Pharm/Med Exam III Flashcards
What are medications that are not legally available without a prescription?
Legend drugs
What are legend drugs?
Drugs that are not legally available without a prescription.
What are a plant components (bark, root, seeds, flowers, fruit of trees, and extract of these plants) that are valued for their savory, aromatic, or medicinal qualities?
Herbs
What are herbs?
Plant components (bark, root, seeds, flowers, fruit of trees, and extract of these plants) that are valued for their savory, aromatic, or medicinal qualities.
What is medicine that can be bought without a prescription (doctor’s order)?
Over-the-counter medication
These represent the potential hazards of what type of medication?
- May postpone effective treatment of more chronic disease states
- May delay treatment of serious or life-threatening disorders
- May relieve symptoms of a disorder but not the cause
- Toxicity
- Interactions with current prescription medications may occur
- Abuse
Over-the-counter medication
OTC medications now account for about what percent of all medications used in the United States?
OTC medications now account for about 60% of all medications used in the United States.
A 56-year-old man is taking OTC antacids for relief of indigestion. He tells the nurse that he consumes at least one bottle a week and has done so for more than 1 month because “it works for me.” What is the nurse’s primary concern?
A. This self-treatment is expensive.
B. This self-treatment may be delaying treatment of a more serious problem.
C. This self-treatment may be the best treatment of his indigestion.
D. The long-term use of antacids may make the indigestion worse.
B - This self-treatment may be delaying treatment of a more serious problem.
The nurse associates use of which OTC medication with the development of hepatotoxicity?
A. Acetylsalicylic acid (Aspirin)
B. Ibuprofen (Motrin)
C. Pseudoephedrine (Sudafed)
D. Acetaminophen (Tylenol)
D. Acetaminophen (Tylenol) is associated with the development of hepatotoxicity.
What is the simultaneous use of both traditional and alternative medicine.
Complementary Medicine
What is complementary medicine?
Complementary Medicine- Simultaneous use of both traditional and alternative medicine.
What do you call herbal medicine, chiropractic, acupuncture, massage, reflexology, and any other therapies traditionally not emphasized in Western medical schools?
Alternative Medicine
What is alternative medicine?
What do you call herbal medicine, chiropractic, acupuncture, massage, reflexology, and any other therapies traditionally not emphasized in Western medical schools?
What is phlebitis?
Inflammation of a vein.
What are the potential hazards of over-the-counter medication?
- May postpone effective treatment of more chronic disease states
- May delay treatment of serious or life-threatening disorders
- May relieve symptoms of a disorder but not the cause
- Toxicity
- Interactions with current prescription medications may occur
- Abuse
What causes these symptoms near an IV site?
- Visible red “streaking” on your arm or leg
- Redness
- Swelling
- Warmth
- Tenderness
Phlebitis
Your patient is saying that his IV site is tender. Upon inspection you find that it is slightly pink and swollen 1-2 inches above the insertion site and it feels warm. These findings indicate:
A. Phlebitis
B. Infiltration
C. Edema
D. Thrombus
A. Phlebitis
The physician has written an order to discontinue an IV line. You obtain which of the following supplies from the supply closet to apply pressure to the site after removing the catheter.
A. Band-aid
B. Sterile 2X2 gauze
C. Alcohol swab
D. Betadine swab
B. Sterile 2X2 gauze
The nurse recognizes that the client will require fluid replacement with hypotonic solution. One of the hypotonic solutions that may be ordered by the physician is:
A. 5% sodium chloride
B. 0.45% sodium chloride
C. Dextrose 5% in 0.45% normal saline
C. Dextrose 10%
B. 0.45% sodium chloride
The nurse suspects a patient has fluid volume excess. What signs would the nurse expect to note if fluid volume excess is present?
A. Weight loss
B. Increase in blood pressure
C. Dry skin
D. Thirst
B. Increase in blood pressure
The nurse is caring for a hospitalized adult patient after thoracic surgery. The nurse observes that the patient has decreased skin turgor, dry mucous membranes, and a weak radial pulse of 100 beats/min. The nurse determines that the patient is most likely experiencing
A. Hypervolemia
B. Interstitial-to-plasma shift
C. Hypernatremia
D. Hypovolemia
D. Hypovolemia
What is it called when fluid from IV enters the subcutaneous tissue?
Infiltration
What is infiltration?
Infiltration- fluid from IV enters the subcutaneous tissue.
What type of antibiotic therapy is
used to prevent an infection?
Prophylactic
What are prophylactics?
Antibiotics that are used to prevent an infection.
What is it called when the
selection of an antibiotic is based on the possibility that it will work against the causative microorganism?
Empiric
What is Empiric Therapy?
When the selection of an antibiotic is based on the possibility that it will work against the causative microorganism.
What type of antibiotic therapy is the selection of an antibiotic when the causative organism is known?
Definitive Therapy
What are other names for pseudomembranous colitis?
Clostridium difficile or antibiotic-associated colitis.
