Pharm Week 3 Flashcards
What is a known drug-herb interaction?
St. john’s wort induces drug-metabolizing enzymes and reduces the blood levels of many drugs
Which individual is at the highest risk for a drug-drug interaction?
a) a toddler who is prescribed two antibiotics for a serious infection
b) an adolescent who takes over the counter medications for menstrual cramping
c) an adult who takes eight prescription medications for a chronic condition
d) an older adult who takes two prescription meds and a dietary supplement for anxiety
C
what is the effect of grapefruit juice on the body with drugs ?
grapefruit juice can inhibit the metabolism of certain drugs which raises the blood levels
What is the timing for administering a drug on an empty stomach?
either 1 hour before or 2 hours after eating
Examples of nursing medication errors:
wrong rate, wrong time, wrong dose, wrong fluid, wrong drug, wrong route, wrong patient
What liver enzymes will be elevated when liver cells are injured ?
Aspartate aminotransferase and alanine aminotransferase
Who is most at risk for adverse drug reactions?
Older adults, very young, patients with severe illness, those who are taking multiple drugs
How many half lives does it take to reach plateau ?
4 half lives
How long does it take for the drug to leave the body after the discontinuation of the drug ?
4 half lives
What is an idiosyncratic effect?
an uncommon drug response resulting from a genetic predisposition
What is a paradoxical effect?
When an effect is the opposite of the intended drug response
What is a iatrogenic disease?
disease that occurs as the result of medical care or treatment ( a disease produced by drugs )
What is the carcinogenic effect?
The ability of certain medications and environmental chemicals to cause cancers
What is a teratogenic effect?
A drug- induced birth defect
Questions to ask when identifying adverse drug reactions
1)Did symptoms appear shortly after the drug was first used ?
2) Did symptoms abate when the drug was discontinued ?
3) Did symptoms reappear when the drug was reinstituted?
4) Is the illness itself sufficient enough to explain the event?
5) Are other drugs in the regimen sufficient to explain the event ?