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GI & Liver Fall 2013 CBD > Pharm Drugs affecting Salivary Flow > Flashcards

Pharm Drugs affecting Salivary Flow Flashcards

1
Q

cevimiline [Evoxac] indication & mechanism

A

xerostomia
M3»M1 agonist

CI: asthma, closed angle glaucoma, iritis

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2
Q

pilocarpine [Pilocar] indication & mechanism

A 
xerostomia
muscarinic agonist (nonselective)

CI: asthma, closed angle glaucoma, iritis

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3
Q

amifostine [Ethyol] indication & mechanism

A

xerostomia. radioprotectant for people undergoing XRT. preserves salivary function while protecting from radiation. Treatment of tumors still works.

free radical scavenger

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4
Q

6 drug classes that induce xerostomia

A 
antihistamines
decongestants
antidepressants
antipsychotics
antihypertensives
anticholinergics
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5
Q

sjogren’s

A

dry eyes & mouth. artificial tears & saliva. DMARDs

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6
Q

alpha-amylase

A

salival component. cuts up sugars, starches. neutral pH optimal.

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7
Q

lipase

A

acid pH optimum saliva component

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8
Q

4 functions of saliva

A

digestion
solubilization (taste)
lubrication
protection

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9
Q

organic materials in saliva

A

lysozyme (lyses bacteria)
lactoferrin (gobbles up free Fe)
IgA binding protein (takes IgA to the party)

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10
Q

Addison’s Na & K?

Cushing’s Na & K?

A

Na high, K low

Na low, K high

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11
Q

xerostomia

A

lack of saliva

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12
Q

what effects concentrations of ions in saliva?

A

flow rate. slower = less b/c more time to extract. KHCO3 excreted.

Isoosmotic at all rates

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13
Q

parotid saliva type

A

serous

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14
Q

submaxillary saliva type

A

serous > mucus

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15
Q

sublingual saliva type

A

mucus > serous

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16
Q

CN responsible for saliva

symp/parasymp stimulation?

A

CN VII & IX

sympathetic & parasympathetic both stimulate

17
Q

how does saliva get stim by parasympathetics?

A

chorda tympani N, parasympathetics -> Ach -> IP3

18
Q

cellular metabolism pathway to saliva?

A

cell metabolism, kallikrein, plasma protein, bradykinin, increased saliva

19
Q

sympathetic stim of salivation

A

sympathetics -> T1-T3 -> superior symp ganglion -> norepi -> cAMP increased

GI & Liver Fall 2013 CBD (16 decks)

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