Pharma 10.1 Anti-arrhythmics

Question 1

What are the four classes of anti arrhythmic drugs.
What is their mechanism of action.
Give an example of each class

Answer 1

Class 1, Na Channel Blockers, lidocaine/ flecainide
Class 2, Beta Blockers, propranolol
Class 3, Prolong repolarisation, amiodarone
Class 4, Ca channel Blockers, verapamil

Question 2

What are the additional antiarrhythmic drugs, their MOA and examples

Answer 2

Cardiac glycoside, slow AV conduction, digoxin
Adenosine, slow AV conduction
Muscarinic Antagonist, speeds AV conduction, Atropine

Question 3

What would you use for sinus tachycardia?

Answer 3

Class 2, Beta blockers, propronolol

Class 4, calcium channel blockers, verapamil

Question 4

How do you treat AF/flutter

Answer 4

Class 1, Na channel blockers, flecainide
Class 2, Beta blockers, proponolol
Class 4, Calcium channel blockers, verapamil
Digoxin

Warfarin / NOACs to lower risk of stroke

Flecainide, 2 3 4 adenosine

Question 5

How do you treat AV block

Answer 5

Antimuscarinic (atropine)

Question 6

How do you treat ventricular tachycardia

Answer 6

Class 1, Na Channel Blockers, lidocaine
2, Beta blockers, propranolol
3, prolong repolarisation, amiodarone

Question 7

How do you treat WPW syndrome

Answer 7

Class 1, Na Channel blockers, flecainide

Question 8

How do you treat vagal bradycardia

Answer 8

Antimuscurinic (atropine)