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Pharm II > Pharm meds 1st half > Flashcards

Pharm meds 1st half Flashcards

1
Q

Meperidine

A

Opioid - MU and DELTA agonist - Exhaust all options first Acute dosing - for Shivers/Rigors Strong Hepatic metabolism - Renally cleared Metabolized into NORmeperidine NEG inotropic effects on heart CI - MAOI - severe withdrawals Anticholinergic effects - T-card and Mydriasis

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2
Q

Ibuprofen

A

NSAIDs - Vitamin-M Highly protein bound Low GI risk - Mod to High CV risk

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3
Q

Ketorolac tromethamine

A

NSAIDs - not for PEDS May decrease opioid need 25-50% IV - Mod-severe pain less than 5D and PO continue less than 5D Black box warning - Bleed risk (IV dose 15mg max) (IM dose 30mg max)

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4
Q

Aspirin

A

NSAIDs - irrev COX 1 and 2 inhibitor lasting 7-10D

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5
Q

Diazepam

A

Benzodiazepines - Antispasmodic - Antispastic Allosteric agonist at GABA receptor

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6
Q

Naproxen

A

NSAIDs - lowest CV risk FDA approve for acute gout attacks 2nd line

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7
Q

Tizanidine

A

Antispastic Agents - Central A2 Agonist (lowers BP) Drowsiness - most prominent effect (dose low) Anticholinergic - short acting

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8
Q

Diflunisal

A

NSAIDs - analgesix/antiinflam - Doesn’t cross BBB For OA/RA

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9
Q

Baclofen

A

Antispastic Agents - Inhibits GABA Inhibits Sub-P (pain) DOC for multiple sclerosis (wont reduce strength)

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10
Q

Tapentadol

A

Misc Opioid - similar to Tramadol - MU agonist SNRI Use - Diabetic Neuropathy

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11
Q

Acetaminophen (APAP)

A

Acetaminophen - Toxic metabolite NAPQI Centrally acting mild-mod nociceptive pain Good for gastric problems Hepatotoxic - greater than 4gm/D

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12
Q

Buprenorphine

A

Mixed Opioid - partial MU and KAPPA antagonist Use - detox (resists naloxone)

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13
Q

Gabapentin

A

Anticonvulsants - Analog of GABA Neuropathic pain (Off label DM neuropathy) Weight Gain

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14
Q

Bismuth Subsalicylate

A

GI Agents - Antisecretory - antimicrobial - antiinflam For Diarrhea, heartburn ADEfx - Black/Dark tongue

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15
Q

Cyclobenzaprine

A

Antispastic Agents - CNS Depressant Similar TCA structure Anticholinergic - antihistamine CI - MAOI

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16
Q

Celecoxib

A

NSAIDs - reversible COX-2 selectivity Developed to minimize GI side effects High CV risk Don’t give w/ sulfa allergy

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17
Q

Indomethacin

A

NSAIDs - non-selective COX inhibitor Accelerates PDA closure

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18
Q

Nalbuphine

A

Mixed Opioid - partial MU antagonist and KAPPA agonist Not controlled substance

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19
Q

Methocarbamol

A

Antispastic Agents - CNS depressant Urine discoloration (black, brown, green) TXT - tetanus

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20
Q

Diclofenac

A

NSAIDs - High COX-2 Selectivity Topical - OA, actinic keratosis, sprain/strains Combo w/ Misoprostol

21
Q

Diphenoxylate + Atropine

A

Opioid - local and central effects on smooth muscle of GI Inhibits GI motility Atropine - anticholinergic effects on GI Used for DIARRHEA s/s only

22
Q

Morphine

A

Opioid - Strong agonist (High MU - weak others) Least Lipophillic, histamine release ADVefx - Increases ICP, N/V, itching, HOTN

23
Q

Flurbiprofen

A

NSAIDs - Opthalmic inhibits miosis pre-surgery

24
Q

Naloxone

A

Opioid MU Antagonists Completely displaces opioids - short duration Inj can be given through clothing (Evzio -speech)

25
Tramadol
Misc Opioid - partial MU agonist and SSNRI Ultra-rapid metabolizers caution Serotinin syndrome risk
26
Rimabotulinum Toxin B
Antispastic Agents - Motor nerve Blockers Faster onset than ONA-
27
Choline Magnesium Trisalicylate
NSAIDs - Salicylate salts For OA, Acute RA flare, Shoulder pain
28
Metaxalone
Antispastic Agents - CNS Depressant Less drowsiness than others Anticholinergic - Serotonin syndrome
29
Orphenadrine
Antispastic Agents - CNS Depressant - Analgesic Diphenydranine analog (Benadryl) Anticholinergic - Antihistamine
30
Oxymorphone
Opioid - Semi synthetic MU agonist Better analgesic effect than morphine
31
Carisoprodol
Antispastic Agents - CNS Depressant Anxiolytic - sedative (Withdrawal) Not for pregnancy
32
Pregablin
Anticonvulsants - Analog of GABA Neuropathic pain - non-epileptic Weight Gain
33
Methadone
Opioid receptor agonist at all - NMDA antagonist Inhibits serotonin and NEPI reuptake For - opiod tolerant pts and detox Unpredictable t1/2
34
Salsalate (Salicylsalicylic Acid)
NSAIDs - soluble in Small intestines not gastric acid For Rheumatic D/O
35
Onabotulinum Toxin A
Antispastic Agents - Motor nerve blockers Longer and less painful inj than RIMA- Similar properties to INCO-
36
Dantrolene sodium
Antispastic Agents - For UMN D/Os Not indicated for muscle spasm of rheumatic origin Many forms like Heparin
37
Meloxicam
NSAIDs - Selective for COX-2 (lower doses) For OA/RA (1st line) Long t1/2 - once daily dosing
38
Hydrocodone ER
Opioid - MU agonist w/ low affinity Metabolized into hydromorphone
39
Oxycodone
Opioid - MU agonist w/ low affinity Metabolized to oxymorphone and noroxycodone
40
Naltrexone
Opioid MU Antagonists - Longer duration Competes but doesn’t displace CI - pts receiving opioid analgesic - withdrawal Combo w/ bupropion for weight management
41
Fentanyl
Opioid - Synthetic MU agonist Rapid onset/duration for severe chronic pain Buccal - lollipop for BT pain and combat pain relief Transdermal - 12-24H onset
42
Abobotulinum ToxinA
Antispastic Agents - Motor nerve blockers More diffuse than ONA-
43
Incobotulinum Toxin A
Antispastic Agents - Motor nerve blockers Similar properties to ONA-
44
Hydromorphone
Opioid - Metabolite of morphine - MU agonist
45
Nabumetone
NSAIDs - Prodrug - more expensive - more COX-2 selective Resembles naproxen Use OA/RA
46
Codeine
Opioid - PRODRUG metabolized into morphine Antitussive - 15mg Blackbox warno - Ultra-rapid metabolizers caution
47
Pentazocine
Mixed Opioid - Partial MU agonist and FULL kappa agon IV - epidural alternative
48
Butorphanol
Mixed Opioid - Partial MU and KAPPA agonist Forms - IV and Nasal spray

Pharm II (5 decks)

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