Pharm - Drugs for Diarrhea and Inflammatory Bowel Disease

Question 1

Antibiotic Tx for hepatic encephalopathy

Answer 1

Rifaximin

Question 2

Unlabeled use in Tx of C diff diarrhea

Answer 2

Rifaximin

Question 3

Inhibits bacterial RNA sythess by binding to bacterial DNA-dependent RNA polymerase

Answer 3

Rifaximin

Question 4

Rifamycin derivative

Answer 4

Rifaximin

Question 5

First in class agent useful for different types of secretory diarrhea. Oral delayed release

Answer 5

Crofelemer

Question 6

Inhibits CFTR channel, Ca activated Cl channel (CaCC)

Answer 6

Crofelemer

You’re basically giving yourself Cystic Fibrosis. Respiratory SEs aligned with this concept

Question 7

Provides relief for NONINFECTIOUS diarrhea. Especially for HIV/AIDS pts

Answer 7

Crofelemer

Question 8

Must rule out infectious diarrhea before use

Answer 8

Crofelemer

Question 9

Significant adverse rxn related to URI, bronchitis

Answer 9

Crofelemer

Question 10

Human monoclonal Abs

Answer 10

Adalimumab and Golimumab

Question 11

SQ induction dose followed by maintenance doses every other week

Answer 11

Adalimumab

Question 12

SQ autoinjector or self-injection that begins with induction doses and maintenance doses every 4 weeks

Answer 12

Golimumab

Question 13

Chimeric (mouse/human) antibody that neutralizes TNF alpha, preventing binding to its receptor

Answer 13

Infliximab

Question 14

IV chimeric antibody

Answer 14

Infliximab

Question 15

Its target is integrin

Answer 15

Vedolizumab

Question 16

Anti TNF agents are used to treat which Dz?

Answer 16

Ulcerative colitis

Question 17

Targets alpha4beta1 inhibiting VCAM and alpha4beta7

Answer 17

Natalizumab

Question 18

Blocks alpha4beta7-integrin only

Answer 18

Vedolizumab

Question 19

Leads to progressive multifocal leukoencephalopathy (PML)

Answer 19

Natalizumab

Question 20

5-ASA bound by an azo bond inhibiting prostaglandins and leukotrienes

Answer 20

Basalazide

(Also Sulfasalazine, Osalazine) they are prodrugs for mesalazine “5-ASA”