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MSK > Muscle biochem > Flashcards

Muscle biochem Flashcards

1
Q

Lots mitochondria
Short diameter
Aerobic
High oxidative capacity
Jogging

A

Slow twitch fibers

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2
Q

Immediate source of ATP

A

creatine phosphate

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3
Q

What is the substrate & product in adenylate kinase pathway ?

A

ADP > substrate
ATP > product

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4
Q

What happens when ATP binds to myosin ?

A

Detachment of actin & myosin

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5
Q

What causes fatigue?

A

Low ATP due to :
⬇️phosphocreatine
⬇️glycogen content
Limitation of FA oxidation
⬆️protons

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6
Q

During intense exercise , what inc & dec

A

Carb ⬆️
Fat ⬇️

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7
Q

What activate glycogen phosphorylase and glycogen phosphorylase kinase ?

A

AMP & calcium

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8
Q

What differs glycogen phosphorylase in muscle from liver ?

A

It contain allosteric binding site for AMP

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9
Q

What is Cory cycle ?

A

Allows the liver to produce glucose via utilization of extrahepatic lactate

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10
Q

Epinephrine pathway leads to what ?
EPI > cAMP > pka > GPK > ?

A

High activity of glycogen phosphorylase

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11
Q

Why does the muscle switch to FA consumption?

A

To conserve muscle glycogen

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12
Q

What activates muscle phosphorylase kinase & phosphoprotein phosphate we ?

A

Calcium

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13
Q

What does calcium activates ?

A

PDH & PKA

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14
Q

What inhibit PFK1 ?

A

Accumulating of citrate

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15
Q

Indirect way of the muscle to eliminate nitrogen ?

A

Glucose-alanine pathway

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16
Q

What enzyme is alloestrical activated by amp ?

A

Phosphorylase b

MSK (7 decks)

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