Pharm Test #3 Flashcards
indications for use of adrenal agents
- widely used to suppress the immune system
- short-term use to relieve inflammation during acute stages of illness
do adrenal agents cure inflammatory disorders
NO
where are the adrenal glands located
flattened bodies that sit on top of each kidney
what two hormones do adrenal glands secrete
- cortisol
- aldosterone
this increases glucose and controls blood pressure
cortisol
causes kidneys to absorb sodium. CV is impacted if not working
aldosterone
3 types of corticosteroids
androgens, glucocorticoids, mineralocorticoids
what causes greatly reduced cortisol and aldosterone secretion
adrenal gland hypotension
what are the actions of the adrenocortical hormones
cause the release of glucose for energy
signs/symptoms of adrenal gland hypofunction
- hypoglycemia
- muscle weakness
- hypotension
- fatigue
- hyperkalcemia
signs of adrenal crisis
physiological exhaustion
hypotension
fluid shift
shock and even death
treatment of adrenal crisis
massive infusion of replacement steroids
constant monitoring and life support procedures
medications for glucocorticoids
dexamethasone
hydrocortisone - IV
methylprednisolone - IV
prednisone - oral ***know
what do glucocorticoids impact
the sugar
monitor blood glucose level
why be concerned if pt is on glucocorticoids long term
-make bones brittle
-monitor pt for fractures
-suppresses immune system- makes wounds hard to heal
-need to protect pt from infections
what are the actions of glucocortioids
initiate many complex reactions responsible for anti-inflammatory and immunosuppressive effects
why use glucocorticoids
- short term treatment of many inflammatory disorders
- to relieve discomfort
- give body a chance to heal from effects of inflammation
contraindications for glucocorticoids
- acute infection
-irritating to GI and can cause issues
cautions for glucocorticoid
acute peptic ulcer
indications for prednisone
replacement therapy in adrenal cortical insufficiency;
short term management of various inflammatory and allergic disorders,
hypercalcemia associated with cancer,
hematological disorders,
ulcerative colitis,
acute exacerbations of multple sclerosis
actions of prednisone
enters target cells and binds intracellular corticosteroid receptors, initiating many complex reactions responsible for anti-inflammatory and immunosuppressive effects
medication for mineralocorticoid
fludrocortisone
3 things to know about mineralocorticoid
- fludrocortisone
- take same time every day
- weigh daily bc pt gains a lot of weight and record
drug to drug interaction for mineralocorticoid
decrease effectiveness with salicylates, rifampin
adrenal gland hyperfunction
- cortisol is excessively secreted or
- aldosterone is excessively secreted
- can result in an adrenal gland problem, like a tumor
medication for adrenal gland hyperfunction
mifepristone — this can cause abortions
what is the actions of fludrocortisone
- increases sodium reabsorption in renal tubules and increases potassium and hydrogen excretion, leading to water and sodium retention
intended response or side effects about adrenocortical agents
-intended-reduce blood levels of glucocorticoids and aldosterone
-normal BG and BP
side effects: can lead to adrenal insufficiency
what do you teach patients about adrenocortical agents
-signs of adrenal insufficiency
-keep all blood work appointments
2 types of antibiotics
bacteriostatic
bactericidal
what do bacteriostatic antibiotics do
those substances that prevent growth of bacteria
what does bactericidal antibiotics do
kill bacteria directly
how do you select treatment of antibiotic
id the causative organism
-antibiotic is chosen that has been nown to be effective at treating invading organism
signs of infection
-fever
-lethargy
-increased wbc
-classic signs of inflammation
-look at cultures
how do bacteria become resistant to antibiotics
-adapt to environment
-longer antibiotic has been in use, greater the chance bacteria will develop into resistant strain
this is a group of powerful antibiotics used to treat serious infections caused by gram negative aerobic bacilli
aminoglycosides
common medication for aminoglycosides
gentamicin **know
what to know about gentamicin
ototoxic - hearing impairment or loss
harsh med - very toxic to kidneys
