Pharm first half questions

Question 1

Botulinum ADEfx

Answer 1

Long acting - 12-16wks

Question 2

Codeine metabolized into

Answer 2

Morphine and Hydrocodone

Question 3

Ibuprofen dosing

Answer 3

Adult - 800mg Q6H PRN Child - 5-10mg/kg Q6H PRN

Question 4

COX - 1 sites

Answer 4

PLT, Stomach, Endothelium

Question 5

Gabapentin/Pregabalin MOA

Answer 5

Acts on excitatory synapse of GABA and reduces Glutamate thus less of a response

Question 6

APAP Overdose presentation

Answer 6

24H - minimal s/s (N/V) 24-72H - ABD pain, tender liver, high LFTs, jaundice 4D - 2 Weeks - Resolution or death

Question 7

Post Naloxone admin actions

Answer 7

911 now If not wake - naloxone can be given every 2-5m May require rescue breaths / O2

Question 8

Malignant Hyperthermia DOC

Answer 8

Dantrolene sodium IV

Question 9

C-IV drugs

Answer 9

Carisoprodol Diazepam

Question 10

Botulinum toxin uses

Answer 10

Chronic Migraines (>15D/x3mo) Cervical dystonia (Neck) and Blepharospasm (Eyelid)

Question 11

Toxin A uses

Answer 11

Cosmetic applications

Question 12

Fentanyl derivatives (infused only)

Answer 12

Sufentanil Remifentanil - Shortest t1/2 and duration, Fastest onset Alfentanil They all do not accumulate when infused

Question 13

Primary TXT of Salicylate toxicity

Answer 13

No antidote - Push bicarb - Up to 7.55 is not a CI

Question 14

COX - 2 Selective NSAIDS have what time of risks

Answer 14

More CV risks

Question 15

Acetaminophen Nomogram/Labs

Answer 15

Draw labs at 4 and 24H Read on Rumack-Matthew nomogram

Question 16

Oxycodone metabolized into

Answer 16

Oxymorphone

Question 17

Baclofen MOA

Answer 17

Mimics GABA at spine and lowers CA2+ influx at presynapse - inhibits Sub-P (pain - analgesic)

Question 18

Botulinum Antidote

Answer 18

Equine botulinum anititoxin

Question 19

CV risk top 3 non-opioid meds for pain

Answer 19

APAP, ASA, Tramadol

Question 20

Heroin metabolized into

Answer 20

Morphine

Question 21

Methocarbamol MOA

Answer 21

Suppresses spinal polysynaptic reflexes

Question 22

APAP OD antidote

Answer 22

Acetadote/Mucomyst - Glutathione precursor

Question 23

Diabetic neuropathy TXT

Answer 23

Gabapentin - Off label Tapentadol -FDA indication Peripheral neuropathy

Question 24

Dantrolene Sodium MOA

Answer 24

Interferes w/ muscle fiber couplin - reduces strength

Question 25

Codeine Controlled substance classes

Answer 25

CS-II - single ingredient CS-III - Combined w/ other analgesic CS-V - Combined w/ Guaifenesin

Question 26

Motor Nerve blockers MOA

Answer 26

Inhibits ACh release from cholinergic nerve fibers

Question 27

Multiple sclerosis DOC

Answer 27

Baclofen

Question 28

NSAID Ophthalmic preperations

Answer 28

Indomethacin - inflam or corneal abrasions Flurbiprofen - inhibits miosis presurgery Diclofenac - Post-op catarct extraction or refractive Ketorolac - Relieves ocular itching due to allergies

Question 29

DOC for PEDS w/ FLU or chicken pox

Answer 29

APAP

Question 30

Acute gouty attack DOC

Answer 30

Indomethacin

Question 31

Carisoprodol MOA

Answer 31

Blocks interneuronal activity

Question 32

Tizanidine MOA

Answer 32

Increases presynaptic inhibition

Question 33

Non-acetylated Salicylates

Answer 33

Salsalate Choline Mg Trisalicylate Diflunisal Bismouth Subsalicylate

Question 34

Anticholinergic

Answer 34

Metaxalone

Question 35

Mucomyst primary indications

Answer 35

Chronic bronchopulm DZ Cystic Fibrosis complications Atelectasis due to mucus obstruction

Question 36

Diazepam MOA

Answer 36

Allosteric agonist at GABA - increase CL- influx inhibits AP

Question 37

Serotonin syndrome drugs

Answer 37

Cyclobenzaprine Triptans Metaxalone Tramadol

Question 38

COX - 2 sites

Answer 38

Inflammatory cells and kidney