Pharm Quiz 2 - instructor review

Question 1

alpha 2 agonist - used to treat

Answer 1

HTN (clonidine) (alpha 2 causes some vasodilation)

PTSD

Question 2

parkinson’s cause and treatment

Answer 2

loss of dopamine-producing neurons in brain causing unopposed ACh activity

treat with anticholinergic med and dopa supplementation

Question 3

ALZ treatment

Answer 3

AChEI to increase ACh activity, which enhances memory

Question 4

treatment for spastic bladder

Answer 4

anticholinergic

alpha 1 agonist - relaxes smooth muscle and constricts sphincter

Question 5

anticonvulsants work by

Answer 5

slowing Na+ movement through channels

Question 6

serotonin syndrome s/s

Answer 6

HTN, hyperreflexia, tremor, tachycardia –» seizures, hyperpyrexia

Question 7

SSRI withdrawal

Answer 7

flu-like symptoms

Question 8

common AEs antidepressants

Answer 8

weight gain, loss of libido

Question 9

with a first gen antipsychotic watch for (4)

Answer 9

1. Movement issues: akathesia, tardive dyskinesia, NMS
2. Cardiac: prolonged QT,
3. Liver function
4. Metabolic syndrome

Question 10

possible AEs of stimulants for ADHD

Answer 10

anorexia –> weight loss, change in sleep pattern, EKG changes/arrhythmias

Question 11

if you get a high TSH in a screen

Answer 11

confirm with free T4-should be low, this will confirm hypothyroidism

Question 12

advantages of metformin for DMII starting treatment

Answer 12

cheap, low risk of HoGly, lowers lipids, weight neutral

Question 13

when would you choose an SU for DMII?

Answer 13

renal disease-can’t use metformin or DPP4
poor control with metformin alone
cheap
lean, new Dx who make insulin

Question 14

stop these DMII meds if creatinine hits 1.5

Answer 14

metformin

DPP4

Question 15

SGLT2 DMII treatment-action and AE

Answer 15

causes kidney to dump glucose into urine
good for weight loss, lowest mortality esp cardiac
AE: UTI

Question 16

when picking oral hypoglycemic, consider (3)

Answer 16

renal function
cost
patient willingness, adherence

Question 17

pt with anxiety and insomnia, use

Answer 17

a sedating SSRI (paxil, prozac)

Question 18

2nd gen antipsychotic benefit

Answer 18

treats negative symptoms as well as positive

Question 19

muscarinic antagonists may offer same benefit as

Answer 19

beta 2 agonists

Question 20

norepinephrine causes release of

Answer 20

renin

Question 21

anticoagulants in pregnancy

Answer 21

heparin- yes

warfarin - no

Question 22

off switch of coagulation cascade

Answer 22

antithrombin III-protease that inhibits thrombin