what type of antibioitic is aminoglycosides
bactericidal
pharmacokinetics of aminoglycosides
depend on kidney for excretion and are toxic to the kidneys
adverse effects of aminoglycosides
ototoxicity and nephrotoxicity *****
know
this new class of broad spectrum antibiotics effective against gram positive and gram negative bacteria
carbapenems
carbapenems medication to know
imipenem-cilastatin (Primaxin)
true or false
because of adverse effects of aminoglycosides, it is important to teach pt to restrict fluids and eat 6 small meals daily
false
try to drink lots of fluids to maintain nutrition even though nausea, vomiting and diarrhea may occur
indications of carbapenems
-treatment of serious infections caused by suseptible bacteria
what type of antibiotic is carbapenems
bactericidal
actions of carbapenems
inhibit cell membrane synthesis in susceptible bacteria leading to cell death
pharmacokinetics of carbapenems
excreted unchanged in urine - have an average half life of 1-4 hours
-this doesn’t get broken down in body
-okay to use for liver disease
adverse effects of carbapenems
pseydomembranous colitis, cdiff diarrhea, and nausea and vomiting can lead to serious dehydration and electrolyte imbalance
this is similar to penicillin in structure and activity
cephalosporins
common meds for cephalosporins
cephalexin (keflex)
ceftriaxone (rocephin)
what type of antibiotic is cephalosporins
bactericidal and bacteriostatic
what are the indications of cephalosporins
treatment of infections caused by susceptible bacteria
actions of cephalosporins
interfere with cell wall building ability of bacteria when they divide
pharmacokinetics of cephalosporins
-well absorbed from GI tract
-metabolized in liver, excreted in urine
contraindications of cephalosporins
-allergies to cephalosporins or penicillin ****
know
adverse side effects of cephalosporins
GI tract irritations
you are writing plan of care for patient receiving Cefaclor. What would be apporpriate nursing diagnosis for pt?
a. deficient fluid volume and imbalanced nutrition: less than body requirements, related to diarrhea
b. chronic pain RT GI, CNS effects of drug
c. monitor renal function test values
d. perform culture and sensitivity tests at the site of infection
a. deficient fluid volume and imbalanced nutrition: less than body requirements, related to diarrhea
this is relatively new synthetic class of antibiotics with broad spectrum of activity
fluoroquinolones
common meds for fluoroquinolones
ciprofloxacin (cipro)
levofloxacin (levaquin)
**know its broad spectrum antibiotic
actions of tetracyclines
inhibits protein synthesis insusceptible bacteria, preventing cell replication
pharmacokinetics of tetracyclines
- adequately absorbed from GI tract
- concentrated in liver, excreted unchanged in urine
adverse side effects of tetracyclines
-most GI but possible damange to teeth and bones
- causes teeth discoloration in children –> yellow/brown and is permanent
drug to drug interactions for tetracyclines
penicillin G, oral contraceptives
do you take tetracyclines with or without food
administer on empty stomach
pyridoxine = ?
B6
antituberculins contains
pathogens causing TB
what are two antituberculosis drugs
rifampin and isoniazid (INH)
if exposed to TB how long will be on isoniazid (INH)
6 months
what antituberculosis drug do you take with vitamin B6
isoniazid (INH)
first antibiotic introduced for clinical use
penicillin
which antibiotics do you use for severe infections caused by sensitive organisms and broad spectrums use
penicillin and penicillinase resisitant antibiotics
what are the actions of penicillin and penicillinase resistant antibiotics
interfere with the ability of susceptible bacteria to build their cell walls
these rapidly absorbed from GI tract, reaching peak levels in 1 hour. excreted unchanged in urine
penicillin and penicillinase resistant antibiotics
what are the contraindications of penicillin and penicillinase resistant antibiotics
allergies to penicillin or cephalosporins, renal disease
drug to drug interactions for penicillin and penicillinase resistant drugs
tetracyclines, parenteral aminoglycosides
these developed as semisynthetic antibiotics based on structure of common soil mold
tetracyclines
true or false
tetracyclines can lead to sun burns
true - pts on these drugs should stay out of the sun
