Pharm Of Renal Infections Flashcards
Cystitis first line
Nitrofurantoin
Trimethoprim-sulfamethoxazole (TMP-SMX)
Fosfomycin
Cystitis second line
Oral beta lactate (amoxicillin, cefpodoxime, cefdinir, defadroxil)
Cystitis third line
Fluoros (cipofloxacin, levofloxacin, oflaxacin)
Which drug contraindicated in flu-6-phosphate dehydrogenase deficiency?
Nitrofurantoin
Don’t take fosfo or nitro when?
If there is suspicion for early pyelonephritis
Oral beta lactams or fluoros more effective?
Fluoros
They’re third line though d/t more adverse effects
Why moxifloxacin not recommended?
It attains lower levels than other fluoros
Fluoros adverse effects
*tendinitis and tendon rupture
Peripheral neuropathy
CNS effects
Don’t use what drugs to empirically treat uncomplicated cystitis
Ampicillin and amoxicillin
Can illicit resistance this way
Last line of defense drug for uncomplicated cystitis
Ertapenem
Pyelonephritis drugs
Fluros (ciprofloxacin, levofloxacin) + broad spectrum antibiotic( gentamicin, tobramycin)
TMP-SMX, oral beta lactam (aztreonam)
Complicated UTI treatment
Cystitis- ciproflaxacin or levofloxacin
Pyelonephritis (mild)- ceftriaxone, ciprofloxacin, levofloxacin, or axtreonam
Pyelonephritis (severe)- beta lactam +beta lactamase inhibitors or a carbapanem
Beta-lactamase inhibitors
Tazobactam
Avibactam
Carbapenems for complicated pyelonephritis
Imipenem
Doripenem
Meropenem
Ertapenem
Complicated pyelonephritis first line B-lactams
Piperacillin
Ceftazidime
Cefepime
Ceftolozane
