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Emma Micro II > Pharm - HIV - General > Flashcards

Pharm - HIV - General Flashcards

1
Q

protease inhibitors

A 
lopinavir
rotinavir
indinavir
atazanavir
darunavir
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2
Q

NRTIs

A

zidovudine
stavudine
didanosine

tenofovir
lamivudine
emtricitabine
abacavir

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3
Q

NNRTIs

A 
nevirapine
efavirenz
delavirdine
rilpivirine
doravirine
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4
Q

integrase inhibitors

A

raltegravir
bictegravir
dolutegravir
eluitegravir

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5
Q

fusion inhibitors

A

enfuvirtide

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6
Q

docking inhibitors

A

maraviroc (blocks CCR5 on macrophage)

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7
Q

protease inhibitors

MOA/AE

A

(-navir)

MOA: inhib HIV protease, viral particles can bud off but are immature/noninfectious

AE: 
nausea/diarrhea
HLD
hypERglycemia 
lipodystrophy (buffalo bump)
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8
Q

____ are often given with a booster to inc drug levels

A

protease inhibitors

booster=ritonavir, cobicistat

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9
Q

protease inhibitors

resistance

A

Highly potent, resistance slow to occur

*never use as monotherapy

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10
Q

ritonavir AE

A

inhib p450 –> drug-drug interactions

protease inhibitor booster

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11
Q

atazanavir

A

indirect hyperbilirubinemia

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12
Q

NRTI

MOA/AE

A

MOA: mimic structures of nucleotides (but lack -OH), allosterically bind RT, halts chain growth

AE: mitochondrial toxicity

  • peripheral neuropathy
  • myopathy
  • pancreatitis
  • lactic acidosis
  • peripheral lipotrophy (subQ loss)
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13
Q

which NRTI is actually a nucleotide

A

tenofavir

nucleotide + 1 P

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14
Q

Which HIV tx are also active against HBV?

A

Tenofavir
Emtricitabine
Lamviudine

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15
Q

abacvir AE

A

MI

HS rxn if HLAB*5701 +

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16
Q

tenofovir AE

A

nephrotoxicity (falconi)

bone density

17
Q

PrEP

A

tenovir and emtricitabine

18
Q

NNRTIs

MOA/AE

A

MOA: competitively inhibit RT and deform active site

AE: 
GI rash (rarely severe SJS)
drug interactions (p450)
hepatotoxicity
nephrotoxicity
some CNS
19
Q

efavirenz AE

A

CNS effects (impaired concentration, vivid dreams/nightmares, depression, dizziness, trouble sleeping)

TERATOGEN

(NNRTI)

20
Q

rilpivarine AE

A

AE: hepatotoxic, don’t use in pt w/ adv HIV

NNRTI

21
Q

initial HIV therapy regimen

A

2 NRTIs and an integrase inhibitor

Emma Micro II (10 decks)

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