what are the actions of antituberculins
act on DNA of bacteria leading to lack of growth and eventual bacterial death of TB
what are the pharmacokinetics of antituberculins
-absorbed well in GI tract
-metabolized in liver
how do you test for active TB
need gram of sputum of multiple days
true or false
chest xray is not a diagnosis of active TB
true. a chest x ray only shows if you were exposed. does not indicate TB is active or not
what are the adverse effects of TB drugs
hepatotoxicity
what are the drug to drug interactions for antituberculins
rifampin and INH can cause liver toxicity
contraindications of antituberculins
renal or hepatic failure
these vary in their effective ness against invading organisms
anti infectives
this kill the cell
bactericidal
this prevents reproduction of cell
bacteriostatic
effective against only a few microorganisms with a very specific metabolic pathway or enzyme
narrow spectrum of activity
“match the bug to the drug”
narrow spectrum of activity
useful in treating a wide variety of infections
broad spectrum of activity
what are examples of narrow spectrum of activity
PCN and amoxicillin
what are used to determine the type and extent of infection
culture and sensitivity tests
ability over time to adapt to an anti infective drug and produce cells that no longer affected by particular drug
natural or acquired resistance
these act on specific enzyme system or biological process, many microorganisms that do not act on this system are not affected by this particular drug
antiinfectives
how do you prevent resistance to medication
- limit the use of antimicrobial agents to the treatment of specific pathogens sensitive to drug being used
- make sure doses are high enough and duration of drug therapy is long enough
how is the ID of the infecting pathogen done
by culture
this determines which drugs are capable of controlling the particular microorganism
sensitivity test
what is a treatment of systemic infections
combination therapy
- some drugs are synergistic
ex; opioid can affect and tylenol
trying to prevent infection from occurring
give before surgery and then after to prevent infection
prophylaxis
who gets prophylaxis
- ppl traveling to area where malaria is endemic
- pts undergoing GI or genitourinary surgery
- pts with known cardiac valve disease, valve replacements, other invasive procedures
for dental work - how many hours before do CVD pts get the prophylaxis
72 hours
adverse reactions to antiinfective therapy
- kidney damage - highly toxic and renal failure
- GI toxicity
- Neurotoxicity
- Hypersensitivity Reactions - make sure pt isn’t allergic
- Superinfections - yeast & c.diff
- Ototoxcitiy
three antiinfective medications
- vancomycin
- gentamycin
- enoxaparin
what do you do for your pt who is on antiinfective therapy
monitor I & O, monitor any pt changes, get CBC
how long after pt receives new medications via IV will they have an allergic reaction
10 mins
thyroid gland produces two thyroid hormones using iodine found in diet
- tetraiodothyronine or levothyroxine (T4)
- triiodothyronine or liothyronine (T3)
what does the thyroid gland remove from the blood
iodine
what is T3 name
triiodothyronine
what is T4 name
tetraiodothyronine
four functions of thyroid hormones
- regulate the rate of metabolism
- affect heat prodcution and body temperature
- affect metabolism of carbohydrates, fats, and proteins
- regulate growth and development
this needs replacement of hormones
is underactivity
hypothyroidism
treatment to slow down
overactivity
hyperthyroidism
what would cause hypothyroidism
- surgeries and had to remove some or all of thyroid gland
- not enough iodine in the diet to produce needed level of thyroid hormone
signs/symptoms of hypothyroidism
- constipation
- decreased appetite/weight gain
- bradycardia, hypotension
- cold all time
- decreased HR/RR
- lack of energy
- increased sleeping
medication for replacement hormone - hypothyroidism
levothyroxine (synthetic salt of T4)
what do you teach a pt about levothyroxine about before administration - 4
- check BP and HR especially the first dose
- check dose/drug name carefully
- ensure drug is given two hours before meal***
- take same time every day
what do you teach pt about after administration of levothyroxine
- check BP and HR
