First Half of Pharm Final

Question 1

Following agonist activation of opioid mu receptors, amplification of downstream signal
occurs because

Answer 1

duration of action of g protein is longer than agonist activation of
receptor

Question 2

Anti epileptic with cognitive impairment, gingival hyperplasia and drug interactions of
cyp450 3A4 enzyme induction?

Answer 2

phenytoin

Question 3

antianginal med works by blocking beta adrenoceptor :

Answer 3

atenolol

Question 4

Three endogenous catecholamines

Answer 4

norepi, epi and dopamine?

Question 5

Cardiac output is a function of HR and

Answer 5

Stroke volume

Question 6

Which of the following is true regarding the intrinsic pathway-

Answer 6

All components are present in

the blood

Question 7

”the index of how well a drug is removed irreversibly from circulation?

Answer 7

Clearance?

RV

Question 8

.preferred dose and rout for epi in anaphylaxis?

Answer 8

0.3mg IM

Question 9

“Predictable, dose related reaction not part of the desired therapeutic effect-

Answer 9

side effect

Question 10

.levoflxacin is 2C9 inhibitor, warfarin is 2c9 substrate, what happens if taken together:

Answer 10

increased warfarin effect

Question 11

Results from covalent mod and alteration of DNA?

Answer 11

Mutagenesis

Question 12

how many chemicals might have to be screened and tested in orer to generate one useful
therapeutic -

Answer 12

1000

Question 13

Ionized form of a drug more readily crosses plasma membrane

Answer 13

false

Question 14

32 yo patient, taking lots of drugs, which is the reason for platelet reduction

Answer 14

depakote

Question 15

after FDA approval how long is left of patent life?

Answer 15

5-10 years

Question 16

beta 2 agonist for short term control in asthma:

Answer 16

albuterol

Question 17

Vaugh williams classification of calcium channel blocker

Answer 17

class IV

Question 18

What happens to EC50 when competitive agonist added

Answer 18

shifts right

Question 19

High intensity drug/dose?

Answer 19

Atorvasatin (Lipitor) 80mg

Question 20

Superfamily of receptors bound to heat shock proteins in ctyoplasm of nucleus:

Answer 20

Steroid receptors

Question 21

competively inhibits conversion of plasminogen to plasmin by TPA?

Answer 21

Tranexamic acid

Question 22

Which drug associated with anaphylactic shock

Answer 22

penecillin

Question 23

.dry secretions and increase hr in nerve agent exposure:

Answer 23

atropine

Question 24

Regenerates Achesteras after nerve agents

Answer 24

Pralidoxime

Question 25

.patient using albuterol for asthma, which medication is most likely to result in
pharmacodyamic interaction and negate use?

Answer 25

propranolol

Question 26

class of lipid lowering agents most potent lowering LDL cholesterol, also expensive?

Answer 26

PCSK9 inhibitors

Question 27

.study of genetic basis of ADME and receptor target interactions:

Answer 27

pharmacogenomics

Question 28

Enzyme responsible for breaking down acetylcholine in serum

Answer 28

acetycholinesterase

Question 29

taking APAP with codeine, what effects can it have on other meds they take?

Answer 29

Slowed

absorption

Question 30

taking APAP with codeine, what effects can it have on other meds they take?

Answer 30

Slowed

absorption

Question 31

A drug must be bound to be effective

Answer 31

false

Question 32

clot occurs in arterial circulation and consists of platelets?

Answer 32

white thrombus

Question 33

avoid all in asthma

Answer 33

aspirin/nsaids, opiates and barbiturates and antihistamines

Question 34

Non-covalent type of interaction:

Answer 34

formation of hydrogen peroxide

Question 35

antianginal medication with gingival hyperplasia

Answer 35

dilitiazem

Question 36

direct thrombin inhibitor

Answer 36

pradaxa

Question 37

Which would you not expect with acute cholinergic toxicity

Answer 37

dry mouth

Question 38

One transmembrane spanning domain

Answer 38

insulin receptor

Question 39

Drug for chronic dry mouth, avoid adverse effects while max stimulation of saliva:

Answer 39

M3 receptors

Question 40

property of drug gives ability to bind to several subtypes of adrenergic receptors?

Answer 40

Multiple

steroisomers

Question 41

. In pregnancy have drug variation due to

Answer 41

increased RBF and GFR

Question 42

Positive inotropic that increase gag reflex:

Answer 42

digoxin

Question 43

Colesevelam

Answer 43

binding to bile acid and preventing resorption

Question 44

dynamic

Answer 44

• drug on boday kinetics - body on drug

Question 45

Causes vasodilation by blocking l-type calcium channels

Answer 45

felodipine