Pharm II lecture 4 Flashcards
tenesmus
The feeling of having to have a bm but is empty
rectum is usually involved
UC
transmural disease
crohn’s disease
skip lesion
Crohn’s disease
Severity for UC
-number of stools per day
-presence of blood
-systemic disturbance
crohn’s disease severity
-ability to complete normal activity
-ability to tolerate oral nutrition
-weight loss
trigger for flares
smoking and NSAIDs
corticosteroid
mild treatment for UC
corticosteriod meds
budesonide foam, hydrocortisone foam/enema
AE of corticosteroid
leukocytosis and hyper glycemia
limit the use of corticosteroids for
4 months
instruction for intake of corticosteroid
swallow whole, do not crush or chew
budesonide (entocort)
oral - designed to release in terminal ileum or colon
Aminosalicylate
primarily used for UC
prototypical aminosalicylate
sulfasalazine
Which meds cause yellow/orange discoloration of urine
sulfasalazine
foam
rectum to the sigmoid
enema
up to the splenic flexure
canasa suppository
retain at least 1-3 hours
rowasa enema
retain for 8 hours
methotrexate
used for chron’s disease
contraindication for methotrexate
pregnancy
box warning for methotrexate
hepatoxicity w/alcohol, GI toxicity
Thiopurines
used for UC and crohn’s
What needs to be monitored when you use Thiopurines
TPMT - metabolize azothioprine
box warning for biologics
TB, hepatitis, lymphoma
MOA of xelijanz
JAK inhibitor
cyclosporine usage
attempt to avoid volectomy in pt with UC failing corticosteroid therapy
mild UC treatment
5- ASA
Mild treatment for Crohn’s
Budesonide (entocort)
MTX is used for
moderate/severe Crohn’s disease
Diverticula
sac like profusion of the colonic wall
diverticulosis
presence of diverticula
diverticulitis
inflammation or infection of diverticula