- ask pt about any chest pain
most important thing about levothyroxine
take two hours before meal
dose starts _____ and then is ____ ____ until patient has reached _____ level
dose starts LOW and is SLOWLY INCREASED until pt has NORMAL levels
intended responses of levothyroxine
** know these
-body temp and level of activity are normal
-HR, BP and RR normal
-Pts body weight is maintained
-Pt is mentally alert
-BM pattern is normal
side effects of levothyroxine
-overdose of drug can cause hyperthyroidism
-increased activity of cardiac and nervous system
***** know this
what brings down calcium level
alendronate
if what is used with levothyroxine, it can cause gastric erosion
alendronate
this is excessive amounts of thyroid hormones are produced and released into ciruclation
hyperthyroidism
what is the cause of graves’ disease
hyperthyroidism
signs and symptoms of hyperthyroidism
increased body temp - too warm
tachycardia
palpitations
hypertension
flushing
intolerance to heat
amenorrhea
weight loss
sweating
what is a thyroid storm
increase fever
massive release
hypertension
abdominal pain
increase HR
this is medical emergency
what medications do you use for hyperthyroidism
propylthiouracil (PTU)
Methimazole
iodine solutions are used
actions of thioamides
prevent formation of thyroid hormone within thyroid cells, lowering serum level
what are antithyroid agents called
thioamides
iodine solutions
high dose of this block thyroid function
iodine solutions
when to use antithyroid agents
for hyperthyroidism
what is the pharmacokinetics of thioamides
absorbed from GI tract, concentrated in thyroid gland, some excretion detected in urine
pharmacokinetics of iodine solution
rapidly absorbed from gi tract, widely distributed throughout body fluids, excretion through urine
adverse effects of antithyroid agents
thioamides: thyroid suppression
iodine solutions: hypothyroidism
what do you do before you administer antithyroid meds
check pt’s liver function tests
what do you do after administering antithyroid meds
check WBC
check daily for yellowing of skin — could be liver dysfunction
what endocrine gland produces hormones in islets of langerhans
pancreas
this hormone is produced by beta cells of the islets of langerhans
insulin
this treats hyperglycemia
insulin
what is the physiology of glucose regulation
constant supply of glucose is needed for normal body function
this is rapid release insulin for type 1 diabetes
lispro
what does insulin do to K+
it pulls K+ and can cause hypocalcemia and dysrhythmia
actions of insulin
- released into ciruclation when levels of glucose around these cells rise
- stimulates glycogen synthesis, conversion of lipids into fat stored as adipose tissue and synthesis ofproteins from amino acids
- released after meals, causing blood glucose levels to fall, prevents blood glucose levels from becoming too high
- insulin causes blood glucose levels to decrease
this is released from alpha cells into islets of langerhans in repsonse to low blood glucose
glucagon
this casues immediate mobilization of glycogen stored in liver and raises blood glucose levels
glucagon
this breaks down glycogen into glucose
glycagon
secretion of ____ raises blood glucose levels to normal
glucagon
which diabetes can’t make insulin
type 1
what is type 1 diabetes called
insulin-dependent diabetes mellitus (IDDM)
this is rapid onset, seen in younger ppl
type 1 diabetes
connected in many cases to viral destruction of beta cells in pancreas
type 1 diabetes
is type 1 diabetes seen in
a. children and young adults
b. older adults, elderly
A. children and young adults
beta cells no longer make or secrete insulin. needs insulin replacement
type 1 diabetes
by product of using fat to make ATP
ketoacids
what is type 2 diabetes called
non insulin dependent diabetes mellitus (NIDDM)
in what age group does type 2 diabetes occur
older adults
this is slow and progressive onset
type 2 diabetes
what are the big risk factors for type 2 diabetes
obesity
sedentary lifestyle
what insulin do you use for type 2 diabetes
regular, NPH (intermediate acting)
increased blood sugar
hyperglycemia
sugar spilled into urine
glycosuria
increased hunger
polyphagia
increased thirst
polydipsia
fat breakdown
lipolysis
ketones cannot be removed effectively
ketosis
liver cannot remove all the waste products
