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MSK > Pharma > Flashcards

Pharma Flashcards

1
Q

Used to treat RA & bowel diseases such as crohn’s

A

Sulfasalazine

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2
Q

Competitive inhibition of DHFR

A

Methotrexate

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3
Q

Inhibit AICAR transformylase —> inhibit purine synthesis

A

Methotrexate

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4
Q

Metabolized to mercaptopurine —> inhibit DNA
Has drug interaction w allopurinol

A

Azathioprine

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5
Q

Converted to teriflunomide -> inhibit DHOD -> inhibit pyrimidine this inhibiting RNA synthesis

A

Leflunomide

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6
Q

Leflunomide

A

Well absorbed orally
Long half life
Active metabolite goes enterohepatic circulation
Risk of hepatic failure

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7
Q

inhibit IL-2 & not cytotoxic

A

Cyclosporin A

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8
Q

Phosphoramide mustard which Alkylate DNA and inhibit dna , RNA cross linking

A

Cyclophosphamide

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9
Q

Inhibit JAK

A

Tofacitinib

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10
Q

Bind to TNF - a and inhibit it’s effects
Side effects; upper respiratory infection

A

Infliximab

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11
Q

Inhibit IL-1
Metal chelator in wilsons disease

A

D-pinicillamine

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12
Q

Anti-malaria and used in Sjögren’s syndrome

A

Chlorquine

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13
Q

Drugs that causes bone more suppression

A

Methotrexate
Azathioprine
Leflunomide
D-penicillamine

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14
Q

Drug that doesn’t cause Bone marrow suppression

A

Cyclosporin - A

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15
Q

Irreversible non selective cox inhibitor

A

Aspirin

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16
Q

St high doses causes hyperventilation and res alkalosis

A

Aspirin

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17
Q

What drug interact with aspirin to reduce the rate of absorption ?

A

Antacids

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18
Q

What drug interact with aspirin to increase the risk of bleeding

A

Heparin

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19
Q

What drug interact with aspirin to reduce urate excretion!

A

Probencid

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20
Q

What drug interact with aspirin to increase it half life ?

A

Naproxen

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21
Q

Reye disease is a side effect of which drug ?

A

Aspirin

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22
Q

Non competitive non selective reversible COX inhibitor

A

Paracetamol (acetaminophen)

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23
Q

Paracetamol pathway used for children

A

Conjugation with sulfate

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24
Q

Predominat pathway for paracetamol in adults

A

Conjugation with glucuronide

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25
Q

Competitive non selective reversible cox inhibitor
Indol derivative

A

Indomethacin

26
Q

Competitive non selective cox inhibitor
Propionic acid

A

Ibuprofen
Naproxen

27
Q

Competitive non selective cox inhibitor
Phenylacetic acid derivative

A

Diclofenac

28
Q

Selective cox 2 inhibitor
Dipyridinyl derivative

A

Etoricoxib

29
Q

Selective cox 2 inhibitor
Pyrazole derivative

A

Celecoxib

30
Q

Oral synthetic prostaglandin
Used to treat and prevent peptic ulcers

A

Misoprotosol

31
Q

Normalize the hypothalamic’thermostat’ altered by pg’s in the brain
Reduce fever by inhibiting PG synthesis

A

Antipyretic action

32
Q

Alleviate pain by removing hyperalgesic effects of PGs

A

Analgesic action

33
Q

Prevent thrombosis by reducing formation of platelet aggregating theomboxane A2

A

Aspirin

34
Q

Effect of inhibiting cox 2

A

Decrease the release of anti-aggregatory prostaglandin I2
But it does not affect Thromboxane bcz it lacks cox2

35
Q

PTH synthetic analog increases osteoblast proliferation, differentiation and activity
o for parenteral treatment of osteoporosis

A

Teriparatide

36
Q

1αHydroxyvitamin D2 , converted in the liver to 1,25dihyroxyvitamin D
active form of Vit D that selectively inhibits PTH formation

A

Doxercalciferol

37
Q

19nor1,25dihydroxyvitamin D2
- An analog of calcitriol
active form of Vit D that selectively inhibits PTH formation

A

Paricalcitol

38
Q

An active form of Vit D that selectively inhibits PTH formation - Uses:
o topical treatment of psoriasi

A

Calcipotriol

39
Q

salmon calcitonin is most often selected for clinical use (not human
calcitonin), why?

A

longer half-life and greater potency

40
Q

Selective estrogen receptor modulator (SERM)
- prevent or delay bone loss in postmenopausal women
Inhibit PTH - stimulated bone resorption

A

Raloxifene

41
Q

human monoclonal antibody
binds to and prevents the action of RANKL -> inhibits osteoclast
formation and activity

A

Denosumab

42
Q

Calcimimetic
lowers PTH by activating the calcium-sensing receptor in the
parathyroid gland

A

Cinacalcet

43
Q

short-chain organic polyphosphate compounds that reduce both the
resorption and the formation of bone by an action on the basic hydroxyapatite
crystal structure

A

Bisphosphonates

44
Q

Have direct effects on osteoclasts, including inhibition of farnesyl pyrophosphate

A

Bisphosphonate

45
Q

Morphine MOA

A

its mechanism will lead to reduction in transmitter release and pain

46
Q

Codeine vs. morphine

A

Codeine better absorbed orally
Morphine iv or im

47
Q

Codeine is a weak opiod

A

can be used to supplement NSAIDs in alleviating mild
inflammatory pain or arthritis

48
Q

Mode of administration of fentanyl

A

Sublingual or transdermally bcz its liphophilic

49
Q

partial m receptor agonist
- an inhibitor of serotonin- norepinephrine reuptake from the neuronal
synaptic cleft

A

Tramadol

50
Q

Sides effects of opiods

A

Respiratory depression
Constipation
Pupillary constriction
Histamine release

51
Q

Uricostatic drugs , (xanthine oxidase inhibitor)

A

Allopurinol
Febuxostat

52
Q

lower uric acid levels by inhibiting its synthesis
a Uricostatic Drug (xanthine oxidase inhibitor)

A

Allopurinol

53
Q

a Uricostatic Drug (xanthine oxidase inhibitor)
- a non-purine inhibitor of xanthine oxidase

A

Febuxostat

54
Q

alkaloid extracted from the autumn crocus
- used to both prevent and relieve acute attacks

A

Colchicine

55
Q

Colchicine MOA

A

binds to tubulin preventing microtubule polymerization, effectively
acting as a mitotic poison

Preventing microtubule polymerization -> disrupts the mobility of
granulocytes and inhibits their migration to the joint

56
Q

Drugs of choice to treat acute attacks of gout
Contraindicated in patients with: o peptic ulcer disease

A

Indomethacin

57
Q

used to treat acute gout in patients that cannot use NSAIDs

A

Prednisone

58
Q

Uricosuric drug

A

Probencid
Losartan

59
Q

Losartan MOA

A

Angiotensin II antagonist
Inc ph dec risk of stones

60
Q

Uricolytic drug

A

Rasburicase

61
Q

Converted to allantoin

A

Rasburicase

MSK (7 decks)

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