Pharm I Final Exam Crossword Puzzle Answers

Question 1

Urinary excretion of a weak acid will be increased in this kind of urine:

Answer 1

alkaline

Question 2

Diffusion hypoxia can occur on recovery from nitrous oxide and is called the _____ effect

Answer 2

fink

Question 3

An anesthetic induction agent that suppresses adrenal function:

Answer 3

etomidate

Question 4

Ketamine blocks this receptor:

Answer 4

NMDA

Question 5

An anesthetic induction agent that is a neurosteroid:

Answer 5

alphaxalone

Question 6

Apomorphine induces emesis in dogs not through opioid receptors but instead ______ receptors in the CRTZ

Answer 6

dopamine

Question 7

This gene encodes the P-glycoprotein efflux pump:

Answer 7

MDR1

Question 8

An ‘enzyme inducer’ typically increases the activity of the Cytochrome ____ group of microsomal enzymes

Answer 8

P450

Question 9

Drug class with inconsistent sedation but good muscle relaxation, useful in old and ‘sick’ patients:

Answer 9

benzodiazepine

Question 10

This route of administration is assumed to have 100% bioavailability

Answer 10

IV

Question 11

Specific reversal agent for carfentanil:

Answer 11

naltrexone

Question 12

A prodrug gets converted to an active drug by this mechanism:

Answer 12

bioactivation

Question 13

Oxybutinin and propantheline cause the detrusor muscle of the bladder to _______

Answer 13

relax

Question 14

Diazepam should not be used via this route because of poor absorption and pain:

Answer 14

IM

Question 15

Pilocarpine will cause the pupil to do this:

Answer 15

constrict

Question 16

The endogenous ligand for NMDA receptors:

Answer 16

glutamate

Question 17

In this state a drug cannot easily cross lipid membranes:

Answer 17

ionized

Question 18

The main inhibitory neurotransmitter in the CNS:

Answer 18

GABA

Question 19

Neostigmine, edrophonium and carbamate insecticides are all examples of this type of parasympathomimetics

Answer 19

indirect

Question 20

Atropine ophthalmic should not be used in in patients with ______

Answer 20

Glaucoma

Question 21

Glomerular filtration is a (passive/active) process:

Answer 21

passive

Question 22

Synthetic mixed agonist/antagonist that is available in injectable and oral formulations:

Answer 22

butorphanol

Question 23

A class of sedatives that is known to cause ‘epinephrine reversal’

Answer 23

phenothiazines

Question 24

The most common Phase II reaction:

Answer 24

glucoronidation

Question 25

Combined with Tiletamine in the product 'Telazol'

Answer 25

**zolazepam**

Question 26

The most common negative effect of acepromazine:

Answer 26

**hypotension**

Question 27

2% lidocaine solution contains ___ mg/mL lidocaine

Answer 27

**20**

Question 28

Alpha-2 agonists can cause profound:

Answer 28

**bradycardia**

Question 29

The ______ of drug eliminated per unit of time is consistent for drugs that follow first-order elimination

Answer 29

**proportion**

Question 30

Opioid that also has activity at NMDA receptors

Answer 30

**methadone**

Question 31

As Vd increases half-life \_\_\_\_\_\_\_\_

Answer 31

**increases**

Question 32

Reversal agent for xylazine, not a good choice to reverse dexmedetomidine

Answer 32

**yohimbine**

Question 33

The metabolic process by which an orally administered drug is absorbed but very little reaches systemic circulation, as with morphine:

Answer 33

**first pass**

Question 34

Nitrous oxide provides (good/poor) muscle relaxation:

Answer 34

**poor**

Question 35

A form of transmembrane transport that requires energy input (direct or indirect) to function:

Answer 35

**active**