HIV Drug s/e

Question 1

indinavir

Answer 1

kidney stones

Question 2

emtricitabine & lamivudine

Answer 2

• M184V

- low genetic barrier

Question 3

zidovudine

Answer 3

hyperchromic macrocytic anemia

- would see increased MCV and MCHC elevated

Question 4

tenofovir

Answer 4

renal s/e

Question 5

sustiva

Answer 5

neuro s/e

dizziness and vivid nightmares

Question 6

atazanavir

Answer 6

bilirubin elevation

can’t use w/ PPIs

Question 7

lopinavir

Answer 7

GI sx predominate

will elevate lipids

Question 8

what other drugs do ARVs interact with

Answer 8

ED meds
PPIs
statins
Ca channel blockers
grapefruit juice
St. John's wort
- all require dose adjustments

Question 9

recommended regimens for HAART

Answer 9

• NNRTI + 2 NRTI
• PI (preferably boosted w/ ritonavir) + 2 NRTI
• INSTI + 2 NRTI