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pharm final Flashcards

1
Q

Causes vasodilation by blocking L-type calcium channels

A

Felodopine

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2
Q

Movement of sodium with what phase of cardiac AP

A

Phase 0

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3
Q

positive of statin

A

Improves endothelial function

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4
Q

Sildenafil

A

Phosphodiesterase 5 inhibitor

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5
Q

On ACE inhibitor that gives cough, what can they swith to so no cough

A

ValsartaN

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6
Q

epi

A

neurotransmitter

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7
Q

Drug with zero order kinetics

A

phenytoin

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8
Q

Catalyzes rate limiting step

A

lovastatin

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9
Q

First step in atherogenesis

A

endothelial dysfunction

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10
Q

Blocks angiotensin II at At1 receptor:

A

Candesartan

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11
Q

Morphine can produce diff responses in diff tissues because:

A

heterogeneity of G proteins allows diff actions on downstream effectors

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12
Q

Intracellular concentration key in smooth muscle tone

A

calcium

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13
Q

organ responsible for first pass?

A

liver

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14
Q

depolarizing paralytic

A

succinylcholine sh

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15
Q

70% of drug is bound

A

70% of drug is bound: 30% is unbound

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16
Q

dose response curve when add compet antag

A

shifts right

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17
Q

Inhibits COX1 preventing formation of thromboxane A?

A

Aspirin

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18
Q

alpha -1 receptor =

A

ncreases sympathetic tone

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19
Q

FDA definition of drug

A

intended for use in diagnosis, cure, treatment or prevention of
disease

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20
Q

lipoprotein with lowest portion of triglycerides

A

HDL

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21
Q

gynecomastia in men caused by

A

spironolactone

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22
Q

1 transmembrane span in resting state

A

insulin receptor

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23
Q

irreversible bond

A

covalent

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24
Q

Prevents prothrombin to thrombin

A

factor Xa inhibitor

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25
Q

.HMG co A good target because

A

rate limiting step in synthesis of cholestorl

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26
Q

. Basic drug in basic PH

A

non ionized, deprotonated

27
Q

amount of drug absorbed per amount administed

A

bioavailability

28
Q

Area between min effective concentration and min toxic concentration

A

therapeutic window

29
Q

Optimal level for triglycerides?

30
Q

Opioid receptor competitively antagonized by

31
Q

Prevents conversion of prothrombin to thrombin by factor Xa =

A

factor Xa inhibitors

32
Q

Vasodilator that increases intracellular nitrci oxide concentration?

A

Sodium Nitroprusside

33
Q

Exaggerated immunological response

A

allergic reaction

34
Q

half life =

35
Q

Arythmia >100 beats per minute

A

tachycardia

36
Q

Beta blocker

37
Q

Drug must be bound to protein to elicit effect

38
Q

Beta blocker safest for severe asthma?

A

Metoprolol

39
Q

Severe cholinergic toxicity, what is atropine NOT effective in treating?

40
Q

What binds to diff site than the agonist?

A

Allosteric antagonist

41
Q

Alpha adrenergic antagonists that can occur if patient gets up to quickly from chair

A

alpha 1

blockade: orthostatic hypotension

42
Q

Side effect of hair growth

43
Q

Lipoprotein lipase is what role in exogenous pathway?

A

Metabolized chylomicrons to release triglycerides

44
Q

MTC

A

minimum toxic concentration

45
Q

Ligand binding domain on the inside of cells-

A

steroid receptors

46
Q

Plasma proteins are good targets for:

A

monoclonal antibodies

47
Q

Testosterone induces:

A

gene transcription and translation to increase protein synthesis

48
Q

Dry mouth and sedation

A

Diphenhydramine (benadryl)

49
Q

Insulin receptors form homodimers that phosphorylat intracellular proteins at sites
containing

50
Q

alpha agonist can be used as nasal decongestant and for short term hypotension

A

phenylephrine

51
Q

IV doses, bioavailability =

52
Q

Positive pleiotropic effect of statins

A

improved endothelial function

53
Q

Medication inhibits the final common pathway in platelet aggregation

A

eptifibatide

54
Q

Aspirin overdose, to get it to leave you

A

alkalinize the urine

55
Q

myocardial oxygen demand determinant

A

heart rate

56
Q

Which is not an NOAC

57
Q

Weak base trapped in ___ weak acid in ____?

A

Acidic, alkaline

58
Q

sympathetic, post ganglion neuron release

59
Q

7 transmembrane receptor

A

opioid mu receptor

60
Q

acidic drug, acidic ph - non ionized, protonated

A

acidic drug, acidic ph - non ionized, protonated

61
Q

Beta 2 adrenergic receptors

A
  • triggers bronchodilation
62
Q

1994 DSHEA :

A

prohibited full FDA review on supplements and botanicals as drugs

63
Q

Quaternary amine:

A

glycopyrrolate

A (4 decks)

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