What is pseudomembranous colitis, antibiotic-associated colitis or Clostridium difficile?
A necrotizing inflammatory bowel condition that is often associated with antibiotic therapy.
What is another term for C. diff overgrowth?
Pseudomembranous colitis or antibiotic-associated colitis.
What are the symptoms of pseudomembranous colitis?
Watery diarrhea, abdominal pain and fever.
Watery diarrhea, abdominal pain and fever are symptoms of what type of antibiotic induced condition?
Clostridium difficile or pseudomembranous colitis ( or antibiotic-associated colitis)
What antibiotic is more likely to produce Clostridium difficile than others?
Clindamycin
Clindamycin is more likely to cause what type of colitis?
Pseudomembranous colitis (antibiotic-associated colitis)
How do you treat pseudomembranous colitis (C. diff)?
More antibiotics. Especially vancomycin
What is it called when solutes move from area of higher concentration to one of lower concentration?
diffusion
What is diffusion?
When solutes move from an area of higher concentration to an area of lower concentration.
What is it called when a physiologic pump moves ions from an area of lower concentration to one of higher concentration?
Active transport
What is active transport?
When a physiologic pump is used to move ions from an area of lower concentration to one of higher concentration.
What is biotransformation?
Metabolism
What is alteration of a drug into an inactive metabolite, a more soluble compound, a more potent active metabolite called?
Metabolism or biotransformation
What is biotransformation?
Biochemical alteration of a drug into an inactive metabolite, a more soluble compound, a more potent active metabolite (as in the conversion of an inactive prodrug to its active form), or a less active metabolite.
What is this an example of: transformation of a more potent active metabolite (as in the conversion of an inactive prodrug to its active form)?
Metabolism or biotransformation
What is a prodrug converted to during biotransformation (metabolism)?
A more active form
What is required to convert a prodrug into it’s more active form?
Metabolism (biotransformation)
What are the four results of metabolism (biotransformation)
- An inactive metabolite
- A less active metabolite
- A more potent active metabolite
- A more soluble compound
What is it called when a large proportion of a drug is chemically changed into inactive metabolites by the liver.
Much smaller amount will be bioavailable.
First pass effect
What is the first pass effect?
A large proportion of a drug is chemically changed into inactive metabolites by the liver.
Much smaller amount will be bioavailable.
What amount of drug is available after the first pass effect?
A much smaller amount will be bioavailable.
Where does first pass effect happen?
In the liver
Where does a physiologic process that chemically changes a large proportion of a drug is into inactive metabolites occur?
In the liver
What is the time required for half (50%) of a given drug to be removed from the body?
Half-life
What is the half-life of a drug?
The time required for half (50%) of a given drug to be removed from the body
After how many half-lives is a drug considered effectively removed from the body?
After approximately five half-lives.
What is considered effectively removed after five passes through the liver?
A drug
What type of medication is affected by first pass effect?
PO
What is PO medication?
Oral
What type of medications are considered PO?
A drug absorbed into the systemic circulation through the oral or gastric mucosa or the small intestine.
Due to what physiological process do IV medication doses need to be lower than PO doses?
Because of the first-pass effect.
What routes of administration are considered enteral?
Sublingual, buccal, oral, and rectal routes
What percentage of a drug is bioavailable via the IV route of administration?
100%
What is a strong physical and psychologic dependence on a drug or other psychoactive substance?
Addiction
What is addiction?
A strong physical or psychological dependence on a drug or other psychoactive substance.
What is withdrawal?
A substance specific mental disorder that follows cessation or reduction of a substance.
What is a substance specific mental disorder that follows cessation or reduction of a substance?
Withdrawal
What two types of addiction occur?
- Physical dependence: physiologic reliance on a substance
- Psychologic dependence: strong desire to obtain and use a substance
What is it called when the need for a greater amount of a substance is required to produce desired effect?
Tolerance
What is drug tolerance?
When the patient needs need a greater amount of a drug to produce the desired effect.
What is the use of mood or behavior altering substances in a maladaptive manner called?
Substance abuse
What is substance abuse?
The use of mood or behavior altering substances in a maladaptive manner.
What are two types of dependence?
Physical dependence and
psychologic dependence.
What is a physiologic reliance on a substance?
Physical dependence
What is a strong desire to obtain and use a substance called?
Psychologic dependence
What is the difference between a physical and psychologic dependence on a drug?
In a physical dependence, physical withdrawal will occur.
What is the study of what the drug does to the body?
Pharmacodynamics
What is pharmacodynamics?
The study of what the drug does to the body.
What is another name for the mechanism of drug actions in living tissues?
Pharmacodynamics
Is the therapeutic effect part of pharmacodynamics or pharmacokinetics?
Pharmacodynamics because the therapeutic effect is the result of what the body does to the drug.
What types of interactions occur in pharmacodynamics?
Receptor interactions
Enzyme interactions
Non-selective interactions
Receptor interactions, enzyme interactions and non-selective interactions occur in what?
Pharmacodynamics