acidosis
signs of hyperglycemia
fatigue
lethargy
weight loss
glycosuria
polyphagia
polydipsia
polyuria
itchy skin
what do you check before administering insulin
test pt’s blood glucose level
check vial for color and clarity
breakdown of fat and glycogen to release glucose
pancreas releases glucagon to increase glucose and somatostatin
hypoglycemia
signs/symptoms of hypoglycemia
headache
blurred vision
drowsiness
weakness
tachycardia
rapid shallow breaths
hunger
diaphoresis
cool, clammy skin
patient teaching for hypoglycemia
**know
teach pts how to self admin insulin
teach pts about proper storage insulin
check inject site daily for signs of infection
dont skip or delay meals
always carry a carb source
keep to schedule of insulin and meals
what do all sulfonylureas can cause
hypoglycemia
these bind to potassium channels on pancreatic beta cells, may improve insulin binding to insulin receptors and increase number of insulin receptors
sulfonylureas
you must wait 48 hours before or after contrast dye to take this medication
biguanide - metformin
what to teach pt about metformin
- causes gi issues
- take same time every day
- can cause hyperglycemia
- cannot have contrast dye - can cause severe kidney damage
treatment for COPD - what to do
-reduce environmental exposure to irritants
-decrease effects of inflammation on airway lining
manifestations of COPD
- obstructive condition
- air is trapped in lower respiratory tract
- alveoli degenerate and fuse together
- exchange of gases is greatly impaired (can have higher CO2 levels in blood)
these are used to facilitate respiration by dilating airways
bronchodilators/antiasthmatics
these are rarely prescribed anymore due to several serious side effects (neurologic)
xanthines
what type of medication is xanthine
brochodilator/antiasthmatics
this medication stays in blood. can cause toxicity if levels get too high
theophylline
direct effect on the smooth muscles of respiratory tract, both in bronchi and in blood vessels
xanthines
adverse reactions for xanthines
-related to theophylline levels in blood
-gi upset, nausea, irritability, and tachycardia
this mimics effects of sympathetic nervous system: dilation of bronchi with increased rate and depth of respiration
sympathomimetics
these are bronchodilators
sympathomimetics
this is used as an emergency drug for rescue
albuterol
what sympathomimetic only lasts for 20 mins.
epinephrine (epi pen)
what do you always do when using bronchodilators
check HR before and after admin
two drugs that are bronchodilators
albuterol and epinephrine (epiPen)
nursing considerations for sympathomimetics
- cigarette use
- patient teaching how to use inhaler correctly and what drug is maintenance and which is rescue
which drug is for maintenance
anticholinergics
which drug is for rescue
albuterol
what position do you put pt in when using inhaler or albuterol
high fowlers or semi fowlers
pts who cannot tolerate sympathetic effects of sympathomimetic might respond to which type of drugs
anticholinergics
two anticholinergics used to lower respiratory tract
- ipratropium
- tiotropium *** know
are anticholinergics rescue or maintenance drugs
maintenance
adverse effects of anticholinergics
blurred vision
dry mouth
urinary retention
constipation
dizziness
palpitations
nursing considerations for anticholinergics
assess:
1. acute bronchospasm, bladder neck obstruction or prostatic hypertrophy, orientation, effect and reflexes
2. pulse and b/p, respirations, adventitious sounds and urinary output
are leukotriene receptor antagonists rescue or maintenance drugs
maintenance
these act more specifically at the site of problem associated with asthma
leukotriene receptor antagonists
drug to drug interactions for leukotriene receptor antagonists
propranolol and warfarin
** know
nursing considerations for leukotriene receptor antagonists
assess:
acute bronchospasm or asthmatic attack
impaired renal hepatic function
works at the cellular level to inhibit the release of histamine
mast cell stabilizers
treatment of chronic bronchial asthma
indications of mast cell stabilizers
used for several inflammatory conditions
corticosteroids
common examples of corticosteroids
prednisone
betamethasone
dexamethasone
hydrocortisone
do you stop taking corticosteroids abruptly
no.
