PHARMA Flashcards
the branch of medicine concerned with the uses, effects, and modes of
action of drugs.
Pharmacology
the Father of Pharmacology.
Paracelsus
BRANCHES: What the drug does to body
Pharmacodynamics
BRANCHES: What the body does to drug
Pharmacokinetics
BRANCHES: The study of the use of drugs
Pharmacotherapeutics
BRANCHES: Preparing suitable dosage forms
Pharmacy
BRANCHES: The study of drug dosage
Posology
BRANCHES: The study of nature, effects and detection of poisons
Toxicology
Refers to the quantity of drug administered at one time (ex: 500mg PARACETAMOL)
Dose
Refers to the amount of drug that should be given over time (ex: 500mg PARACETAMOL three times a day for 3 days)
Dosage
Dutch droog, meaning dry; are chemical substances that have an effect on living organisms.
Drugs
therapeutic drugs used in the treatment of diseases; prescribed by a physician
Medicines
are the scientific names based on the molecular structure of the drug.
Chemical Name
a commercial name granted by a naming authority for use in marketing a drug/device product in a particular jurisdiction.
Trade Names/Brand Names
means the name of a genus. This term is usually used to name a class or category of products or services. Common or general name assigned to the drug; Is the official or non-proprietary name for the drug.
Generic Name
What makes a branded drug expensive?
Inactive substance ( to taste and smell better)
Adds color to make it attractive
The company bought the name (each letter has a price).
DRUG CREATION: Name the 7 steps in creating a drug.
- Find a Target
- Compound hitting
- preclinical studies
- IND application approved
- Complete phase I, II, III
- NDA Approved
- Monitor the drug’s use
DRUG CREATION: The three targets that drugs affect
microorganisms
hormones
organ
DRUG CREATION: IND stands for
investigational new drug
DRUG CREATION: NDA stands for
New Drug Application
DRUG CREATION: Phase 1 of the clinical trials include…
less than 200 ind. (healthy). No Cancer, Hypertension, Asthma, Diabetes
DRUG CREATION: Phase 2 of the clinical trials include…
less than 200 ind. (with specific diseases)
DRUG CREATION: Phase 3 of the clinical trials include…
more than 200 ind. (w/ specific diseases)
DRUG INFO: A list of medical conditions or diseases for which the drug is meant to be used.
INDICATIONS
DRUG INFO: A description of the cellular changes that occur as a result of the drug.
Action
DRUG INFO: A list of conditions for which the drug should not be given.
Contraindication
DRUG INFO: A list of conditions or types of patients that warrant closer observation for a specific side effects when given the drug.
CAUTIONS
DRUG INFO: List of contraindications include…
hypersensitivity, pregnant, liver or kidney problems
DRUG INFO: list of possible unpleasant or dangerous secondary effects, other than the desired effects.
Side Effects and Adverse Reactions
DRUG INFO: A list of other drugs or food that may alter the effect of the drug and usually should not be given during the same course of therapy.
Interactions
DRUG INFO: Catapres is for _____
hypertension
DRUG INFO: immodium is for ______
diarrhea
DRUG INFO: Salbutamol causes _____
bronchodilation
Sources of Drug Information
- Drug Handbook
- Physician Desk Reference (PDR)
- Packet Insert
- Nursing Journal
- Medical Let
- MIMS (Monthly Index of Medical Specialties)
LAWS: The law says that all preparations called by the same drug name must be of uniform
strength, quality and purity
DRUG STANDARDS
LAWS: Required all drugs marketed to meet minimal standards of strength, purity and quality.
WILEY ACT
LAWS: Responsible for approval and removal of products on the market.
FDA
LAWS: “Warning” labels must be present on certain preparations, for example, “may cause drowsiness”, may cause “nervousness”, and “may be habit forming”.
Cosmetic Act
LAWS: distinguished between drugs that can be sold with or without prescription and those that should not be refilled without a new prescription, such as narcotics, hypnotics, or tranquilizer must be so labelled.
Durham-Humphrey Amendment
LAWS: tightened controls on drug safety, especially experimental drugs, and required that adverse reactions and contraindications must be labelled and included in the literature.
Kefauver-Harris Amendment
LAWS: This act, designed to remedy the escalating problem of drug abuse.
Controlled Substances Act
LAWS: This reform act shortened the time in which new drugs could be developed and marketed.
DRRA (Drug Regulation Reform Act)
LAWS: The regulation were changed to increase the approval rate of drugs used to treat AIDS and cancer.
