Pharm II lecture 4 Flashcards

1
Q

tenesmus

A

The feeling of having to have a bm but is empty

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2
Q

rectum is usually involved

A

UC

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3
Q

transmural disease

A

crohn’s disease

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4
Q

skip lesion

A

Crohn’s disease

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5
Q

Severity for UC

A

-number of stools per day
-presence of blood
-systemic disturbance

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6
Q

crohn’s disease severity

A

-ability to complete normal activity
-ability to tolerate oral nutrition
-weight loss

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7
Q

trigger for flares

A

smoking and NSAIDs

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8
Q

corticosteroid

A

mild treatment for UC

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9
Q

corticosteriod meds

A

budesonide foam, hydrocortisone foam/enema

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10
Q

AE of corticosteroid

A

leukocytosis and hyper glycemia

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11
Q

limit the use of corticosteroids for

A

4 months

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12
Q

instruction for intake of corticosteroid

A

swallow whole, do not crush or chew

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13
Q

budesonide (entocort)

A

oral - designed to release in terminal ileum or colon

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14
Q

Aminosalicylate

A

primarily used for UC

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15
Q

prototypical aminosalicylate

A

sulfasalazine

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16
Q

Which meds cause yellow/orange discoloration of urine

A

sulfasalazine

17
Q

foam

A

rectum to the sigmoid

18
Q

enema

A

up to the splenic flexure

19
Q

canasa suppository

A

retain at least 1-3 hours

20
Q

rowasa enema

A

retain for 8 hours

21
Q

methotrexate

A

used for chron’s disease

22
Q

contraindication for methotrexate

A

pregnancy

23
Q

box warning for methotrexate

A

hepatoxicity w/alcohol, GI toxicity

24
Q

Thiopurines

A

used for UC and crohn’s

25
Q

What needs to be monitored when you use Thiopurines

A

TPMT - metabolize azothioprine

26
Q

box warning for biologics

A

TB, hepatitis, lymphoma

27
Q

MOA of xelijanz

A

JAK inhibitor

28
Q

cyclosporine usage

A

attempt to avoid volectomy in pt with UC failing corticosteroid therapy

29
Q

mild UC treatment

A

5- ASA

30
Q

Mild treatment for Crohn’s

A

Budesonide (entocort)

31
Q

MTX is used for

A

moderate/severe Crohn’s disease

32
Q

Diverticula

A

sac like profusion of the colonic wall

33
Q

diverticulosis

A

presence of diverticula

34
Q

diverticulitis

A

inflammation or infection of diverticula