contraindications for corticosteroids
things to consider:
risk of infection - due to anti inflammatory and immunosupressive effects
risk of hyperglcemia - due to glucose elevating effects of steroids
peptic ulcer - due to ulcer association with use of steroids
this is a cough supressant
antitussives
decrease blo0d flow to upper respiratory tract and decrease over productive of secretions
decongestants
increases secretions and narrows airways
antihistamines
increase productive cough to clear airways
expectorants
thins mucus to clear airway
mucolytics
what is something you do when you give drugs that act on upper respiratory tract
check heart rate
what medications are antitussives
benzonatate (tessalon)
codeine
dextromethorphan
decongestant medications
oxymetazoline - put up nose. too much causes overproduction
phenylephrine
fluticasone - inhaler
antihistamine medication
diphenhydramine - in Tylenol PM
hydroxyzine - combines with narcotic
promethazine - used for nausea
actions of antitussives
act directly on medullary cough center of the brain to depress the cough relfex
increase or liquefy respiratory secretions to aid clearing of airways
mucolytics
-this medication smells like rotten eggs
-goes in inhaler
acetylcysteine
with this medication - if pt has tylenol allergy, give orally
acetylcysteine
what medication is a expectorant
guaifenesin
contraindications of antitussives
-pts who need to cough to maintain airway
-head injury or impaired CNS - dont always have ability to cough
adverse affects of antitussives
drying effect on mucous membranes
nursing considerations for antitussives
assess:
temperature, respirations, adventitious sounds
this decrease the overproduction of secretions by causing local vasoconstriction to the upper respiratory tract
topical nasal decongestants
topical nasal decongestants medication
oxymetazoline
how long do you wait before and after to drink/eat when taking antitussives
15-20 mins
adverse affects of topical nasal decongestants
local stinging and burning
rebound congestion
sympathomimetic effects
are topical nasal decongestants short for term or long term use
short term use
waht are the nursing considerations for topical nasal decongestant
assess
-glaucoma, diabetes, hypertension
-respirations and adventitious lung sounds
these decrease nasal congestion r elated to common cold, sinusitis and allergic rhinitis
oral decongestants
oral decongestant medication
pseudoephedrine
this elevates BP - watch for hypertension
oral decongestants
contraindications of oral decongestants
any condition that might be exacerbated by sympathetic activity
adverse effects of oral decongestants
rebound congestion
nursing considerations for oral decongestants
assess:
-hypertension
-hyperthyroidism, diabetes mellitus, prostate enlargement
-orientation, reflexes and affect
-extrapyramidal effects
cautions for antihistamines
renal or hepatic impairment
nursing considerations for antihistamines
skin: color, texture change
increase productive cough to clear the airways. they liquify lower respiratory tract secretions, reducing the viscosity of these secretions and making it easier for the pt to cough up
expectorants
expectorant medication
guaifenesin
adverse effects of expectorants
gi symptoms
headache
dizziness
prolonged use may result in masking a serious underlying disorder
increase or liquefy respiratory secretions to aid the clearing of the airways in high risk respiratory pts who are coughing up thick, tenacious secretions
mucolytics
adverse reaction of topical nasal steroids
- hyperglycemic
- delays wound healing
- risk for infection
- brittle bones
mucolytics medication
acetylcysteine
these work to break down mucous in order to aid the high risk respiratory pt in coughing up thick, tenacious secretions
mucolytics
what are the indications of mucolytics
-pts who have difficulty coughing up secretions
-pts who develop atelectasis
-pts undergoing diagnostic bronchoscopy
-postoperative pts
-pts with tracheostomies
pharmacokinetics of mucolytics
nebulization or direct instillation into trachea
what is important to know about rifampin **
it turns you orange, is rough on liver, rough on kidneys.
important to drink lots of water
waht is concern if on tetracycline
teeth staining
which antibiotic causes otoxicity
gentamicin
when taking these meds you want to stay out of the sun
tetracycline and doxycycline
what drug causes gastric erosion. you need to drink full glass of water when you take this medication
alendronate
do antibiotics treat viral infections
no
do you stop taking antibioitics if you start feeling better
no
when would you use glucagon
for hypoglycemia - can take IM, IV, subc
what does epinephrine do
elevate HR and is a bronchodilator
what is the first line treatment medciation
albuterol
are steroids the first or second line of treatment
second line
waht are the side effects of antibiotics
Common side effects of antibiotics can include rash, dizziness, nausea, diarrhea, or yeast infections. More serious side effects include Clostridioides difficile infection (also called C. difficile or C. diff),
know metformin, codeine
what type of drug is tropeium
anticholinergic
**know lispro