First Half of Pharm Final Flashcards
Following agonist activation of opioid mu receptors, amplification of downstream signal
occurs because
duration of action of g protein is longer than agonist activation of
receptor
Anti epileptic with cognitive impairment, gingival hyperplasia and drug interactions of
cyp450 3A4 enzyme induction?
phenytoin
antianginal med works by blocking beta adrenoceptor :
atenolol
Three endogenous catecholamines
norepi, epi and dopamine?
Cardiac output is a function of HR and
Stroke volume
Which of the following is true regarding the intrinsic pathway-
All components are present in
the blood
”the index of how well a drug is removed irreversibly from circulation?
Clearance?
RV
.preferred dose and rout for epi in anaphylaxis?
0.3mg IM
“Predictable, dose related reaction not part of the desired therapeutic effect-
side effect
.levoflxacin is 2C9 inhibitor, warfarin is 2c9 substrate, what happens if taken together:
increased warfarin effect
Results from covalent mod and alteration of DNA?
Mutagenesis
how many chemicals might have to be screened and tested in orer to generate one useful
therapeutic -
1000
Ionized form of a drug more readily crosses plasma membrane
false
32 yo patient, taking lots of drugs, which is the reason for platelet reduction
depakote
after FDA approval how long is left of patent life?
5-10 years
beta 2 agonist for short term control in asthma:
albuterol
Vaugh williams classification of calcium channel blocker
class IV
What happens to EC50 when competitive agonist added
shifts right
High intensity drug/dose?
Atorvasatin (Lipitor) 80mg
Superfamily of receptors bound to heat shock proteins in ctyoplasm of nucleus:
Steroid receptors
competively inhibits conversion of plasminogen to plasmin by TPA?
Tranexamic acid
Which drug associated with anaphylactic shock
penecillin
.dry secretions and increase hr in nerve agent exposure:
atropine
Regenerates Achesteras after nerve agents
Pralidoxime
.patient using albuterol for asthma, which medication is most likely to result in
pharmacodyamic interaction and negate use?
propranolol
class of lipid lowering agents most potent lowering LDL cholesterol, also expensive?
PCSK9 inhibitors
.study of genetic basis of ADME and receptor target interactions:
pharmacogenomics
Enzyme responsible for breaking down acetylcholine in serum
acetycholinesterase
taking APAP with codeine, what effects can it have on other meds they take?
Slowed
absorption
taking APAP with codeine, what effects can it have on other meds they take?
Slowed
absorption
A drug must be bound to be effective
false
clot occurs in arterial circulation and consists of platelets?
white thrombus
avoid all in asthma
aspirin/nsaids, opiates and barbiturates and antihistamines
Non-covalent type of interaction:
formation of hydrogen peroxide
antianginal medication with gingival hyperplasia
dilitiazem
direct thrombin inhibitor
pradaxa
Which would you not expect with acute cholinergic toxicity
dry mouth
One transmembrane spanning domain
insulin receptor
Drug for chronic dry mouth, avoid adverse effects while max stimulation of saliva:
M3 receptors
property of drug gives ability to bind to several subtypes of adrenergic receptors?
Multiple
steroisomers
. In pregnancy have drug variation due to
increased RBF and GFR
Positive inotropic that increase gag reflex:
digoxin
Colesevelam
binding to bile acid and preventing resorption
dynamic
- drug on boday kinetics - body on drug
Causes vasodilation by blocking l-type calcium channels
felodipine
