of bone by an action on the basic hydroxyapatite crystal structure

Answer 43

Bisphosphonates

Question 44

Have direct effects on osteoclasts, including inhibition of farnesyl pyrophosphate

Answer 44

Bisphosphonate

Question 45

Morphine MOA

Answer 45

its mechanism will lead to reduction in transmitter release and pain

Question 46

Codeine vs. morphine

Answer 46

Codeine better absorbed orally Morphine iv or im

Question 47

Codeine is a weak opiod

Answer 47

can be used to supplement NSAIDs in alleviating mild inflammatory pain or arthritis

Question 48

Mode of administration of fentanyl

Answer 48

Sublingual or transdermally bcz its liphophilic

Question 49

partial m receptor agonist - an inhibitor of serotonin- norepinephrine reuptake from the neuronal synaptic cleft

Answer 49

Tramadol

Question 50

Sides effects of opiods

Answer 50

Respiratory depression Constipation Pupillary constriction Histamine release

Question 51

Uricostatic drugs , (xanthine oxidase inhibitor)

Answer 51

Allopurinol Febuxostat

Question 52

lower uric acid levels by inhibiting its synthesis a Uricostatic Drug (xanthine oxidase inhibitor)

Answer 52

Allopurinol

Question 53

a Uricostatic Drug (xanthine oxidase inhibitor) - a non-purine inhibitor of xanthine oxidase

Answer 53

Febuxostat

Question 54

alkaloid extracted from the autumn crocus - used to both prevent and relieve acute attacks

Answer 54

Colchicine

Question 55

Colchicine MOA

Answer 55

binds to tubulin preventing microtubule polymerization, effectively acting as a mitotic poison Preventing microtubule polymerization -> disrupts the mobility of granulocytes and inhibits their migration to the joint

Question 56

Drugs of choice to treat acute attacks of gout Contraindicated in patients with: o peptic ulcer disease

Answer 56

Indomethacin

Question 57

used to treat acute gout in patients that cannot use NSAIDs

Answer 57

Prednisone

Question 58

Uricosuric drug

Answer 58

Probencid Losartan

Question 59

Losartan MOA

Answer 59

Angiotensin II antagonist Inc ph dec risk of stones

Question 60

Uricolytic drug

Answer 60

Rasburicase

Question 61

Converted to allantoin

Answer 61

Rasburicase