Pharm II - Test 2 Flashcards
Which antidepressant class has the most significant side effects profile?
Monoamine oxidase inhibitors (MAOI)
Which antidepressant class requires dietary recommendations (restriction of tyramine-containing foods)
Monoamine oxidase inhibitors (MAOI)
What is the risk of combining MAOIs with foods high in tyramine?
MAO usually breaks down tyramine -> Inc. absorption of intact tyramine -> toxic elevation of catecholamines -> severe HA, N, HTN (potentially hypertensive emergencies)
Class: Amitriptyline (Elavil)
Tricyclic antidepressant
Indication: Amitriptyline (Elavil)
Major depression, bipolar d/o, migraine/tension HA (prophylaxis), chronic pain
MOA: Amitriptyline (Elavil)
CNS modulation of both serotonin and norepinephrine
Side effects: Amitriptyline (Elavil)
Anticholinergic effects (dry mouth, constipation, urinary hesistancy, blurred vision)
Which antidepressant does not have the side effect of weight gain?
Wellbutrin
Class: Trazodone (Desyrel)
Tetracyclic antidepressant
Indication: Trazodone (Desyrel)
MDD, anxiety, panic disorder, insomnia
MOA: Trazodone (Desyrel)
Serotonin reuptake inhibitor and partial antagonist (SARI)
Class: Fluoxetine (Prozac)
Selective serotonin reuptake inhibitor (SSRI)
Indication: Fluoxetine (Prozac)
MDD, OCD, bulimia, panic disorder
MOA: Fluoxetine (Prozac)
Dec serotonin reuptake at presynaptic cleft -> inc serotonin for neurotransmission
Side effects: Fluoxetine (Prozac)
Serotonin syndrome (fever, agitation, D, hypertension), sexual dysfxn (dec libido, impotency, anorgasmia)
What drugs can interfere and reduce the efficiency of SSRIs?
Aspirin, Ibuprofen, Naproxen
Class: Duloxetine (Cymbalta)
Serotonin and norepinephrine reuptake inhibitor (SNRI)
Indication: Duloxetine (Cymbalta)
MDD, general anxiety, PAINFUL PERIPHERAL NEUROPATHY, FIBROMYALGIA
Class: Bupropion (Wellbutrin)
Norepinephrine and dopamine reuptake inhibitors (NDRI) and nicotine receptor antagonist
Indication: Bupropion (Wellbutrin)
MDD, bipolar do, ADD, smoking cessation (Zyban)
MOA: Bupropion (Wellbutrin)
Blockade of NE and DOPA reuptake
Addition of what nutrient may improve SSRI response?
Folic acid
What is the brand name of activated folic acid?
Deplin
Ultra-short acting barbiturate
Thiopental (Pentothal)
Short-acting barbiturate
Pentobarbital (Nembutal)
Intermediate-acting barbiturate
Butalbital (Fiorinal)
Long-acting barbiturate
Phenobarbital (Luminal)
What is the most widely used anticonvulsant worldwide?
Phenobarbital (Luminal)
What are the most widely used group of anxiolytic drugs?
Benzodiazepines
Indication: Midazolam (Versed)
Sedation/anxiety prior to upper/lower GI endoscopy
Acute mgmt of aggressive, violent, or delirious patients
Midazolam (Versed) is not indicated for ___.
long-term mgmt of seizure disorders
Class: Diazepam (Valium)
Benzodiazepine anticonvulsant
Indication: Diazepam (Valium)
Anxiolytic, sedative, muscle relaxant, STATUS EPILEPTICUS
MOA: Diazepam (Valium)
Binds to benzodiazepine receptors in CNS to enhance GABA activity -> inc Cl- influx -> inhibition of CNS synaptic transmission
MOA: Benzodiazepine-like sedatives
Increase GABA receptor affinity for GABA by binding to site different than benzo or barbiturate site
Class: Zolpidem (Ambien)
Short-acting, non-benzodiazepine hypnotic
Class: Eszopiclone (Lunesta)
Benzodiazepine-like hypnotic
Indications: Zolpidem (Ambien)
Trouble falling asleep, but not necessarily maintaining sleep
Indication: Eszopiclone (Lunesta)
Insomnia
MOA: Eszopiclone (Lunesta)
Potentiation of GABA effect on Cl- ion channels
Class: Ramelteon (Rozerem)
Melatonin receptor agonist
Class: Fumazenil (Romazicon)
Benzodiazepine receptor antagonist
Indication: Fumazenil (Romazicon)
Reverse effects of benzos
The chief antipsychotic effects of neuroleptics appear related to blockade of ___ in the ___
dopamine D2 receptors, mesolimbic pathway
Neuroleptic malignant syndrome
Rare side effect of neuroleptic use characterized by catatonia, fluctuating BP, dysarthria, fever
Tx: Neuroleptic malignant syndrome
Dopamine agonist (Bromocriptine)
Class: Chlorpromazine (Thorazine)
Typical neuroleptic
MOA: Chlorpromazine (Thorazine)
D2 dopaminergic receptor blocker
Alpha-adrenergic blocker
H1-histamine blocker
Side effect: Chlorpromazine (Thorazine)
INC RELEASE OF PRL
Neuroleptic side effects (Sedation, dizziness, HA, D, Extrapyramidal effects)
Class: Prochlorperazine (Compazine)
Typical neuroleptic
Indication: Prochlorperazine (Compazine)
Better anti-emetic than other neuroleptics
MOA: Prochlorperazine (Compazine)
H1-histaine receptor antagonist
Alpha-adrenergic receptor antagonist
D2 dopaminergic receptor antagonist
Class: Haloperidol (Haldol)
Typical neuroleptic
Indication: Haloperidol (Haldol)
Psychosis, Tourette’s syndrome, Huntington’s disease, ACUTE AGITATED BEHAVIOR