Pharm (not in Sketchy)

Question 1

Imiquimod

Answer 1

Im-mune mod-ulator:

• Activates TLRs –> upregulates NF-kB
• Antiproliferative (apoptosis, anti-angiogenic), treats skin things (e.g. cancer)

Question 2

Metolazone

Answer 2

Thiazide diuretic

Question 3

Ledipasvir

Answer 3

Used to tx HCV: NC5A inhibitor (otherwise crucial for viral replication and assembly)

Question 4

Sofosbuvir

Answer 4

Used to tx HCV: RNA dependent RNA polymerase inhibitor

Question 5

Bumetanide

Answer 5

Loop diuretic

Question 6

Iron chelating agents

Answer 6

Deferoxamine, deferasirox, deferiprone

- Useful in patients requiring frequent blood transfusions

Question 7

Sirolimus (MoA)

Answer 7

Binds to immunophilin FKBP → inhibition of mTOR = inhibits IL-2 pathway = inhibition of lymphocyte proliferation

Question 8

Sevelamer

Answer 8

non-absorbable anion-exchange resin - binds phosphorus and prevents absorption - useful in CKD

Question 9

Fidaxomicin mechanism

Answer 9

Inhibits sigma subunit of RNA polymerase

Question 10

What would you use to treat ascites in patient with cirrhosis

Answer 10

Spironolactone (In addition to the thyroid, the TSH receptor antigen is present on fibroblasts, adipocytes, and other tissues)

Question 11

Norepinephrine-releasing agents

Answer 11

Phentermine, diethylpropion, benzphetamine

• Indication: weight loss
• Contraindication: vasculopaths

Question 12

Meds you would use to treat BPH and HTN at the same time

Answer 12

Doxazosin, prazosin, terazosin (the others e.g. tamsulosin are selective alpha-1A blockers meaning they have less of an effect on HTN)

Question 13

Mechanism of resistance to TNF-a Ab in Crohn’s

Answer 13

Infliximab, Adalimumab can induce host anti-drug-antibodies

Question 14

Competitive testosterone receptor inhibitors

Answer 14

Aka “anti-androgens” Flutamide, bicalutamide, cyproterone

- Indication = prostate cancer obviously