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HemeOnc 2 > Pharm Immuno-modulators > Flashcards

Pharm Immuno-modulators Flashcards

1
Q

cyclosporine

A
  • binds to cyclophilin
  • prophylaxis for GVHD and tx for uveitis
  • metabolized by P4503A; multidrug interactions
  • induces TGF-B, promotes tumor invasion & metastasis; increases incidence of lymphomas and Kaposi’s
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2
Q

tacrolimus

A
  • same indications as cyclosporine
  • standard prophylaxis for GVHD
  • metabolized by P450 system
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3
Q

sirolimus

A
  • blocks mTOR & response of T cells to cytokines
  • same uses as tacrolimus
  • only available in oral formulation
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4
Q

mycophenolate mofetil

A
  • inhibits inosine monophosphate dehydrogenase
  • tx for refractory rejection
  • alternative to cyclosporine or tacrolimus
  • prophylaxis for GVHD
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5
Q

alemtuzumab

A
  • binds CD52

- tx refractory B-cell ALL in pts on alkylators and that have failed fludarabine therapy

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6
Q

bevacizumab

A
  • binds and inhibits VEGF
  • anti-angiogenic drug = inhibit blood vessel growth in tumors
  • first line tx for metastatic colorectal CA
  • can be used alone or w/ chemo
  • contraindications = SBP >160 & 2+ or greater proteinuria on UA
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7
Q

cetuximab

A
  • targets EGFR
  • inhibits tumor cell growth by decr kinase activity, matrix metalloproteinase activity, and incr apoptosis
  • tx for metastatic colorectal CA b/c the tumor over-expresses EGFR
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8
Q

gemtuzumab

A
  • specific for CD33 which is expressed on leukemic blast cells in pts w/ AML
  • tx for relapsed CD33 AML
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9
Q

rituximab

A
  • binds CD20 on malignant B lymphocytes

- tx for pts w/ relapsed or refractory low-grade or follicular B-CELL NHL

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10
Q

trastuzumab

A
  • binds human epidermal growth factor receptor (HER-2)

- tx of metastatic breast CA in pts w/ tumors that over-express HER-2

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11
Q

tx of goodpasture syndrome

A
  • prednisolone
  • cyclophosphamide
  • plasma exchange
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12
Q

tx of sjogren’s

A
  • hydroxychloroquine (Plaquenil)
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13
Q

tx of psoriasis

A
  • betamethasone (dipropionate)

- cyclosporine

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14
Q

tx of dermatomyositis

A
  • prednisone
  • methotrexate
  • azathioprine
  • mycophenolate
  • hydroxychloroquine
  • chloroquine
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15
Q

tx of SLE

A
  • steroids (prednisolone pills; methylprednisolone IV)
  • cyclophosphamide
  • azathioprine
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16
Q

tx of vasculitis

A
  • steroids
  • cyclophosphamide
  • azathioprine
  • plasma exchange
17
Q

standard drugs for prophylaxis of GVHD; why would you choose each?

A
  • cyclosporine = kidney, liver, pancreas, heart transplants
  • tacrolimus = alternative to cyclosporine; no special indications
  • mycophenolate mofetil = refractory rejection

HemeOnc 2 (4 decks)

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