pharm review Flashcards
1
Q
which local anesthetic useful in labor?
A
bupivicaine [amide]
2
Q
What is succinylcholine?
A
- binds postsynatpic nAChRs
phase 1: depolarizes
phase 2: changes conformation = desensitized to Ach
–> membrane repolarized but not Ach or succinylcholine can bind so reamins flaccid - ach ultimately overcomes phase 2 block
–> can lead to hyperkalemia
3
Q
Which non-depolarizing nAchR is shortest duration of action?
A
mivacurium
4
Q
What is action of sugammadex?
A
- direct antagonist to rocuronium [a non-depolarzing nAChr antagonist]
5
Q
Which non-depolarizng nAchR has a long duration of action?
A
pancuronium
6
Q
What drug do you give as diagnostic test for myasthenia gravis?
A
edrophonium b/c very short acting
7
Q
Which competitive AcHE inhibitor crosses the BBB? importance?
A
donepezil, can treat alzheimers and dementia
8
Q
What 3 AchE inhibitors can cross the BBB?
A
- donepezil
- galantamine
- rivastigmine
