Pharm II

Question 1

T or F. The lungs contain CYPS and other enzymes that are responsible for changing the composition of inhaled material

Answer 1

T. In addition to creating metabolites, these enzymes can be responsible for activating pro-carcinogenic materials

Question 2

While the nasal passages are highly vascularized and are excellent spots for administering drugs for quick uptake, certain things can inhibit quick uptake. Namely:

Answer 2

-Common cold produces lots of mucus

Question 3

What is the fluid capacity of each nostril?

Answer 3

200ul

Question 4

What is one potential effect of nasal delivery?

Answer 4

Access to the CNS via the olfactory and trigeminal nerves that bypass the BBB

Question 5

What is Naloxone?

Answer 5

Narcan.. Opiod antagonist

Question 6

Why is Narcan available nasally?

Answer 6

Even though its onset is slower (8-13 min), its easy for normal people to use

Question 7

What is the main diff between 1st and 2nd generations of antihistamines?

Answer 7

1st gen crosses the BBB and leads to sedation

Question 8

What is a common adverse effect of frequent use of corticosteroids in asthmatics?

Answer 8

stunting of growth of long bones in children

Question 9

How is PAH treated?

Answer 9

• prostanoids
• endothelin antagonists
• PDE-5 antagonists

Question 10

What is a down-side of prostanoids?

Answer 10

short duration of action

Question 11

What are the major respiratory infections?

Answer 11

• pneumonia

- Mycobacterium TB

Question 12

Hemorrhage is a common side effect of targeted therapy for cancers that target ____.

Answer 12

VEGF