Pharm Quiz 2 Content Flashcards
Process of Drug movement through the body
Absorption
Distribution
Metabolism(Liver)
Excretion(Kidneys)
Absorption
Movement of administration site into the blood
Factors affecting Absorption
Dissolution rate
Surface Area
Blood Flow
Lipid Solubility
pH
Route
Routes of administration
GI- Oral
Parenteral- IV, subQ, IM
Barriers of absorption fro PO administration
Absorption pattern?
Epithelial lining
Capillary wall
- Slow and varies
Barriers of absorption for IV administration
Absorption pattern?
None
Instant and complete
absorption pattern for IM and subQ
Water solubility and blood flow
when is parenteral administration preferred?
- Emergencies
- Tight Control needed
- GI incompatibility
- Drug cannot cross membranes
- Long action preparation needed
- Pt unwilling/unable to take oral meds
Distribution
Movement of drug throughout the body
Distribution process
Blood flow to tissue
Drug’s ability to enter cell
Ability to leave vasc. system
Drug Metabolism
Drug alteration to a more water soluble form that can be excreted
Factors in drug metabolism
Age
First pass effect
Nutritional Status
CompetitionE
Excretion
Removal of drugs
How can drugs leave the body? (5)
Bile
Waste
Sweat/Saliva
Breast milk
Expired air
Two important levels of Drug Response:
- Minimum effective concentration (MEC)
- Toxic