DRA (Drug Relation Act)
LAWS: drug companies that plan to discontinue drugs must inform health professionals and clients at least 6 months before stopping drug production.
MODERNIZATION ACT
LAWS: Generally, nurses cannot prescribe or administer drugs without a health care provider’s order, but state laws vary.
NURSE PRACTICE ACT
LAWS: An act providing for a more responsive nursing profession.
RA 9173
OFFENSES: Negligence; giving the wrong drug or drug dose that results in the client’s death
MISFEASANCE
OFFENSES: Omission; omitting a drug dose that results in the client’s death
NONFEASANCE
OFFENSES: Giving the correct drug but by the wrong route that results in the client’s death.
MALFEASANCE
DRUG ACTION: is the breakdown of a tablet into smaller particles
Disintegration
DRUG ACTION: is the dissolving of the smaller particles in the GI fluid before absorption
Dissolution
DRUG ACTION: is the time it takes the drug to disintegrate and dissolve to become available for the body to absorb it.
Rate Limiting
DRUG ACTION: 2 GI Fluids that cause dissolution
HCl acid & saliva
DRUG ACTION: The three areas of the GI tract considered to be acidic
mouth, esophagus, stomach
DRUG ACTION: resist disintegration in the gastric acid of the stomach, so disintegration does not occur until the drug reaches the alkaline environment of the small intestine.
Enteric Coated Drugs
DRUG ACTION: T/F: Enteric-coated drugs should be crushed for faster absorption
FALSE
DRUG ACTION: AKA the first phase of drug action
Pharmaceutic Phase
DRUG ACTION: aka 2nd phase of drug action; the process of drug movement to achieve drug action.
Pharmacokinetics Phase
DRUG ACTION: the 4 phases of pharmacokinetics
absorption (bioavailability), distribution metabolism, excretion
PHASES OF PHARMACOKINETICS: is the movement of drug particles from GI tract to body fluids by passive absorption, active absorption, and pinocytosis.
ABSORPTION
PHASES OF PHARMACOKINETICS: this occurs mostly by diffusion; movement from higher concentrations to lower concentrations. No energy is required to move across the membranes.
Passive absorption
PHASES OF PHARMACOKINETICS: this required a carrier such as an enzyme or protein to move the drug across the concentration gradient.
Active absorption
PHASES OF PHARMACOKINETICS: a process by which the cells carry the drug across the membrane by engulfing the drug particles.
Pinocytosis
Name the factors that affect drug absorption
a. Ph Type
b. Drugs that are lipid soluble
c. Blood flow, pain, stress, hunger, fasting, food, and pH affect drug
absorption.
d. Poor circulation as a result of shock, vasoconstrictor drugs, or disease hampers absorption.
e. Drugs given intramuscularly
T/F: Absorption is fast since there is no Hydrochloric acid present.
TRUE
If the drug is best absorbed in an alkaline environment should you eat or not?
DO NOT EAT
If the drug is best absorbed in an acidic environment (stomach), should you eat or not?
EAT
T/F: Drugs that are lipid soluble (nonionized) are not absorbed faster than water-soluble (ionized drugs).
FALSE
The slowest route of drug administration
Intradermal (ID)
The fastest route of drug administration
Intravenous (IV) and Intramuscular (IM)
PHARMACOKINETICS: the proportion of a drug or other substance which enters the circulation when introduced into the body and so is able to have an active effect.
BIOAVAILABILITY
Factors that alter bioavailability
1.Drug form
2.Route of administration
3.GI mucosa and motility
4.Food and other drugs
5.Changes in liver metabolism
DISTRIBUTION: the second pharmacokinetic phase and is the process by which the drug
becomes available to body fluids and body tissues.
DISTRIBUTION
DISTRIBUTION: plays a major role in distribution.
BLOOD STREAM
DISTRIBUTION: Drugs that are greater than 89% bound to protein are known as _______
highly protein-bound drugs.
DISTRIBUTION: Drugs that are ______ bound to protein are moderately highly protein bound.
61%-89%
DISTRIBUTION: Drugs that are 30%-60% bound to protein are
moderately protein-bound.
DISTRIBUTION: Drugs that are ______ bound to protein are low protein–bound drugs.
> 30%
METABOLISM: this is the third pharmacokinetic phase
METABOLISM
METABOLISM: primary site of drug metabolism is in ______
the “Liver”.
METABOLISM: is the time it takes for one half of the drug concentration to be eliminated.
Half-life (t1/2)
EXCRETION: This is the fourth and final pharmacokinetic phase.
EXCRETION