Pharm Test #3 Flashcards
indications for use of adrenal agents
- widely used to suppress the immune system
- short-term use to relieve inflammation during acute stages of illness
do adrenal agents cure inflammatory disorders
NO
where are the adrenal glands located
flattened bodies that sit on top of each kidney
what two hormones do adrenal glands secrete
- cortisol
- aldosterone
this increases glucose and controls blood pressure
cortisol
causes kidneys to absorb sodium. CV is impacted if not working
aldosterone
3 types of corticosteroids
androgens, glucocorticoids, mineralocorticoids
what causes greatly reduced cortisol and aldosterone secretion
adrenal gland hypotension
what are the actions of the adrenocortical hormones
cause the release of glucose for energy
signs/symptoms of adrenal gland hypofunction
- hypoglycemia
- muscle weakness
- hypotension
- fatigue
- hyperkalcemia
signs of adrenal crisis
physiological exhaustion
hypotension
fluid shift
shock and even death
treatment of adrenal crisis
massive infusion of replacement steroids
constant monitoring and life support procedures
medications for glucocorticoids
dexamethasone
hydrocortisone - IV
methylprednisolone - IV
prednisone - oral ***know
what do glucocorticoids impact
the sugar
monitor blood glucose level
why be concerned if pt is on glucocorticoids long term
-make bones brittle
-monitor pt for fractures
-suppresses immune system- makes wounds hard to heal
-need to protect pt from infections
what are the actions of glucocortioids
initiate many complex reactions responsible for anti-inflammatory and immunosuppressive effects
why use glucocorticoids
- short term treatment of many inflammatory disorders
- to relieve discomfort
- give body a chance to heal from effects of inflammation
contraindications for glucocorticoids
- acute infection
-irritating to GI and can cause issues
cautions for glucocorticoid
acute peptic ulcer
indications for prednisone
replacement therapy in adrenal cortical insufficiency;
short term management of various inflammatory and allergic disorders,
hypercalcemia associated with cancer,
hematological disorders,
ulcerative colitis,
acute exacerbations of multple sclerosis
actions of prednisone
enters target cells and binds intracellular corticosteroid receptors, initiating many complex reactions responsible for anti-inflammatory and immunosuppressive effects
medication for mineralocorticoid
fludrocortisone
3 things to know about mineralocorticoid
- fludrocortisone
- take same time every day
- weigh daily bc pt gains a lot of weight and record
drug to drug interaction for mineralocorticoid
decrease effectiveness with salicylates, rifampin