Pharm Test 2

Question 1

Pharmacodynamics

Answer 1

What drug does to body (therapeutic effect)

Question 2

Agonist

Answer 2

Perfect fit “Key in lock”

Question 3

Partial Agonist

Answer 3

Partial fit, partial response

Question 4

Antagonist

Answer 4

Blocks the site and prevents normal response

Question 5

Pharmacokinetics

Answer 5

What body does to drug (absorbed, metabolized, eliminated)

Question 6

Where are drugs metabolized?

Answer 6

Liver

Question 7

Where are drugs excreted?

Answer 7

Kidney

Question 8

What is a prodrug

Answer 8

Drug must be converted in liver to be effective

Question 9

Steady state

Answer 9

Amount of drug absorbed is amount excreted

Question 10

Peak

Answer 10

Highest blood concentration of drug

Question 11

Trough

Answer 11

Lowest blood concentration

Question 12

Toxicity

Answer 12

Peak level is too high

Question 13

Therapeautic Index

Answer 13

Ratio of effective dose to toxic dose

Question 14

Half life

Answer 14

Time it takes for 1/2 of original dose to be removed from body

Question 15

Bioavailability

Answer 15

% of drug that reaches systemic circulation

Question 16

Which drug has highest bioavailability?

Answer 16

IV drugs

Question 17

Which drug has lowest bioavailability?

Answer 17

PO drugs

Question 18

First pass effect

Answer 18

What occurs when concentration of a drug is greatly reduced during absorption process

Question 19

Drug metabolism factors

Answer 19

Condition of liver, health of patient, polypharmacy, age, gender, diet, environment

Question 20

Albumin

Answer 20

protein in blood that binds to “protein bound” drugs

Question 21

Albumin is the protein that prevents…

Answer 21

Edema

Question 22

Idiosyncratic reaction

Answer 22

Unexpected, usually mild but can be severe

Question 23

Allergic reaction

Answer 23

Uticaria

Question 24

Pregnancy Drug Risk

Category A

Answer 24

No risk to fetus

Question 25

Category X

Answer 25

Fetal abnormalities, drugs should NOT be used in pregnant women

Question 26

1st trimester

Answer 26

Greatest risk for developmental abnormalities

Question 27

Last trimester

Answer 27

Drug transfer to fetus is most likely

Question 28

Med compliance is an issue in 40%

Answer 28

Elderly

Question 29

Geriatrics are on 10+ meds a day

Answer 29

Increased likelyhood of adverse effects and toxicity

Question 30

Drug polymorphism

Answer 30

Effects of patients age, gender, size, body composition, genetics, and culture on drug responses

Question 31

Controlled labeling

Answer 31

All narcotics have FDA control number

Question 32

Schedule 1

Answer 32

Highest abuse potential, not prescribed in the US

Question 33

Drug Recall Class 1

Answer 33

Most serious: use of drug carries serious adverse health effects or death

Question 34

Class II

Answer 34

Less severe, use of drug can result in temporary/ reversible health effects

Question 35

Class III

Answer 35

Least severe: use of drug not likely to result in any significant health problems

Question 36

Pre clinical trial done on...

Answer 36

Tissue

Question 37

Clinical trial done on...

Answer 37

Humans with control / placebo groups

Question 38

What must participants do?

Answer 38

Informed consent

Question 39

What happens before continuing each clinical trial phase?

Answer 39

FDA must receive and approve before moving on

Question 40

Drug diversion

Answer 40

Taking/ Withholding drug from a patient

Question 41

Schedule 2

Answer 41

High abuse risk, written RX only, no refills

Question 42

Schedule 3 & 4

Answer 42

Written oral RX with expiration of 6 mo.

Question 43

Schedule 5

Answer 43

Low abuse potential, OTC

Question 44

IM injection

Answer 44

90 degrees

Question 45

Subcut injection

Answer 45

45 degrees

Question 46

Intradermal

Answer 46

15 degrees