Pharm Movement Disorders, Kinder II

Question 1

types of MAOIs

Answer 1

MAO A metabolizes NE serotinin and dopamine

MAO B metabolizes dopamine selectively

Question 2

MOA Rasagiline

Answer 2

irreversible inhibitor of MAO-B

Question 3

use of rasagiline

Answer 3

neuro protective agent and early symptomatic Tx parkinsons

Question 4

DDI levodopa and nonselective MAOI

Answer 4

leads to HTN crisis from accumulation NE

Question 5

what other drugs not used with MAOI

Answer 5

meperidine
tramadol
methadone
propoxyphene
cyclobenzaprine
OTC cold preparations

Question 6

3- O methyldopa competes with what

Answer 6

levodopa for active carrier mech that transport across intestine and bbb

Question 7

MOA entacapone

Answer 7

prolong action levodopa by diminishing peripheral metabolism

Question 8

use of entacapone

Answer 8

patients wtih response fluctuations

Question 9

entacapone effects

Answer 9

peripheral only, not central effects

Question 10

adverse effects catechol o methyltransferase inhbiitors

Answer 10

increased levodopa exposures
diarrhea, abdominal pain, orthostatic hypotension, sleep disturbances
orange urine!!!!!!!!!

Question 11

Amantadine

Answer 11

antiviral agent with weat anit parkinism properties

Question 12

what parkinson drug can cause lived reticularis skin condition

Answer 12

amantadine

Question 13

CI amantadine

Answer 13

Hx of seizures or heart failure

Question 14

MOA benztropine

Answer 14

mAChR antagonist

Question 15

use of benztropine

Answer 15

may improve tremor and rigidity in parkinsim

little effect on bradykinseia

Question 16

adverse effects benztropine

Answer 16

peripheral antimuscarinic effects like sedation, mental confusion constipation urinary retention and blurred vision

Question 17

most effective Symptomatic Tx for motor disturbances in parkinsons

Answer 17

carbidopa-levadopa

no dopaine agonists

Question 18

severe parkinson and long term complications of levodopa wtich to what theapy

Answer 18

COMT inhibitor or rasagiline

Question 19

what adrenergic R in essential tremor

Answer 19

B1 so respond to propanolol and metoprolol

Question 20

Symptomatic tremors controlled by

Answer 20

antiepileptic drugs like primidone or anticonvulsant topiramate

Question 21

what drugs are helpful in huntingtons

Answer 21

those that deplete dopamine: reserpine and tetrabenzine

dopamine R blockers: olanzapine, phenothiazines, haloperidol!!

Question 22

Tx tics

Answer 22

antipsychotis: tetrabenazine, haloperidol
alpha agonists: clonidine guanfacine
botulinum toxin

Question 23

Tx restless leg syndrome

Answer 23

correct Fe deficiency
dopamine agonists: levodopa, diazepam etc
non-ergot dopamine agonists: pramipexole

Question 24

1st line therapy in patients with daily restless leg syndrome

Answer 24

non-ergot dopamine agonists like pramipexole

Question 25

Tx wilsons disease

Answer 25

penicillamine | potassium disulfide

Question 26

Sx wilsons

Answer 26

``` tremor choreiform movements rigidity hypokinesia dysarthria dysphagia ```