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NEET PG > Pharma > Flashcards

Pharma Flashcards

1
Q

strongest acid/alkali
is always found
In

A

ionised form

Eg: heparin

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2
Q

Forced alkalisation done using

A

Na bicarb

Aceto zolami de

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3
Q

urine acidification done by

A

ascorbic acid Ammonium Chloride

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4
Q

Absorption -…… form

excretion …… form

A

nonionised

Ionised

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5
Q

Henderson hesselback equation

A

pka= ps+ log (Ionised A / unionised A )

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6
Q

PKA =pH H H equation

A

50%

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7
Q

P.glycoprotein inhibitors

A

VAQCINE
Nera pamil
amiodarone Cyclosporine Itraconazole Nifedipine erythromycin Quinidine

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8
Q

Most potent p glyco

inhibitor

A

Verapamil

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9
Q

Eg: ofa drug affected ey p-glycoprotein

A

digoxin

BA dec

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10
Q

P. glycoprotein induces

A

Rifampicin St. John’s wort
Phenytoin
carbamazepine

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11
Q

Bioequivalent drugs

A

BA diff <20%.

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12
Q

Rear for passive transport

A

lipid soluble

Non ionised

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13
Q

uptake of AA by brain

is a form of

A

facilitated

diffusion

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14
Q

heast canon method
of drug transport
with eg

A

Pinocytosis

insulin

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15
Q

any 4 orphan

drugs

A

Fomi pizole
Leothysonine
Digi band
Protamine sulfate

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16
Q

active form of

thyroxine? used in?

A

mynedema coma

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17
Q

essential drugs must be

A

affordable
available
single compound

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18
Q

Dang distr i b ution in

3 components

A

42=4+10+28

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19
Q

chloroquine digoxin TCA low/high vd

A

Large Vd

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20
Q

Avoid dialy sis in poison oning

of what kind of drugs

A

Large Vd
AVOID Dialysis
Amphetamine Verapamil OPC opioids Imipramine (TCA) D igoxin Diazepam

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21
Q

Eg: of adrug swith strong plasma

protein binding

A

Diazepam

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22
Q

Vd formula

A

total dose / Plasma concentration

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23
Q

Loading dose =

A

Vd x target plasma

concentration

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24
Q

T1/2=

A

0:693 x Vd /clearance

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25
Q

Clearance =

A

rate of elimination /plasma concentration

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26
Q

Maintenance dose

=

A

cLx plasma conc

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27
Q

Acidic drugs usually
bind
basic.

A

Albumin

x-1 acid glycoprotein

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28
Q

aI acid glycoprotein increased in

A

MI,

Burns Trauma

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29
Q

Aspirin displaces …… from protein

binding site

A

Tolbutamide

Warfarin

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30
Q

…… displaces

bilirubin i n

A

sulphonamide
c(I newborn
keen icterus

31
Q

G1 phase enzyme

A

L- asparaginese

32
Q

CDK4,6 inhibitors

A

Palbo ciclib
Abema ciclib
Ribociclib

33
Q

ADR an uses of

L- asparaginese

A

hemorrhagic pancreatitis hypecoagulation
ALL
E. coli

34
Q

Steroids

A
35
Q

steroids act on

which phase

A

S

36
Q

Tenoposide

Stop oside

A

Epipodophyllotoxin

37
Q

Tenoposide

Stop oside

A

Epipodophyllotoxin

38
Q

Topoi somerase I

inhibitor

A

Irinotecan
Topote can
G2

39
Q

Topoisomerase II inhibifor

A

Etoposide
Tenoposide
Antheacycline
antibiotics

40
Q

Dose limiting ttoxicity of Irinote can

A

Diarrhea

41
Q

drugs acting on M

phase

A

Vinca alkaloids
Taxanes
Ixabepilone Erbul in

42
Q

Estramustim

A

M. phase

Prostate cancer

43
Q

all anti biotic anticancer drugs are cytotoxic except

A

Bleomycin

44
Q

Permetrexed Trimetrered

A

Mesothelioma
Non small cell lung cancer
anti folate

45
Q

Pralatrexate

Ralti thaxate

A

1- cutaneous T- cell lymphoma
2. Mesothelioma
colOrectal ca

46
Q

antidote for anti folate

exept M+x

A

Vit B12+ Folic acid

47
Q

MOA MTX

A

MTX PG inbulents DH FR

48
Q

_ … increase M tx action

A

P. glycoprotein inhibitors

49
Q

DOC for choriocarcinoma

A

Mtx

50
Q

Mfx as DMARD dose

A

7.5 mg) week

51
Q

loco close long term Mtx used in

A

R.A.

52
Q

ADR MTX

A 
my elo suppression
Alopecia
GI toxicity
long term - hepato toxiatry
crystall ria
53
Q

Folinic Acid raikk overncome

all ADR of Mtx except

A

Neurotoxinty?

54
Q

-
…… lused as antidote fOr
pts with Mtx toxicity and kidney disease

A

GLUCAR BIDASE

55
Q

Purine antimet abolites

A 
6_Thio guanine
6-Mencaptopurine
Fludarabine
C ladribine
Pento statin
56
Q

DOC_hairy call leukemia

A

Gladri bine

57
Q

Pentostatin

A

adenosine deaminase
inhibitors
CLL

58
Q

active form of 6-MP

A

6- Thiosinic acid

59
Q

Leesh Nyhan synchome

A

def of HGPRT

60
Q

xanthine oxidase inhibitors

A

allopurinol

febunostat

61
Q

Pyramidine anti metabolites

A

Cytarabine
5-FU
Gemcitab ine
Capecitabine

62
Q

ADR cytarabine

A

Myelosuppression
Cerebellar ataxia
dysarthria

63
Q

leucomisole

A 
anti helmin this agent having immunostimulatory action
colorectal ca (along with 5-FU)
64
Q

5 Fu lencoverin interaction

A

L increases action of 5 FU

65
Q

Topical use of sFU

A

BCC keratosis

66
Q

hand foot synchome

A

vasospasmic action

of 5-FU

67
Q

DOC adenocarcinoma pancreas

A

G emcitab ine

68
Q

Radio sensitizer

A

Gemci +abine

69
Q

maximum risk of

hand foot syndrome

A

capecitabine

pro drUg S-FU

70
Q

Radiation recall reaction

seen in

A

Actinomycin D max

Dannorubicin Doxorubicin Mizoxandrone

71
Q

Cardio tomic anticancer antibiotics

A

Danno rubicin Doxo rubicin Mitoxantrone

72
Q

Mitoxantrone

used in

A

multi ple sclerosis

73
Q

uses of adriamycin

A 
ALL
AML
Breast ca
Osteosarco ma
MHL
HL
74
Q

antidote doxorubicin

A

Dexrazoxane

+ Alpha tocopherol

NEET PG (6 decks)

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